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Cellosaurus SW579 (CVCL_3603)

[Text version]
Cell line name SW579
Synonyms SW-579; SW 579
Accession CVCL_3603
Resource Identification Initiative To cite this cell line use: SW579 (RRID:CVCL_3603)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: KuDOS 95 cell line panel.
From: Scott and White Clinic; Temple; USA.
Population: Caucasian.
Omics: Genomics; Mitochondrial genome sequencing.
Omics: Genomics; Whole exome sequencing.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Thyroid gland; UBERON=UBERON_0002046.
Sequence variations
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (PubMed=31068700).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ile255Ser (c.764T>G); ClinVar=VCV000376622; Zygosity=Homozygous (PubMed=1516062; DepMap=ACH-000163).
HLA typing Source: PubMed=26589293
Class I
HLA-AA*02:01,02:01
HLA-BB*07:43,51:01
HLA-CC*15:02,15:02
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.11
Native American1.95
East Asian, North0.43
East Asian, South0
South Asian0.91
European, North63.94
European, South32.66
Disease Thyroid gland squamous cell carcinoma (NCIt: C46008)
Thyroid carcinoma (ORDO: Orphanet_100088)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_1120 (CGTH-W-1)
Sex of cell Male
Age at sampling 59Y
Category Cancer cell line
STR profile Source(s): ATCC=HTB-107; CCRID; CLS=300346; IZSLER=BS TCL 121

Markers:
AmelogeninX
CSF1PO13
D2S133817,18
D3S135815,18
D5S81811
D7S8208,9
D8S117911,13
D13S31713
D16S53911
D18S5115,17,18
D19S43313,14
D21S1129,31
FGA21,24
Penta D9,12
Penta E11,12
TH018,9.3
TPOX8,10
vWA14,18

Run an STR similarity search on this cell line
Publications

PubMed=327080; DOI=10.1093/jnci/59.1.221
Jorgen Fogh, Jens M. Fogh, Thomas Orfeo;
One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice.
J. Natl. Cancer Inst. 59:221-226(1977)

PubMed=833871; DOI=10.1093/jnci/58.2.209
Jorgen Fogh, William C. Wright, James D. Loveless;
Absence of HeLa cell contamination in 169 cell lines derived from human tumors.
J. Natl. Cancer Inst. 58:209-214(1977)

PubMed=6220172
Nicholas C. Dracopoli, Jorgen Fogh;
Polymorphic enzyme analysis of cultured human tumor cell lines.
J. Natl. Cancer Inst. 70:469-476(1983)

PubMed=3518877; DOI=10.3109/07357908609038260
Jorgen Fogh;
Human tumor lines for cancer research.
Cancer Invest. 4:157-184(1986)

PubMed=1516062
Katsuhiko Yoshimoto, Hiroyuki Iwahana, Ayumi Fukuda, Toshiaki Sano, Shiro Saito, Mitsuo Itakura;
Role of p53 mutations in endocrine tumorigenesis: mutation detection by polymerase chain reaction-single strand conformation polymorphism.
Cancer Res. 52:5061-5064(1992)

DOI=10.1016/B978-0-12-333530-2.50007-1
Thomas E. Carey;
Head and neck tumor cell lines.
(In book chapter) Atlas of human tumor cell lines; Hay, Robert J. & Park, Jae-Gahb & Gazdar, Adi F. (eds.); pp.79-120; Academic Press; New York; USA (1994)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Jordi Ginesta Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan, Adam A. Margolin, Sungjoon Kim, Christopher J. Wilson, Joseph Lehar, Gregory V. Kryukov, Dmitriy Sonkin, Anupama Reddy ...Show all 61 authors... , Manway Liu, Lauren Murray, Michael F. Berger, John E. Monahan, Paula Morais, Jodi Meltzer, Adam Korejwa, Judit Jane-Valbuena, Felipa A. Mapa, Joseph Thibault, Eva Bric-Furlong, Pichai Raman, Aaron Shipway, Ingo H. Engels, Jill Cheng, Guo-Ying K. Yu, Jian-Jun Yu, Peter Aspesi Jr., Melanie de Silva, Kalpana Jagtap, Michael D. Jones, Li Wang, Charles Hatton, Emanuele Palescandolo, Supriya Gupta, Scott Mahan, Carrie Sougnez, Robert C. Onofrio, Ted Liefeld, Laura E. MacConaill, Wendy Winckler, Michael Reich, Nan-Xin Li, Jill P. Mesirov, Stacey B. Gabriel, Gad Getz, Kristin Ardlie, Vivien Chan, Vic E. Myer, Barbara L. Weber, Jeff Porter, Markus Warmuth, Peter Finan, Jennifer L. Harris, Matthew Langer Meyerson, Todd Robert Golub, Michael P. Morrissey, William Raj Sellers, Robert Schlegel, Levi Alexander Garraway; Show fewer authors
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Jelle Scholtalbers, Sebastian Boegel, Thomas Bukur, Marius Byl, Sebastian Goerges, Patrick Sorn, Martin Loewer, Ugur Sahin, John C. Castle;
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=29066502; DOI=10.1530/ERC-17-0288
Willem E. Corver, Joris Demmers, Jan Oosting, Shima Sahraeian, Arnoud Boot, Dina Ruano, Tom van Wezel, Hans Morreau;
ROS-induced near-homozygous genomes in thyroid cancer.
Endocr. Relat. Cancer 25:83-97(2018)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31443247; DOI=10.3390/cancers11081185; PMCID=PMC6721552
Mehtap Derya Aydemirli, Willem E. Corver, Ruben Beuk, Paul Roepman, Nienke Solleveld-Westerink, Tom van Wezel, Ellen H.W. Kapiteijn, Hans Morreau;
Targeted treatment options of recurrent radioactive iodine refractory Hurthle cell cancer.
Cancers (Basel) 11:1185.1-1185.16(2019)

Cross-references
Cell line collections (Providers) ATCC; HTB-107
BCRC; 60412
CLS; 300346
IZSLER; BS TCL 121
KCB; KCB 2013004YJ
Cell line databases/resources CLO; CLO_0009220
cancercelllines; CVCL_3603
CCRID; 1101HUM-PUMC000264
CCRID; 3101HUMTCHu125
Cell_Model_Passport; SIDM01167
DepMap; ACH-000163
IGRhCellID; SW579
Biological sample resources BioSample; SAMN10988339
Chemistry resources PharmacoDB; SW579_1540_2019
Encyclopedic resources Wikidata; Q54971179
Gene expression databases ArrayExpress; E-MTAB-2770
GEO; GSM887676
GEO; GSM888768
GEO; GSM1374931
GEO; GSM1374932
Polymorphism and mutation databases Cosmic; 1005454
Cosmic; 1006467
Cosmic; 1017791
Cosmic; 1041672
Cosmic; 1094773
Cosmic; 1339924
IARC_TP53; 1308
LiGeA; CCLE_771
Progenetix; CVCL_3603
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number36