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Cellosaurus OVCA429 (CVCL_3936)

[Text version]
Cell line name OVCA429
Synonyms OVCA 429; OvCA 429; OVCA-429; OVCAR-429; OVCAR 429; OVCAR429; OV429
Accession CVCL_3936
Resource Identification Initiative To cite this cell line use: OVCA429 (RRID:CVCL_3936)
Comments Part of: MD Anderson Cell Lines Project.
Doubling time: 34.58 hours (JWGray panel).
Omics: Genomics; Whole genome sequencing.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; Array-based CGH.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
Sequence variations
HLA typing Source: PubMed=26589293
Class I
HLA-AA*26:01,26:01
HLA-BB*39:01,39:01
HLA-CC*12:03,12:03
Disease Ovarian cystadenocarcinoma (NCIt: C5228)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_JY92 (OVCA429/GFP)CVCL_CZ99 (OVCA429/T40)CVCL_CZ98 (OVCA429/TxT50)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): PubMed=20596667; PubMed=22710073; PubMed=25877200; PubMed=30485824

Markers:
AmelogeninX
CSF1PO12,13 (PubMed=20596667; PubMed=22710073; PubMed=25877200)
12,13,14 (PubMed=30485824)
D2S133819,20
D3S135815,16
D5S81811,12
D7S82011,12
D8S117914,15
D13S3177,12 (PubMed=22710073; PubMed=25877200; PubMed=30485824)
12 (PubMed=20596667)
D16S53912
D18S5114
D19S43313
D21S1130
FGA24
Penta D13,14
Penta E12
TH019
TPOX9,11
vWA16,18

Run an STR similarity search on this cell line
Web pages Info; MCLP; -; https://tcpaportal.org/mclp/
Publications

PubMed=7028788; DOI=10.1172/JCI110380; PMCID=PMC370929
Robert Clinton Bast Jr., Maryellen Feeney, Herbert Lazarus, Lee Marshall Nadler, Robert B. Colvin, Robert C. Knapp;
Reactivity of a monoclonal antibody with human ovarian carcinoma.
J. Clin. Invest. 68:1331-1337(1981)

PubMed=6346879; DOI=10.1016/0002-9378(83)90999-7
Ross Stuart Berkowitz, Salim Kabawat, Herbert Lazarus, Robert B. Colvin, Robert C. Knapp, Robert Clinton Bast Jr.;
Comparison of a rabbit heteroantiserum and a murine monoclonal antibody raised against a human epithelial ovarian carcinoma cell line.
Am. J. Obstet. Gynecol. 146:607-612(1983)

PubMed=1536252; DOI=10.1016/0002-9378(92)91697-9
Andrew Berchuck, Gus Rodriguez, George Olt, Regina Whitaker, Matthew P. Boente, Bradley A. Arrick, Daniel Lyle Clarke-Pearson, Robert Clinton Bast Jr.;
Regulation of growth of normal ovarian epithelial cells and ovarian cancer cell lines by transforming growth factor-beta.
Am. J. Obstet. Gynecol. 166:676-684(1992)

PubMed=10318951; DOI=10.1073/pnas.96.10.5722; PMCID=PMC21927
Kin-Mang Lau, Samuel C. Mok, Shuk-Mei Ho;
Expression of human estrogen receptor-alpha and -beta, progesterone receptor, and androgen receptor mRNA in normal and malignant ovarian epithelial cells.
Proc. Natl. Acad. Sci. U.S.A. 96:5722-5727(1999)

PubMed=10972993; DOI=10.1002/1098-2744(200008)28:4<236::AID-MC6>3.0.CO;2-H
Christine Rauh-Adelmann, Kin-Mang Lau, Nari Sabeti, John P. Long, Samuel C. Mok, Shuk-Mei Ho;
Altered expression of BRCA1, BRCA2, and a newly identified BRCA2 exon 12 deletion variant in malignant human ovarian, prostate, and breast cancer cell lines.
Mol. Carcinog. 28:236-246(2000)

