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Cellosaurus MeT-5A (CVCL_3749)

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Cell line name MeT-5A
Synonyms MeT 5A; MeT5A; Met5A; MET5A; Mesothelial cells transfected with pRSV-T 5A
Accession CVCL_3749
Resource Identification Initiative To cite this cell line use: MeT-5A (RRID:CVCL_3749)
Comments Group: Patented cell line.
Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-9444.
Genetic integration: Method=Transfection; Gene=UniProtKB; P03070; Simian virus 40 (SV40) large T antigen.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) (Note=pRSV-T).
Omics: Transcriptomics; Microarray.
Derived from site: In situ; Lung, pleura; UBERON=UBERON_0000977.
Cell type: Mesothelial cell; CL=CL_0000077.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_LJ67 (MeT-5A/EJ-ras)
Sex of cell Male
Age at sampling Adult
Category Transformed cell line
STR profile Source(s): ATCC=CRL-9444; IZSLER=BS CL 214

Markers:
AmelogeninX,Y
CSF1PO10,12
D2S133818,19
D3S135817,18
D5S81812
D7S82010
D8S117912,13
D13S31711,13
D16S53912
D18S5115,23
D19S43315
D21S1131.2
FGA22,23
Penta D10,11
Penta E10,16
TH016,9.3
TPOX8 (ATCC=CRL-9444)
8,11 (IZSLER=BS CL 214)
vWA15,18

Run an STR similarity search on this cell line
Web pages Info; Wikipedia; -; https://en.wikipedia.org/wiki/MeT-5a
Publications

Patent=US4885238
Roger Robert Reddel, Ke Yang, Johng Sik Rhim, Douglas E. Brash, Robert T. Su, John F. Lechner, Brenda Isen Gerwin, Curtis Craig Harris, Paul A. Amstad;
Immortalized human bronchial epithelial mesothelial cell lines.
Patent number US4885238, 05-Dec-1989

PubMed=2541616; PMCID=PMC1879894
Yang Ke, Roger Robert Reddel, Brenda Isen Gerwin, Helen K. Reddel, Angela N.A. Somers, Mary G. McMenamin, Moira A. LaVeck, Rolf A. Stahel, John F. Lechner, Curtis Craig Harris;
Establishment of a human in vitro mesothelial cell model system for investigating mechanisms of asbestos-induced mesothelioma.
Am. J. Pathol. 134:979-991(1989)

PubMed=9533946; DOI=10.1165/ajrcmb.18.4.2943
Katriina Kahlos, Sisko Anttila, Tiina M. Asikainen, Kristiina Kinnula, Kari O. Raivio, Karin Mattson, Kaija Linnainmaa, Vuokko Liisa Kinnula;
Manganese superoxide dismutase in healthy human pleural mesothelium and in malignant pleural mesothelioma.
Am. J. Respir. Cell Mol. Biol. 18:570-580(1998)

PubMed=15920167; DOI=10.1016/S0002-9440(10)62492-3; PMCID=PMC1363736
Gavin J. Gordon, Graham N. Rockwell, Roderick V. Jensen, James George Rheinwald, Jonathan Neil Glickman, Joshua Paul Aronson, Brian J. Pottorf, Matthew David Nitz, William G. Richards, David John Sugarbaker, Raphael Bueno;
Identification of novel candidate oncogenes and tumor suppressors in malignant pleural mesothelioma using large-scale transcriptional profiling.
Am. J. Pathol. 166:1827-1840(2005)

PubMed=17331233; DOI=10.1186/1471-2164-8-62; PMCID=PMC1821332
Penny Nymark, Pamela M. Lindholm, Mikko V. Korpela, Leo Lahti, Salla Ruosaari, Samuel Kaski, Jaakko Hollmen, Sisko Anttila, Vuokko Liisa Kinnula, Sakari Knuutila;
Gene expression profiles in asbestos-exposed epithelial and mesothelial lung cell lines.
BMC Genomics 8:62.1-62.14(2007)

PubMed=21356356; DOI=10.1016/j.ajpath.2010.12.014; PMCID=PMC3070574
Fabien Gueugnon, Sabrina Leclercq, Christophe Blanquart, Christine Sagan, Laurent Cellerin, Martine Padieu, Christian Perigaud, Arnaud Scherpereel, Marc Gregoire;
Identification of novel markers for the diagnosis of malignant pleural mesothelioma.
Am. J. Pathol. 178:1033-1042(2011)

