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Cellosaurus HHUA (CVCL_3866)

[Text version]
Cell line name HHUA
Synonyms HHUA-1
Accession CVCL_3866
Resource Identification Initiative To cite this cell line use: HHUA (RRID:CVCL_3866)
Comments Problematic cell line: Possibly contaminated. HHUA (distributed by RCB) and SNG-M (distributed by JCRB) share similar STR profiles and have been established by the same research group. While HHUA was described in 1984 and SNG-M in 1977 it has not been possible to establish which of the two cell lines are derived from each other. Thus it has been decided to consider them as being sister cell lines originating from the same donor.
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00628.
Population: Japanese.
Doubling time: 34 hours (Note=At 5th passage), 30 hours (Note=At 15th passage) (PubMed=6706228); 30 hours (PubMed=6532401); 28 hours (PubMed=10457904).
Derived from site: In situ; Endometrium; UBERON=UBERON_0001295.
Sequence variations
Disease Endometrial adenocarcinoma (NCIt: C7359)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_1707 ! SNG-M
CVCL_S914 ! SNG-P
Sex of cell Female
Age at sampling 52-54Y
Category Cancer cell line
STR profile Source(s): DepMap=ACH-002026; RCB=RCB0658

Markers:
AmelogeninX
CSF1PO11,12
D3S135814,15
D5S8189,12,13,14 (DepMap=ACH-002026)
9,13,14 (RCB=RCB0658)
D7S82010,13 (RCB=RCB0658)
10,13,14 (DepMap=ACH-002026)
D8S117911,13
D13S3178,11
D16S53910,12
D18S5112,18,19
D21S1129,30
FGA21,22
Penta D8,11
Penta E11,13
TH016,7
TPOX8,9
vWA17,18,19 (RCB=RCB0658)
17,19,20,21 (DepMap=ACH-002026)

Run an STR similarity search on this cell line
Web pages Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Info; RCB; -; https://cell.brc.riken.jp/en/wp-content/uploads/pdf/announcement/RCB0658_en.pdf
Publications

PubMed=6532401; DOI=10.1111/j.1447-0756.1984.tb00721.x
Ishiwata I., Ishiwata C., Ishikawa H.
Effects of estradiol-17 beta and progesterone on cell proliferation and differentiation of the human endometrial carcinoma cell line (HHUA) in vitro.
Asia Oceania J. Obstet. Gynaecol. 10:531-538(1984)

PubMed=6706228; DOI=10.1016/0090-8258(84)90212-9
Ishiwata I., Ishiwata C., Soma M., Arai J., Ishikawa H.
Establishment of human endometrial adenocarcinoma cell line containing estradiol-17 beta and progesterone receptors.
Gynecol. Oncol. 17:281-290(1984)

PubMed=2429643; DOI=10.1111/j.1447-0756.1986.tb00192.x
Ishiwata I., Ishiwata C., Nozawa S., Ishikawa H.
CA125 production by gynecologic tumors in vitro and its modulation induced by dibutyl cyclic adenosine monophosphate.
Asia Oceania J. Obstet. Gynaecol. 12:285-290(1986)

PubMed=2448191; DOI=10.1016/0090-8258(88)90151-5
Ishiwata I., Ishiwata C., Soma M., Ono I., Nakaguchi T., Ishikawa H.
Tumor angiogenic activity of gynecologic tumor cell lines on the chorioallantoic membrane.
Gynecol. Oncol. 29:87-93(1988)

PubMed=8105795; DOI=10.1002/mc.2940080303
Enomoto T., Fujita M., Inoue M., Nakazawa-Miyamoto A., Tanizawa O., Nomura T.
Alterations of the Rb gene and its association with Ki-ras activation and p53 inactivation in endometrial adenocarcinoma.
Mol. Carcinog. 8:132-137(1993)

PubMed=9436037
Soma M., Ishiwata I., Ishiwata C., Nakaguchi T., Ono I., Kiguchi K., Hashimoto H., Tachibana T., Ishikawa H., Nozawa S.
Tissue reconstruction of gynecologic tumor cells in the rotation culture system.
Hum. Cell 10:175-181(1997)

PubMed=9573483
Ishiwata I., Tokieda Y., Ishiwata C., Okane N., Iguchi M., Sato K., Ishikawa H.
Effects of feeder cells (human cancer cell lines) on the development of mouse embryos by co-culture.
Hum. Cell 10:237-246(1997)

PubMed=10457904
Ishiwata I., Sudo T., Kiguchi K., Ishikawa H.
Tumor angiogenesis factors produced by cancer cells.
Hum. Cell 12:37-46(1999)

PubMed=15901131; DOI=10.1016/j.prp.2005.01.002
Murai Y., Hayashi S., Takahashi H., Tsuneyama K., Takano Y.
Correlation between DNA alterations and p53 and p16 protein expression in cancer cell lines.
Pathol. Res. Pract. 201:109-115(2005)

Cross-references
Cell line collections (Providers) RCB; RCB0658
Cell line databases/resources CLO; CLO_0050885
cancercelllines; CVCL_3866
DepMap; ACH-002026
TOKU-E; 4122
Biological sample resources BioSample; SAMN03472264
Encyclopedic resources Wikidata; Q54887500
Polymorphism and mutation databases Cosmic; 713497
Cosmic; 735333
Cosmic; 1177619
Cosmic; 1223488
Cosmic; 1241346
Cosmic; 1622898
Cosmic; 1696758
Cosmic; 2030474
IARC_TP53; 2377
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number27