Cellosaurus logo
expasy logo

Cellosaurus BZR (CVCL_3658)

[Text][XML][JSON]
Cell line name BZR
Accession CVCL_3658
Resource Identification Initiative To cite this cell line use: BZR (RRID:CVCL_3658)
Comments Group: Patented cell line.
Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-9483.
Characteristics: Highly tumorigenic derivative of BEAS-2B.
Genetic integration: Method=Transfection; Gene=UniProtKB; P01115; Harvey murine sarcoma virus H-Ras (V-Ha-ras).
Transformant: Ad12-SV40 hybrid virus.
Derived from site: In situ; Lung, bronchus, epithelium; UBERON=UBERON_0002031.
Cell type: Epithelial cell of bronchus; CL=CL_0002328.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0168 (BEAS-2B)
Children:
CVCL_1G00 (BZR-T33)
Sex of cell Male
Age at sampling Age unspecified
Category Transformed cell line
STR profile Source(s): ATCC=CRL-9483

Markers:
AmelogeninX,Y
CSF1PO9,12
D5S81812,13
D7S82010,13
D13S31713
D16S53912
TH017,9.3
TPOX6,11
vWA17,18

Run an STR similarity search on this cell line
Publications

PubMed=2855021; DOI=10.1002/mc.2940010303
Paul A. Amstad, Roger Robert Reddel, Andrea M.A. Pfeifer, Louise B. Malan-Shibley, George E. Mark 3rd, Curtis Craig Harris;
Neoplastic transformation of a human bronchial epithelial cell line by a recombinant retrovirus encoding viral Harvey ras.
Mol. Carcinog. 1:151-160(1988)

Patent=US4885238
Roger Robert Reddel, Ke Yang, Johng Sik Rhim, Douglas E. Brash, Robert T. Su, John F. Lechner, Brenda Isen Gerwin, Curtis Craig Harris, Paul A. Amstad;
Immortalized human bronchial epithelial mesothelial cell lines.
Patent number US4885238, 05-Dec-1989

PubMed=2539488; DOI=10.1093/jnci/81.8.587
R. Daniel Bonfil, Roger Robert Reddel, Hitoshi Ura, Reuven Reich, Rafael Fridman, Curtis Craig Harris, Andres J.P. Klein-Szanto;
Invasive and metastatic potential of a v-Ha-ras-transformed human bronchial epithelial cell line.
J. Natl. Cancer Inst. 81:587-594(1989)

DOI=10.1007/978-1-4612-0411-4_25
Teresa A. Lehman, Curtis Craig Harris;
Neoplastic transformation and suppression of transformation of human bronchial epithelial cells in vitro.
(In book chapter) Neoplastic transformation in human cell system. Mechanism of carcinogenesis; Rhim, Johng Sik & Dritschilo, Anatoly (eds.); pp.251-258; Humana Press; New York; USA (1990)

Patent=US5443954
Roger Robert Reddel, Ke Yang, Johng Sik Rhim, Douglas E. Brash, Robert T. Su, John F. Lechner, Brenda Isen Gerwin, Curtis Craig Harris, Paul A. Amstad;
Immortalized non-tumorigenic human bronchial epithelial cell lines.
Patent number US5443954, 22-Aug-1995

Cross-references
Cell line collections (Providers) ATCC; CRL-9483
Cell line databases/resources CLO; CLO_0002067
Encyclopedic resources Wikidata; Q54799725
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number20