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Cellosaurus MLE-12 (CVCL_3751)

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Cell line name MLE-12
Synonyms MLE 12; MLE12; Murine Lung Epithelial-12
Accession CVCL_3751
Resource Identification Initiative To cite this cell line use: MLE-12 (RRID:CVCL_3751)
Comments Doubling time: 7-9 hours (Note=At 12th passage) (PubMed=8248207).
Genetic integration: Method=Transgenic mouse; Gene=UniProtKB; P03070; Simian virus 40 (SV40) large T antigen.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Cell type: Epithelial cell; CL=CL_0000066.
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: FVB/N-Tg(SFTPC-TAg)5.1Jaw transgenic.
Hierarchy Children:
CVCL_F1RZ (HyCyte MLE-12 KO-mFmr1)CVCL_F1S0 (HyCyte MLE-12 KO-mMfsd2a)CVCL_F1S1 (HyCyte MLE-12 KO-mSnx10)
CVCL_F1S2 (HyCyte MLE-12 KO-mZbp1)
Sex of cell Female
Age at sampling 5M
Category Transformed cell line
Publications

PubMed=8248207; DOI=10.1073/pnas.90.23.11029; PMCID=PMC47915
Kathryn A. Wikenheiser-Brokamp, Diane Kohmescher Vorbroker, Ward R. Rice, Jean C. Clark, Cindy J. Bachurski, Herbert Kazuto Oie, Jeffrey A. Whitsett;
Production of immortalized distal respiratory epithelial cell lines from surfactant protein C/simian virus 40 large tumor antigen transgenic mice.
Proc. Natl. Acad. Sci. U.S.A. 90:11029-11033(1993)

Cross-references
Cell line collections (Providers) ATCC; CRL-2110
CLS; 305314
Cell line databases/resources CLO; CLO_0007746
Anatomy/cell type resources BTO; BTO_0002268
Encyclopedic resources Wikidata; Q54905967
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number18