PubMed=21454801; DOI=10.1165/rcmb.2010-0282OC; PMCID=PMC3262687
Arti Shukla, Trisha F. Barrett, Maximilian B. MacPherson, Jedd Michael Hillegass, Naomi Kay Fukagawa, William A. Swain, Kenneth J. O'Byrne, Joseph R. Testa, Harvey I. Pass, Stephen P. Faux, Brooke Taylor Mossman;
An extracellular signal-regulated kinase 2 survival pathway mediates resistance of human mesothelioma cells to asbestos-induced injury.
Am. J. Respir. Cell Mol. Biol. 45:906-914(2011)

PubMed=22576795; DOI=10.3892/or.2012.1763
Hironori Ashinuma, Yuichi Takiguchi, Satoru Kitazono, Miyako Kitazono-Saitoh, Atsushi Kitamura, Tetsuhiro Chiba, Yuji Tada, Katsushi Kurosu, Emiko Sakaida, Ikuo Sekine, Nobuhiro Tanabe ...Show all 14 authors... , Atsushi Iwama, Osamu Yokosuka, Koichiro Tatsumi; Show fewer authors
Antiproliferative action of metformin in human lung cancer cell lines.
Oncol. Rep. 28:8-14(2012)

PubMed=24926545; DOI=10.1097/JTO.0000000000000202; PMCID=PMC4287384
Erick Riquelme, Milind Bhalchandra Suraokar, Jaime Rodriguez, Barbara Mino, Heather Y. Lin, David C. Rice, Anne Tsao, Ignacio Ivan Wistuba;
Frequent coamplification and cooperation between C-MYC and PVT1 oncogenes promote malignant pleural mesothelioma.
J. Thorac. Oncol. 9:998-1007(2014)

PubMed=26011428; DOI=10.1111/cas.12698; PMCID=PMC4556387
Shuhei Hakiri, Hirotaka Osada, Futoshi Ishiguro, Hideki Murakami, Yuko Murakami-Tonami, Kohei Yokoi, Yoshitaka Sekido;
Functional differences between wild-type and mutant-type BRCA1-associated protein 1 tumor suppressor against malignant mesothelioma cells.
Cancer Sci. 106:990-999(2015)

PubMed=28553954; DOI=10.1038/onc.2017.147
T. Kato, Tatsuhiro Sato, Kohei Yokoi, Yoshitaka Sekido;
E-cadherin expression is correlated with focal adhesion kinase inhibitor resistance in merlin-negative malignant mesothelioma cells.
Oncogene 36:5522-5531(2017)

PubMed=33567673; DOI=10.3390/cancers13040685; PMCID=PMC7915464
Maureen Keller, Katarina Reis, Anders Hjerpe, Katalin Dobra, Pontus Aspenstrom;
Cytoskeletal organization correlates to motility and invasiveness of malignant mesothelioma cells.
Cancers (Basel) 13:685.1-685.20(2021)

PubMed=34663305; DOI=10.1186/s12935-021-02248-5; PMCID=PMC8525006
Tatsuhiro Sato, Hayao Nakanishi, Ken Akao, Maho Okuda, Satomi Mukai, Tohru Kiyono, Yoshitaka Sekido;
Three newly established immortalized mesothelial cell lines exhibit morphological phenotypes corresponding to malignant mesothelioma epithelioid, intermediate, and sarcomatoid types, respectively.
Cancer Cell Int. 21:546.1-546.11(2021)

Cross-references
Cell line collections (Providers) ATCC; CRL-9444
BCRC; 60352
CLS; 305269
IZSLER; BS CL 214
Cell line databases/resources CLO; CLO_0007680
Biological sample resources BioSample; SAMN03471216
Encyclopedic resources Wikidata; Q54905322
Experimental variables resources EFO; EFO_0001218
Gene expression databases GEO; GSM49613
GEO; GSM139667
GEO; GSM139668
GEO; GSM139669
GEO; GSM139760
GEO; GSM139761
GEO; GSM433109
GEO; GSM433127
GEO; GSM433145
GEO; GSM3684948
Proteomic databases PRIDE; PXD033058
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number27