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Cellosaurus JSC-1 (CVCL_3728)

[Text version]
Cell line name JSC-1
Synonyms JSC1; JSC
Accession CVCL_3728
Secondary accession CVCL_B054
Resource Identification Initiative To cite this cell line use: JSC-1 (RRID:CVCL_3728)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Caucasian.
Doubling time: 48 hours (PubMed=11024147).
Microsatellite instability: Stable (MSS) (Sanger).
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Transformant: NCBI_TaxID; 37296; Human herpesvirus 8 (HHV-8/KSHV).
Omics: Genomics; ChIP-seq; H3K27ac.
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; Array-based CGH.
Omics: Variations; SNP array analysis.
Misspelling: JCS-1; Note=Occasionally.
Derived from site: In situ; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (Cosmic-CLP=1327769; DepMap=ACH-002253).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.79
Native American0.09
East Asian, North0.94
East Asian, South0
South Asian1.9
European, North65.05
European, South31.24
Disease Primary effusion lymphoma (NCIt: C6915)
Primary effusion lymphoma (ORDO: Orphanet_48686)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 52Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-2769; Cosmic-CLP=1327769

Markers:
AmelogeninX,Y
CSF1PO10,11
D5S81812
D7S8209
D13S3179,14
D16S53911,12
TH016,9
TPOX8,11
vWA14,18

Run an STR similarity search on this cell line
Web pages Info; IdeaConnection; -; https://www.ideaconnection.com/patents/6066-JSC1.html
Publications

PubMed=11024147; DOI=10.1128/JVI.74.21.10187-10193.2000; PMCID=PMC102057
Jennifer S. Cannon, Dolores Ciufo, Anita L. Hawkins, Constance A. Griffin, Michael Joseph Borowitz, Gary S. Hayward, Richard F. Ambinder;
A new primary effusion lymphoma-derived cell line yields a highly infectious Kaposi's sarcoma herpesvirus-containing supernatant.
J. Virol. 74:10187-10193(2000)

PubMed=15613351; DOI=10.1128/JVI.79.2.1244-1251.2005; PMCID=PMC538532
Wen Fan, Darya Bubman, Amy Chadburn, William J. Harrington Jr., Ethel Cesarman, Daniel M. Knowles;
Distinct subsets of primary effusion lymphoma can be identified based on their cellular gene expression profile and viral association.
J. Virol. 79:1244-1251(2005)

PubMed=17121789; DOI=10.1128/JVI.01757-06; PMCID=PMC1797584
Christin E. Burd, Sang-Hoon Sin, Dirk P. Dittmer;
Functional p53 signaling in Kaposi's sarcoma-associated herpesvirus lymphomas: implications for therapy.
J. Virol. 81:1912-1922(2007)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=21685375; DOI=10.1182/blood-2010-12-323659; PMCID=PMC3158728
Debasmita Roy, Sang-Hoon Sin, Blossom Damania, Dirk P. Dittmer;
Tumor suppressor genes FHIT and WWOX are deleted in primary effusion lymphoma (PEL) cell lines.
Blood 118:e32-e39(2011)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

PubMed=36094314; DOI=10.1128/JVI.00739-22; PMCID=PMC9517713
Wei-Yue Ding, Chong Wang, Yohei Narita, Hong-Bo Wang, Merrin Man Long Leong, Alvin Huang, Yi-Fei Liao, Xue-Feng Liu, Yusuke Okuno, Hiroshi Kimura, Benjamin Elison Gewurz ...Show all 15 authors... , Ming-Xian Teng, Shui-Lin Jin, Yoshitaka Sato, Bo Zhao; Show fewer authors
The Epstein-Barr virus enhancer interaction landscapes in virus-associated cancer cell lines.
J. Virol. 96:e00739.22.1-e00739.22.11(2022)

Cross-references
Cell line collections (Providers) ATCC; CRL-2769 - Discontinued
ATCC; JHU-32 - Discontinued
Cell line databases/resources CLO; CLO_0007039
cancercelllines; CVCL_3728
Cell_Model_Passport; SIDM00688
Cosmic-CLP; 1327769
DepMap; ACH-002253
LINCS_LDP; LCL-1959
Biological sample resources BioSample; SAMN03471783
Chemistry resources GDSC; 1327769
PharmacoDB; JSC1_711_2019
Encyclopedic resources Wikidata; Q54899065
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM634739
GEO; GSM710424
GEO; GSM710440
GEO; GSM827379
GEO; GSM1669964
GEO; GSM3150247
Polymorphism and mutation databases Cosmic; 1588564
IARC_TP53; 23657
Progenetix; CVCL_3728
Proteomic databases PRIDE; PXD012087
PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number39