Cellosaurus cell line FHC (CVCL

Cellosaurus FHC (CVCL_3688)

[Text version]

Cell line name

FHC

Synonyms

Fetal Human Colon

Accession

CVCL_3688

Resource Identification Initiative

To cite this cell line use: FHC (RRID:CVCL_3688)

Comments

Characteristics: Forms solid tumors after transplantation into SCID mice.
Doubling time: ~62 hours (PubMed=6519668).
Karyotypic information: Is hypotriploid, has >20 copies of the 8q23~8q24.3 region containing MYC (PubMed=20193843).
Omics: Transcriptomics; Microarray.
Derived from site: In situ; Fetal colon; UBERON=UBERON_0001155.
Cell type: Epithelial cell of colon; CL=CL_0011108.

Sequence variations

Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Unspecified (PubMed=20193843).

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Sex of cell

Male

Age at sampling

13FW

Category

Spontaneously immortalized cell line

STR profile

Source(s): AddexBio=P0009022/4980; ATCC=CRL-1831

Markers:

Amelogenin	X,Y
CSF1PO	11,12
D2S1338	17,20
D3S1358	16,18
D5S818	12,13
D7S820	8,12
D8S1179	14,17
D13S317	12,13
D16S539	9,11
D18S51	15,17
D19S433	13,14.2
D21S11	28,29
FGA	21,24.3
Penta D	9,13
Penta E	7,14
TH01	6,9.3
TPOX	8,11
vWA	16

Publications

PubMed=6519668; DOI=10.1007/BF02619632
Khwaja Mohammad Siddiqui, Dharam P. Chopra;
Primary and long term epithelial cell cultures from human fetal normal colonic mucosa.
In Vitro 20:859-868(1984)

PubMed=20193843; DOI=10.1016/j.cancergencyto.2009.11.009
Karel Soucek, Pavla Gajduskova, Marie Brazdova, Martina Hyzd'alova, Lenka Koci, David Vydra, Radek Trojanec, Zuzana Pernicova, Lenka Lentvorska, Marian Hajduch, Jirina Hofmanova, Alois Kozubik;
Fetal colon cell line FHC exhibits tumorigenic phenotype, complex karyotype, and TP53 gene mutation.
Cancer Genet. Cytogenet. 197:107-116(2010)

Cross-references

Cell line collections (Providers)

AddexBio; P0009022/4980
ATCC; CRL-1831
KCB; KCB 2017068YJ
KCB; KCB 2018026YJ

Cell line databases/resources

CLO; CLO_0003236
CCRID; 5301HUM-KCB18026YJ

Anatomy/cell type resources

BTO; BTO_0003808

Biological sample resources

BioSample; SAMN03471253

Chemistry resources

ChEMBL-Cells; CHEMBL3308603
ChEMBL-Targets; CHEMBL614654
PubChem_Cell_line; CVCL_3688

Encyclopedic resources