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Cellosaurus OVCA432 (CVCL_3769)

[Text version]
Cell line name OVCA432
Synonyms OV-CA 432; OVCA 432; OvCA 432; OVCA-432; OVCA432_Bast; OVCAR-432; OVCAR 432; OVCAR432
Accession CVCL_3769
Resource Identification Initiative To cite this cell line use: OVCA432 (RRID:CVCL_3769)
Comments Doubling time: 37.09 hours (JWGray panel).
Omics: Phenotyping; Drug screening.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; Array-based CGH.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
Sequence variations
HLA typing Source: PubMed=26589293
Class I
HLA-AA*01:01,29:02
HLA-BB*44:03,55:01
HLA-CC*03:03,16:01
Class II
HLA-DQDQB1*02:02,03:02
HLA-DRDRB1*07:01,11:79
Disease Ovarian serous adenocarcinoma (NCIt: C7550)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_IQ28 ! LAZ-446
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): PubMed=22710073; PubMed=25877200

Markers:
AmelogeninX
CSF1PO10,11
D2S133820,24
D3S135816
D5S81812,13
D7S8208,10
D8S117910,14
D13S31711,12
D16S53912
D18S5115,16
D19S43312,15
D21S1129,31.2
FGA20,24
Penta D10,14
Penta E13,19
TH0110
TPOX11
vWA15,19

Run an STR similarity search on this cell line
Publications

PubMed=7028788; DOI=10.1172/JCI110380; PMCID=PMC370929
Robert Clinton Bast Jr., Maryellen Feeney, Herbert Lazarus, Lee Marshall Nadler, Robert B. Colvin, Robert C. Knapp;
Reactivity of a monoclonal antibody with human ovarian carcinoma.
J. Clin. Invest. 68:1331-1337(1981)

PubMed=6346879; DOI=10.1016/0002-9378(83)90999-7
Ross Stuart Berkowitz, Salim Kabawat, Herbert Lazarus, Robert B. Colvin, Robert C. Knapp, Robert Clinton Bast Jr.;
Comparison of a rabbit heteroantiserum and a murine monoclonal antibody raised against a human epithelial ovarian carcinoma cell line.
Am. J. Obstet. Gynecol. 146:607-612(1983)

PubMed=1536252; DOI=10.1016/0002-9378(92)91697-9
Andrew Berchuck, Gus Rodriguez, George Olt, Regina Whitaker, Matthew P. Boente, Bradley A. Arrick, Daniel Lyle Clarke-Pearson, Robert Clinton Bast Jr.;
Regulation of growth of normal ovarian epithelial cells and ovarian cancer cell lines by transforming growth factor-beta.
Am. J. Obstet. Gynecol. 166:676-684(1992)

PubMed=7836420; DOI=10.1074/jbc.270.3.999
Timothy N. Young, Salvatore Vincent Pizzo, Mary Sharon Stack;
A plasma membrane-associated component of ovarian adenocarcinoma cells enhances the catalytic efficiency of matrix metalloproteinase-2.
J. Biol. Chem. 270:999-1002(1995)

PubMed=10318951; DOI=10.1073/pnas.96.10.5722; PMCID=PMC21927
Kin-Mang Lau, Samuel C. Mok, Shuk-Mei Ho;
Expression of human estrogen receptor-alpha and -beta, progesterone receptor, and androgen receptor mRNA in normal and malignant ovarian epithelial cells.
Proc. Natl. Acad. Sci. U.S.A. 96:5722-5727(1999)

PubMed=10972993; DOI=10.1002/1098-2744(200008)28:4<236::AID-MC6>3.0.CO;2-H
Christine Rauh-Adelmann, Kin-Mang Lau, Nari Sabeti, John P. Long, Samuel C. Mok, Shuk-Mei Ho;
Altered expression of BRCA1, BRCA2, and a newly identified BRCA2 exon 12 deletion variant in malignant human ovarian, prostate, and breast cancer cell lines.
Mol. Carcinog. 28:236-246(2000)

PubMed=11793438; DOI=10.1002/gcc.1221
Pulivarthi H. Rao, Charles P. Harris, Xin-Yan Lu, Xiao-Nan Li, Samuel C. Mok, Ching C. Lau;
Multicolor spectral karyotyping of serous ovarian adenocarcinoma.
Genes Chromosomes Cancer 33:123-132(2002)

PubMed=12960427; DOI=10.1091/mbc.E03-05-0279; PMCID=PMC266758
Marci E. Schaner, Douglas T. Ross, Giuseppe Ciaravino, Therese Sorlie, Olga G. Troyanskaya, Maximilian Diehn, Yan C. Wang, George E. Duran, Thomas L. Sikic, Sandra Caldeira, Hanne Skomedal ...Show all 26 authors... , I-Ping Tu, Tina Hernandez-Boussard, Steven W. Johnson, Peter J. O'Dwyer, Michael J. Fero, Gunnar B. Kristensen, Anne-Lise Borresen-Dale, Trevor John Hastie, Robert Tibshirani, Matt van de Rijn, Nelson N.H. Teng, Teri A. Longacre, David Botstein, Patrick O'Reilly Brown, Branimir I. Sikic; Show fewer authors
Gene expression patterns in ovarian carcinomas.
Mol. Biol. Cell 14:4376-4386(2003)

