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Cellosaurus 8E5(CEM) (CVCL_3484)

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Cell line name 8E5(CEM)
Synonyms 8E5/LAV; 8E5
Accession CVCL_3484
Resource Identification Initiative To cite this cell line use: 8E5(CEM) (RRID:CVCL_3484)
Comments Group: Patented cell line.
Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-8993.
Population: Caucasian.
Virology: HIV-1 producing cell line.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Gene fusion; HGNC; HGNC:13222; BCL11B + HGNC; HGNC:2488; NKX2-5; Name(s)=NKX2.5-BCL11B (from parent cell line).
  • Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg465Cys (c.1393C>T); ClinVar=VCV000376414; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:3765; FLT3; Simple; p.Ala627Thr (c.1879G>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Leu1593_Arg1594insProArgLeuProHisAsnSerSerPheHisPheLeu (c.4780_4781ins36); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Pro2412Thr (c.7234C>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (from parent cell line).
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_6244 (CEM A3.01)
Sex of cell Female
Age at sampling 3Y11M
Category Cancer cell line
STR profile Source(s): ATCC=CRL-3617

Markers:
AmelogeninX
CSF1PO9,11
D5S81812
D7S8209,13
D13S31712,13
D16S53910,13
TH016,7
TPOX8
vWA17,20

Run an STR similarity search on this cell line
Publications

PubMed=3014036; DOI=10.1084/jem.164.1.280; PMCID=PMC2188205
Thomas M. Folks, Douglas Powell, Marilyn Lightfoote, Scott Koenig, Anthony Stephen Fauci, Steven Benn, Arnold B. Rabson, Daryl Daugherty, Howard Eliot Gendelman, Malcolm David Hoggan Jr., Sundararajan Venkatesan, Malcolm A. Martin;
Biological and biochemical characterization of a cloned Leu-3- cell surviving infection with the acquired immune deficiency syndrome retrovirus.
J. Exp. Med. 164:280-290(1986)

Patent=US4752565
Thomas M. Folks, David M. Powell, Malcolm A. Martin;
Cell line producing AIDS viral antigens without producing infectious virus particles.
Patent number US4752565, 21-Jun-1988

Cross-references
Cell line collections (Providers) ATCC; CRL-3617
ATCC; CRL-8993 - Discontinued
BEI_Resources; ARP-95
Cell line databases/resources CLO; CLO_0001521
cancercelllines; CVCL_3484
Biological sample resources BioSample; SAMN03471213
Encyclopedic resources Wikidata; Q54605508
Entry history
Entry creation04-Apr-2012
Last entry update19-Dec-2024
Version number24