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Cellosaurus K562/Adr (CVCL_3827)

[Text version]
Cell line name K562/Adr
Synonyms K562/adr; K-562adr; K562adr; K562/ADM
Accession CVCL_3827
Secondary accession CVCL_2808
Resource Identification Initiative To cite this cell line use: K562/Adr (RRID:CVCL_3827)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_28748; Doxorubicin (Adriablastin; Adriamycin).
Omics: Variations; SNP array analysis.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 14 fused to ABL1 exon 2 (b3a2 transcript) (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gln136fs*13 (c.406_407insC); Zygosity=Homozygous (from parent cell line).
Disease Blast phase chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C9110)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0004 (K-562)
Sex of cell Female
Age at sampling 53Y
Category Cancer cell line
STR profile Source(s): JCRB=JCRB1002; RCB=RCB1898; TKG=TKG 0211

Markers:
AmelogeninX
CSF1PO9,10
D5S81811,12
D7S8209,11
D13S3178
D16S53911,12
TH019.3
TPOX8,9
vWA16

Run an STR similarity search on this cell line
Publications

PubMed=3091555; DOI=10.20772/cancersci1985.77.7_682
Takashi Tsuruo, Harumi Iida-Saito, Hironori Kawabata, Tomoko Oh-hara, Hirofumi Hamada, Tadashi Utakoji;
Characteristics of resistance to adriamycin in human myelogenous leukemia K562 resistant to adriamycin and in isolated clones.
Jpn. J. Cancer Res. 77:682-692(1986)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

Cross-references
Cell line collections (Providers) JCRB; JCRB1002
JCRB; NIHS0053 - Discontinued
RCB; RCB1898
TKG; TKG 0211
Cell line databases/resources CLO; CLO_0009840
CLO; CLO_0050121
cancercelllines; CVCL_3827
LINCS_LDP; LCL-1104
Anatomy/cell type resources BTO; BTO_0002554
Chemistry resources ChEMBL-Cells; CHEMBL3833721
ChEMBL-Targets; CHEMBL4296449
PubChem_Cell_line; CVCL_3827
Encyclopedic resources Wikidata; Q54899403
Gene expression databases GEO; GSM827221
Polymorphism and mutation databases Progenetix; CVCL_3827
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number29