PubMed=20204287; DOI=10.3892/or_00000728; PMCID=PMC2909445
Gregory T. Langland, Steven M. Yannone, Rachel A. Langland, Aki Nakao, Ying-Hui Guan, Sydney B.T. Long, Lien Vonguyen, David J. Chen, Joe W. Gray, Fan-Qing Chen;
Radiosensitivity profiles from a panel of ovarian cancer cell lines exhibiting genetic alterations in p53 and disparate DNA-dependent protein kinase activities.
Oncol. Rep. 23:1021-1026(2010)

PubMed=22585861; DOI=10.1158/2159-8290.CD-11-0224; PMCID=PMC5057396
Richard Marcotte, Kevin R. Brown, Fernando Jose Suarez Saiz, Azin Sayad, Konstantina Karamboulas, Paul M. Krzyzanowski, Fabrice Sircoulomb, Mauricio Medrano, Yaroslav Fedyshyn, Judice Lie-Yong Koh, Dewald van Dyk ...Show all 28 authors... , Bohdana Fedyshyn, Marianna Luhova, Glauber C. Brito, Franco J. Vizeacoumar, Frederick S. Vizeacoumar, Alessandro Datti, Dahlia Kasimer, Alla Buzina, Patricia Mero, Christine Misquitta, Josee Normand, Maliha Haider, Troy Ketela, Jeffrey L. Wrana, Robert Rottapel, Benjamin G. Neel, Jason Moffat; Show fewer authors
Essential gene profiles in breast, pancreatic, and ovarian cancer cells.
Cancer Discov. 2:172-189(2012)

PubMed=22710073; DOI=10.1016/j.ygyno.2012.06.017; PMCID=PMC3432677
Christopher T. Korch, Monique A. Spillman, Twila A. Jackson, Britta M. Jacobsen, Susan K. Murphy, Bruce Arthur Lessey, Virgil Craig Jordan, Andrew Peter Bradford;
DNA profiling analysis of endometrial and ovarian cell lines reveals misidentification, redundancy and contamination.
Gynecol. Oncol. 127:241-248(2012)

PubMed=23415752; DOI=10.1016/j.molonc.2012.12.007; PMCID=PMC4106023
Britta Stordal, Kirsten Timms, Angela Farrelly, Danielle Gallagher, Steven Busschots, Mickael Renaud, Julien Thery, Deborah Williams, Jennifer Potter, Thanh Tran, Greg Korpanty ...Show all 19 authors... , Mattia Cremona, Mark S. Carey, Jie Li, Yang Li, Ozlem Aslan, John J. O'Leary, Gordon B. Mills, Bryan T. Hennessy; Show fewer authors
BRCA1/2 mutation analysis in 41 ovarian cell lines reveals only one functionally deleterious BRCA1 mutation.
Mol. Oncol. 7:567-579(2013)

PubMed=25485619; DOI=10.1038/nbt.3080
Christiaan Klijn, Steffen Durinck, Eric W. Stawiski, Peter M. Haverty, Zhao-Shi Jiang, Han-Bin Liu, Jeremiah Degenhardt, Oleg Mayba, Florian Gnad, Jin-Feng Liu, Gregoire Pau ...Show all 30 authors... , Jens Reeder, Yi Cao, Kiran Mukhyala, Suresh K. Selvaraj, Ma-Mie Yu, Gregory J. Zynda, Matthew J. Brauer, Thomas D. Wu, Robert Clifford Gentleman, Gerard Manning, Robert L. Yauch, Richard Bourgon, David Stokoe, Zora Modrusan, Richard M. Neve, Frederic J. de Sauvage, Jeffrey Settleman, Somasekar Seshagiri, Ze-Min Zhang; Show fewer authors
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Jelle Scholtalbers, Sebastian Boegel, Thomas Bukur, Marius Byl, Sebastian Goerges, Patrick Sorn, Martin Loewer, Ugur Sahin, John C. Castle;
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=28273451; DOI=10.1016/j.celrep.2017.02.028
Mauricio Medrano, Laudine Communal, Kevin R. Brown, Marcin Iwanicki, Josee Normand, Joshua Paterson, Fabrice Sircoulomb, Paul M. Krzyzanowski, Marian Novak, Sasha A. Doodnauth, Fernando Jose Suarez Saiz ...Show all 19 authors... , Jane Cullis, Rima Al-awar, Benjamin G. Neel, John McPherson, Ronny I. Drapkin, Laurie Ailles, Anne-Marie Mes-Masson, Robert Rottapel; Show fewer authors
Interrogation of functional cell-surface markers identifies CD151 dependency in high-grade serous ovarian cancer.
Cell Rep. 18:2343-2358(2017)

Cross-references
Cell line databases/resources CLO; CLO_0008278
CLDB; cl3778
cancercelllines; CVCL_3769
Anatomy/cell type resources BTO; BTO_0002565
Biological sample resources BioSample; SAMN03470830
Chemistry resources GDSC; 1480366
PharmacoDB; OvCA432_1215_2019
Encyclopedic resources Wikidata; Q54936988
Experimental variables resources EFO; EFO_0006722
Gene expression databases ArrayExpress; E-MTAB-2706
GEO; GSM659392
GEO; GSM711705
GEO; GSM851930
GEO; GSM2474991
Polymorphism and mutation databases Cosmic; 924147
Cosmic; 991322
Cosmic; 1524354
IARC_TP53; 28488
Sequence databases EGA; EGAS00001000610
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number30