Cellosaurus logo
expasy logo

Cellosaurus I 9.2 (CVCL_3725)

[Text][XML][JSON]
Cell line name I 9.2
Synonyms I9.2; I9-2; I-9-2
Accession CVCL_3725
Resource Identification Initiative To cite this cell line use: I 9.2 (RRID:CVCL_3725)
Comments Population: Caucasian.
Characteristics: Functionally defective for caspase-8 (PubMed=10616904).
Transformant: ChEBI; CHEBI_132982; Acridine half-mustard dihydrochloride (6-chloro-9-[3-(2-chloroethylamino)propylamino]-2-methoxyacridine dihydrochloride; Acridine mutagen ICR 191).
Omics: Genomics; DNA methylation analysis.
Omics: Transcriptomics; Microarray.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Mutation; HGNC; HGNC:959; BAX; Simple; p.Glu41Argfs*19 (c.121delG); ClinVar=VCV000009512; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:959; BAX; Simple; p.Glu41Glyfs*33 (c.121dupG); ClinVar=VCV000009511; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg505Cys (c.1513C>T); ClinVar=VCV000069961; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6079; INPP5D; Simple; p.Gln345Ter (c.1033C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6079; INPP5D; Simple; c.1097+1065_1097+1112del47; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7325; MSH2; Simple; p.Arg711Ter (c.2131C>T); ClinVar=VCV000090903; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7329; MSH6; Simple; p.Phe1088Serfs*2 (c.3261delC); ClinVar=VCV000089363; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000043589; Zygosity=Heterozygous (from parent cell line).
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1061 (Jurkat clone A3)
Sex of cell Male
Age at sampling 14Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-2571

Markers:
AmelogeninX
CSF1PO11,12
D2S133819,23
D3S135815,17
D5S8189
D7S8208,9.2
D8S117912,14
D13S3178,11
D16S53911
D18S5113,21
D19S43314,14.2
D21S1131.2,33.2
FGA19,21
Penta D11
Penta E10,12
TH016,9.3
TPOX8,10
vWA18

Run an STR similarity search on this cell line
Publications

PubMed=10616904
Peter Juo, Michele Sue-Ann Woo, Calvin Jay Kuo, Paola Signorelli, Hans-Peter Biemann, Yusuf A. Hannun, John Blenis;
FADD is required for multiple signaling events downstream of the receptor Fas.
Cell Growth Differ. 10:797-804(1999)

Cross-references
Cell line collections (Providers) ATCC; CRL-2571
Cell line databases/resources CLO; CLO_0004317
cancercelllines; CVCL_3725
Cell_Model_Passport; SIDM01224
LINCS_LDP; LCL-1028
Anatomy/cell type resources BTO; BTO_0003683
Biological sample resources BioSample; SAMN03471679
Chemistry resources PharmacoDB; I92_649_2019
Encyclopedic resources Wikidata; Q54897066
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM1669925
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number27