| Cell line name |
T24T SLT4 |
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| Synonyms |
SLT4; SL4 |
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| Accession |
CVCL_3922 |
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| Resource Identification Initiative |
To cite this cell line use: T24T SLT4 (RRID:CVCL_3922) |
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| Comments |
Part of: BLA-40 bladder carcinoma cell line panel.
Population: Caucasian; Swedish.
Characteristics: Forms metastasis in the liver of mice. Produced by passage of the parent cell line through nude mice.
Omics: Proteomics; Subcellular; Exosome.
Omics: Transcriptomics; Microarray.
Derived from site: In situ; Urinary bladder; UBERON=UBERON_0001255. |
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| Sequence variations |
- Mutation; HGNC; HGNC:5173; HRAS; Simple; p.Gly12Val (c.35G>T); ClinVar=VCV000012600; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Tyr126Ter (c.378C>G); ClinVar=VCV000578988; Zygosity=Homozygous (from parent cell line).
|
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| Disease |
Bladder carcinoma (NCIt: C4912) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_RN65 (T24T SL3) |
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| Sex of cell |
Female |
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| Age at sampling |
82Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=19147813; DOI=10.2353/ajpath.2009.080538; PMCID=PMC2630547
Steven Christopher Smith, Brian Nicholson, Matthew David Nitz, Henry Franklin Frierson Jr., Mark Smolkin, Garret M. Hampton, Wael El-Rifai, Dan Theodorescu;
Profiling bladder cancer organ site-specific metastasis identifies LAMC2 as a novel biomarker of hematogenous dissemination.
Am. J. Pathol. 174:371-379(2009) PubMed=24376083; DOI=10.1002/pmic.201300452
Dennis Kjolhede Jeppesen, Arkadiusz Nawrocki, Steffen Grann Jensen, Kasper Thorsen, Bradley Whitehead, Kenneth A. Howard, Lars Dyrskjot, Torben Falck Orntoft, Martin R. Larsen, Marie Stampe Ostenfeld;
Quantitative proteomics of fractionated membrane and lumen exosome proteins from isogenic metastatic and nonmetastatic bladder cancer cells reveal differential expression of EMT factors.
Proteomics 14:699-712(2014) PubMed=29732388; DOI=10.3233/BLC-180167; PMCID=PMC5929350
Tahlita C.M. Zuiverloon, Florus C. de Jong, James C. Costello, Dan Theodorescu;
Systematic review: characteristics and preclinical uses of bladder cancer cell lines.
Bladder Cancer 4:169-183(2018) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_3922
|
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| Anatomy/cell type resources |
BTO; BTO_0004892
|
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| Encyclopedic resources |
Wikidata; Q54971478
|
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| Gene expression databases |
GEO; GSM136257
|
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| Entry history |
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| Entry creation | 04-Apr-2012 |
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| Last entry update | 10-Apr-2025 |
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| Version number | 18 |
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