PubMed=12080474; DOI=10.1038/sj.onc.1205542
Ramon G. Manzano, Luis M. Montuenga, Mark A. Dayton, Paul Dent, Ichiro Kinoshita, Silvestre Vicent, Ginger J. Gardner, PhuongMai Nguyen, Yung-Hyun Choi, Jane B. Trepel, Nelly Auersperg, Michael J. Birrer;
CL100 expression is down-regulated in advanced epithelial ovarian cancer and its re-expression decreases its malignant potential.
Oncogene 21:4435-4447(2002)

PubMed=12960427; DOI=10.1091/mbc.E03-05-0279; PMCID=PMC266758
Marci E. Schaner, Douglas T. Ross, Giuseppe Ciaravino, Therese Sorlie, Olga G. Troyanskaya, Maximilian Diehn, Yan C. Wang, George E. Duran, Thomas L. Sikic, Sandra Caldeira, Hanne Skomedal ...Show all 26 authors... , I-Ping Tu, Tina Hernandez-Boussard, Steven W. Johnson, Peter J. O'Dwyer, Michael J. Fero, Gunnar B. Kristensen, Anne-Lise Borresen-Dale, Trevor John Hastie, Robert Tibshirani, Matt van de Rijn, Nelson N.H. Teng, Teri A. Longacre, David Botstein, Patrick O'Reilly Brown, Branimir I. Sikic; Show fewer authors
Gene expression patterns in ovarian carcinomas.
Mol. Biol. Cell 14:4376-4386(2003)

PubMed=16380993; DOI=10.1002/ijc.21671
Kuan-Chun Huang, Dong Choon Park, Shu-Kay Ng, Ji Young Lee, Xiao-Yan Ni, Wing-Chung Ng, Christina A. Bandera, William R. Welch, Ross Stuart Berkowitz, Samuel C. Mok, Shu-Wing Ng;
Selenium binding protein 1 in ovarian cancer.
Int. J. Cancer 118:2433-2440(2006)

PubMed=16382445; DOI=10.1002/gcc.20300
Yan C. Wang, Dejan Juric, Brian Francisco, Ron X. Yu, George E. Duran, G. Kevin Chen, Xin Chen, Branimir I. Sikic;
Regional activation of chromosomal arm 7q with and without gene amplification in taxane-selected human ovarian cancer cell lines.
Genes Chromosomes Cancer 45:365-374(2006)

PubMed=19926575; DOI=10.1309/AJCPTK87EMMIKPFS; PMCID=PMC3040237
Melissa S. DeRycke, John D. Andersen, Katherine M. Harrington, Stefan Eduard Pambuccian, Steve E. Kalloger, Kristin L.M. Boylan, Peter Alexander Argenta, Amy Patrice Norden Skubitz;
S100A1 expression in ovarian and endometrial endometrioid carcinomas is a prognostic indicator of relapse-free survival.
Am. J. Clin. Pathol. 132:846-856(2009)

PubMed=20204287; DOI=10.3892/or_00000728; PMCID=PMC2909445
Gregory T. Langland, Steven M. Yannone, Rachel A. Langland, Aki Nakao, Ying-Hui Guan, Sydney B.T. Long, Lien Vonguyen, David J. Chen, Joe W. Gray, Fan-Qing Chen;
Radiosensitivity profiles from a panel of ovarian cancer cell lines exhibiting genetic alterations in p53 and disparate DNA-dependent protein kinase activities.
Oncol. Rep. 23:1021-1026(2010)

PubMed=20596667; DOI=10.3892/ijo_00000688
Doo Byung Chay, Hanbyoul Cho, Beom Jin Lim, Eun Suk Kang, Youn Jin Oh, Sun Mi Choi, Bo Wook Kim, Young Tae Kim, Jae-Hoon Kim;
ER-60 (PDIA3) is highly expressed in a newly established serous ovarian cancer cell line, YDOV-139.
Int. J. Oncol. 37:399-412(2010)

