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Cellosaurus SK-MEL-37 (CVCL_3878)

[Text version]
Cell line name SK-MEL-37
Synonyms SK-Mel-37; SK-MEL37; SK-Mel 37; SK MEL 37; Sk Mel37; SKMEL-37; SK-37; SK37-MEL; BD-Mel
Accession CVCL_3878
Resource Identification Initiative To cite this cell line use: SK-MEL-37 (RRID:CVCL_3878)
Comments From: Memorial Sloan Kettering Cancer Center; New York; USA.
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
Sequence variations
Disease Amelanotic cutaneous melanoma (NCIt: C4633)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 65Y
Category Cancer cell line
STR profile Source(s): Millipore=SCC262

Markers:
AmelogeninX
CSF1PO12
D3S135816
D5S81811
D7S8209
D8S117912,15
D13S3178,11
D16S53912,14
D18S5112,16
D21S1128,30
FGA19,23
Penta D9,13
Penta E7,12
TH016,7
TPOX8,11
vWA16

Run an STR similarity search on this cell line
Publications

PubMed=978138; DOI=10.1084/jem.144.4.873; PMCID=PMC2190439
Hiroshi Shiku, Toshitada Takahashi, Herbert Friedrich Oettgen, Lloyd John Old;
Cell surface antigens of human malignant melanoma. II. Serological typing with immune adherence assays and definition of two new surface antigens.
J. Exp. Med. 144:873-881(1976)

PubMed=1067619; DOI=10.1073/pnas.73.9.3278; PMCID=PMC431008
Thomas E. Carey, Toshitada Takahashi, Lois A. Resnick-Silverman, Herbert Friedrich Oettgen, Lloyd John Old;
Cell surface antigens of human malignant melanoma: mixed hemadsorption assays for humoral immunity to cultured autologous melanoma cells.
Proc. Natl. Acad. Sci. U.S.A. 73:3278-3282(1976)

PubMed=313568; DOI=10.1073/pnas.76.6.2898; PMCID=PMC383717
Thomas E. Carey, Kenneth Oliver Lloyd, Toshitada Takahashi, Luiz Rodolpho Travassos, Lloyd John Old;
AU cell-surface antigen of human malignant melanoma: solubilization and partial characterization.
Proc. Natl. Acad. Sci. U.S.A. 76:2898-2902(1979)

PubMed=6933476; DOI=10.1073/pnas.77.7.4260; PMCID=PMC349812
Alan N. Houghton, Michael C. Taormina, Hisami Ikeda, Tadashi Watanabe, Herbert Friedrich Oettgen, Lloyd John Old;
Serological survey of normal humans for natural antibody to cell surface antigens of melanoma.
Proc. Natl. Acad. Sci. U.S.A. 77:4260-4264(1980)

DOI=10.1007/978-1-4615-7228-2_39
Alan N. Houghton, Herbert Friedrich Oettgen, Lloyd John Old;
Malignant melanoma. Current status of the search for melanoma-specific antigens.
(In book chapter) Immunodermatology. Comprehensive Immunology, Vol 7; Safai, Bijan & Good, Robert Alan (eds.); pp.557-576; Springer; Boston; USA (1981)

PubMed=7017212; DOI=10.1093/jnci/66.6.1003
Marilyn S. Pollack, Socorro D. Heagney, Philip O. Livingston, Jorgen Fogh;
HLA-A, B, C and DR alloantigen expression on forty-six cultured human tumor cell lines.
J. Natl. Cancer Inst. 66:1003-1012(1981)

PubMed=7175440; DOI=10.1084/jem.156.6.1755; PMCID=PMC2186870
Alan N. Houghton, Magdalena Eisinger, Anthony P. Albino, J. Gregory Cairncross, Lloyd John Old;
Surface antigens of melanocytes and melanomas. Markers of melanocyte differentiation and melanoma subsets.
J. Exp. Med. 156:1755-1766(1982)

PubMed=6197381; DOI=10.1002/ijc.2910320610
Michael Jules Mattes, Timothy M. Thomson, Lloyd John Old, Kenneth Oliver Lloyd;
A pigmentation-associated, differentiation antigen of human melanoma defined by a precipitating antibody in human serum.
Int. J. Cancer 32:717-721(1983)

PubMed=6864164; DOI=10.1084/jem.158.1.53; PMCID=PMC2187084
Alan N. Houghton, Hannah Brooks, Richard J. Cote, Michael C. Taormina, Herbert Friedrich Oettgen, Lloyd John Old;
Detection of cell surface and intracellular antigens by human monoclonal antibodies. Hybrid cell lines derived from lymphocytes of patients with malignant melanoma.
J. Exp. Med. 158:53-65(1983)

PubMed=6582512; DOI=10.1073/pnas.81.2.568; PMCID=PMC344720
Michael Jules Mattes, Carlos Cordon-Cardo, John L. Lewis Jr., Lloyd John Old, Kenneth Oliver Lloyd;
Cell surface antigens of human ovarian and endometrial carcinoma defined by mouse monoclonal antibodies.
Proc. Natl. Acad. Sci. U.S.A. 81:568-572(1984)

