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Cellosaurus HHUA (CVCL_3866)

[Text version]
Cell line name HHUA
Synonyms HHUA-1
Accession CVCL_3866
Resource Identification Initiative To cite this cell line use: HHUA (RRID:CVCL_3866)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Population: Japanese.
Doubling time: 34 hours (at 5th passage), 30 hours (at 15th passage) (PubMed=6706228); 30 hours (PubMed=6532401); 28 hours (PubMed=10457904).
Derived from sampling site: Endometrium.
Sequence variations
  • Mutation; HGNC; 11998; TP53; Simple; p.Ala138Val (c.413C>T); ClinVar=VCV000184863; Zygosity=Unspecified (PubMed=8105795).
Disease Endometrial adenocarcinoma (NCIt: C7359)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 54Y
Category Cancer cell line
STR profile Source(s): DepMap; RCB

D5S8189,12,13,14 (DepMap)
9,13,14 (RCB)
D7S82010,13 (RCB)
10,13,14 (DepMap)
Penta D8,11
Penta E11,13
vWA17,18,19 (RCB)
17,19,20,21 (DepMap)

Run an STR similarity search on this cell line

PubMed=6532401; DOI=10.1111/j.1447-0756.1984.tb00721.x
Ishiwata I., Ishiwata C., Ishikawa H.
Effects of estradiol-17 beta and progesterone on cell proliferation and differentiation of the human endometrial carcinoma cell line (HHUA) in vitro.
Asia Oceania J. Obstet. Gynaecol. 10:531-538(1984)

PubMed=6706228; DOI=10.1016/0090-8258(84)90212-9
Ishiwata I., Ishiwata C., Soma M., Arai J., Ishikawa H.
Establishment of human endometrial adenocarcinoma cell line containing estradiol-17 beta and progesterone receptors.
Gynecol. Oncol. 17:281-290(1984)

PubMed=2429643; DOI=10.1111/j.1447-0756.1986.tb00192.x
Ishiwata I., Ishiwata C., Nozawa S., Ishikawa H.
CA125 production by gynecologic tumors in vitro and its modulation induced by dibutyl cyclic adenosine monophosphate.
Asia Oceania J. Obstet. Gynaecol. 12:285-290(1986)

PubMed=2448191; DOI=10.1016/0090-8258(88)90151-5
Ishiwata I., Ishiwata C., Soma M., Ono I., Nakaguchi T., Ishikawa H.
Tumor angiogenic activity of gynecologic tumor cell lines on the chorioallantoic membrane.
Gynecol. Oncol. 29:87-93(1988)

PubMed=8105795; DOI=10.1002/mc.2940080303
Enomoto T., Fujita M., Inoue M., Nakazawa-Miyamoto A., Tanizawa O., Nomura T.
Alterations of the Rb gene and its association with Ki-ras activation and p53 inactivation in endometrial adenocarcinoma.
Mol. Carcinog. 8:132-137(1993)

Soma M., Ishiwata I., Ishiwata C., Nakaguchi T., Ono I., Kiguchi K., Hashimoto H., Tachibana T., Ishikawa H., Nozawa S.
Tissue reconstruction of gynecologic tumor cells in the rotation culture system.
Hum. Cell 10:175-181(1997)

Ishiwata I., Tokieda Y., Ishiwata C., Okane N., Iguchi M., Sato K., Ishikawa H.
Effects of feeder cells (human cancer cell lines) on the development of mouse embryos by co-culture.
Hum. Cell 10:237-246(1997)

Ishiwata I., Sudo T., Kiguchi K., Ishikawa H.
Tumor angiogenesis factors produced by cancer cells.
Hum. Cell 12:37-46(1999)

PubMed=15901131; DOI=10.1016/j.prp.2005.01.002
Murai Y., Hayashi S., Takahashi H., Tsuneyama K., Takano Y.
Correlation between DNA alterations and p53 and p16 protein expression in cancer cell lines.
Pathol. Res. Pract. 201:109-115(2005)

Cell line collections RCB; RCB0658
Cell line databases/resources CLO; CLO_0050885
DepMap; ACH-002026
TOKU-E; 4122
Biological sample resources BioSample; SAMN03472264
Encyclopedic resources Wikidata; Q54887500
Polymorphism and mutation databases Cosmic; 713497
Cosmic; 735333
Cosmic; 1177619
Cosmic; 1223488
Cosmic; 1241346
Cosmic; 1622898
Cosmic; 1696758
Cosmic; 2030474
IARC_TP53; 2377
Entry history
Entry creation04-Apr-2012
Last entry update23-Jun-2022
Version number21