PubMed=22710073; DOI=10.1016/j.ygyno.2012.06.017; PMCID=PMC3432677
Christopher T. Korch, Monique A. Spillman, Twila A. Jackson, Britta M. Jacobsen, Susan K. Murphy, Bruce Arthur Lessey, Virgil Craig Jordan, Andrew Peter Bradford;
DNA profiling analysis of endometrial and ovarian cell lines reveals misidentification, redundancy and contamination.
Gynecol. Oncol. 127:241-248(2012)

PubMed=25485619; DOI=10.1038/nbt.3080
Christiaan Klijn, Steffen Durinck, Eric W. Stawiski, Peter M. Haverty, Zhao-Shi Jiang, Han-Bin Liu, Jeremiah Degenhardt, Oleg Mayba, Florian Gnad, Jin-Feng Liu, Gregoire Pau ...Show all 30 authors... , Jens Reeder, Yi Cao, Kiran Mukhyala, Suresh K. Selvaraj, Ma-Mie Yu, Gregory J. Zynda, Matthew J. Brauer, Thomas D. Wu, Robert Clifford Gentleman, Gerard Manning, Robert L. Yauch, Richard Bourgon, David Stokoe, Zora Modrusan, Richard M. Neve, Frederic J. de Sauvage, Jeffrey Settleman, Somasekar Seshagiri, Ze-Min Zhang; Show fewer authors
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Jelle Scholtalbers, Sebastian Boegel, Thomas Bukur, Marius Byl, Sebastian Goerges, Patrick Sorn, Martin Loewer, Ugur Sahin, John C. Castle;
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076
Jun Li, Wei Zhao, Rehan Akbani, Wen-Bin Liu, Zhen-Lin Ju, Shi-Yun Ling, Christopher P. Vellano, Paul Roebuck, Qing-Hua Yu, A. Karina Eterovic, Lauren Averett Byers ...Show all 25 authors... , Michael A. Davies, Wan-Leng Deng, Y.N. Vashisht Gopal, Guo Chen, Erika Maria von Euw, Dennis Joseph Slamon, Dylan Conklin, John Victor Heymach, Adi F. Gazdar, John D. Minna, Jeffrey N. Myers, Yi-Ling Lu, Gordon B. Mills, Han Liang; Show fewer authors
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=30485824; DOI=10.1016/j.celrep.2018.10.096; PMCID=PMC6481945
Eniko Papp, Dorothy Hallberg, Gottfried E. Konecny, Daniel C. Bruhm, Vilmos Adleff, Michael Noe, Ioannis Kagiampakis, Doreen Palsgrove, Dylan Conklin, Yasuto Kinose, James R. White ...Show all 18 authors... , Michael F. Press, Ronny I. Drapkin, Hariharan Easwaran, Stephen Bruce Baylin, Dennis Joseph Slamon, Victor E. Velculescu, Robert B. Scharpf; Show fewer authors
Integrated genomic, epigenomic, and expression analyses of ovarian cancer cell lines.
Cell Rep. 25:2617-2633(2018)

Cross-references
Cell line databases/resources cancercelllines; CVCL_3936
Anatomy/cell type resources BTO; BTO_0002564
Biological sample resources BioSample; SAMN03470937
Chemistry resources PharmacoDB; OvCA429_1214_2019
Encyclopedic resources Wikidata; Q54936983
Experimental variables resources EFO; EFO_0006721
Gene expression databases ArrayExpress; E-MTAB-2706
GEO; GSM95439
GEO; GSM659391
GEO; GSM711704
GEO; GSM851929
Polymorphism and mutation databases Cosmic; 924146
Cosmic; 927567
Cosmic; 1223315
Cosmic; 1328064
Cosmic; 1434898
Cosmic; 2074245
IARC_TP53; 28487
Progenetix; CVCL_3936
Sequence databases EGA; EGAS00001000610
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number30