PubMed=2983346; DOI=10.1073/pnas.82.5.1470; PMCID=PMC397284
Nicholas C. Dracopoli, Alan N. Houghton, Lloyd John Old;
Loss of polymorphic restriction fragments in malignant melanoma: implications for tumor heterogeneity.
Proc. Natl. Acad. Sci. U.S.A. 82:1470-1474(1985)

PubMed=3081645; DOI=10.4049/jimmunol.136.7.2534
Mounanandham Panneerselvam, Sydney Welt, Lloyd John Old, Carl-Wilhelm Vogel;
A molecular mechanism of complement resistance of human melanoma cells.
J. Immunol. 136:2534-2541(1986)

PubMed=3518877; DOI=10.3109/07357908609038260
Jorgen Fogh;
Human tumor lines for cancer research.
Cancer Invest. 4:157-184(1986)

PubMed=2784858; DOI=10.1073/pnas.86.8.2804; PMCID=PMC287007
Alexander Knuth, Thomas Wolfel, Eva Klehmann-Hieb, Thierry Boon, Karl-Hermann Meyer zum Buschenfelde;
Cytolytic T-cell clones against an autologous human melanoma: specificity study and definition of three antigens by immunoselection.
Proc. Natl. Acad. Sci. U.S.A. 86:2804-2808(1989)

PubMed=1778766; DOI=10.1111/j.1349-7006.1991.tb01816.x; PMCID=PMC5918361
Eisuke Takeshima, Michinari Hamaguchi, Tadashi Watanabe, Seiji Akiyama, Masato Kataoka, Yukano Ohnishi, Heng-Yi Xiao, Yoshiyuki Nagai, Hiroshi Takagi;
Aberrant elevation of tyrosine-specific phosphorylation in human gastric cancer cells.
Jpn. J. Cancer Res. 82:1428-1435(1991)

PubMed=9598804; DOI=10.1002/(SICI)1098-2264(199806)22:2<157::AID-GCC11>3.0.CO;2-N
Graeme J. Walker, Jose F. Flores, J. Michael Glendening, Amy Hsiu-Ti Lin, Isabel D.C. Markl, Jane W. Fountain;
Virtually 100% of melanoma cell lines harbor alterations at the DNA level within CDKN2A, CDKN2B, or one of their downstream targets.
Genes Chromosomes Cancer 22:157-163(1998)

PubMed=9692547; DOI=10.1038/sj.onc.1201881
Hensin Tsao, Xue Zhang, Eric Benoit, Frank G. Haluska;
Identification of PTEN/MMAC1 alterations in uncultured melanomas and melanoma cell lines.
Oncogene 16:3397-3402(1998)

PubMed=10766161
Hensin Tsao, Xue Zhang, Kianna Fowlkes, Frank G. Haluska;
Relative reciprocity of NRAS and PTEN/MMAC1 alterations in cutaneous melanoma cell lines.
Cancer Res. 60:1800-1804(2000)

PubMed=15009714; DOI=10.1046/j.0022-202X.2004.22243.x; PMCID=PMC2586668
Hensin Tsao, Vikas Goel, Heng Wu, Guang Yang, Frank G. Haluska;
Genetic interaction between NRAS and BRAF mutations and PTEN/MMAC1 inactivation in melanoma.
J. Invest. Dermatol. 122:337-341(2004)

PubMed=21725359; DOI=10.1038/onc.2011.250; PMCID=PMC3267014
Feng Xing, Yogindra Persaud, Christine A. Pratilas, Barry Stephen Taylor, Manickam Janakiraman, Qing-Bai She, Humilidad F. Gallardo, C. Liu, Taha Merghoub, Blake E. Hefter, Igor Dolgalev ...Show all 19 authors... , Agnes J. Viale, Adriana Heguy, Elisa de Stanchina, David Cobrinik, Gideon Bollag, Jedd D. Wolchok, Alan N. Houghton, David B. Solit; Show fewer authors
Concurrent loss of the PTEN and RB1 tumor suppressors attenuates RAF dependence in melanomas harboring (V600E)BRAF.
Oncogene 31:446-457(2012)

PubMed=24576830; DOI=10.1158/0008-5472.CAN-13-2625; PMCID=PMC4005042
Moriah Heller Nissan, Christine A. Pratilas, Alexis M. Jones, Ricardo Ramirez, Helen Won, Cai-Lian Liu, Shakuntala Tiwari, Li Kong, Aphrothiti J. Hanrahan, Zhan Yao, Taha Merghoub ...Show all 19 authors... , Antoni Ribas, Paul B. Chapman, Rona D. Yaeger, Barry Stephen Taylor, Nikolaus Schultz, Michael F. Berger, Neal Rosen, David B. Solit; Show fewer authors
Loss of NF1 in cutaneous melanoma is associated with RAS activation and MEK dependence.
Cancer Res. 74:2340-2350(2014)

Cross-references
Cell line collections (Providers) Millipore; SCC262
Cell line databases/resources cancercelllines; CVCL_3878
Anatomy/cell type resources BTO; BTO_0002967
Encyclopedic resources Wikidata; Q54954130
Experimental variables resources EFO; EFO_0022424
Polymorphism and mutation databases Cosmic; 706102
Cosmic; 721826
Cosmic; 851046
Cosmic; 888842
Cosmic; 933137
Cosmic; 1303056
Cosmic; 1669151
Entry history
Entry creation04-Apr-2012
Last entry update19-Dec-2024
Version number32