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Cellosaurus Lec1 (CVCL_3440)

[Text version]

Cell line name Lec1
Synonyms CHO-Lec1; CHO Lec1; Pro-Lec1.3C; Pro-5 Lec1.3c; Pro-5WgaRI3C
Accession CVCL_3440
Resource Identification Initiative To cite this cell line use: Lec1 (RRID:CVCL_3440)
Comments Derived from sampling site: Ovary.
Sequence variations
  • Mutation; UniProtKB; Q924C0; Mgat1; Simple; p.Gln339Arg; Zygosity=Unspecified (PubMed=8910379).
  • Mutation; UniProtKB; Q924C0; Mgat1; Simple; p.Lys401Arg; Zygosity=Unspecified (PubMed=8910379).
Species of origin Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) (NCBI Taxonomy: 10029)
Hierarchy Parent: CVCL_4382 (CHO Pro-5)
Sex of cell Female
Age at sampling Adult
Category Spontaneously immortalized cell line
Web pages https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/c/cell-lines-detail-202.html

PubMed=1182798; DOI=10.1016/0092-8674(75)90002-1
Stanley P., Caillibot V., Siminovitch L.
Selection and characterization of eight phenotypically distinct lines of lectin-resistant Chinese hamster ovary cell.
Cell 6:121-128(1975)

PubMed=3785164; DOI=10.1128/mcb.6.4.1268-1275.1986
Ripka J., Shin S.-I., Stanley P.
Decreased tumorigenicity correlates with expression of altered cell surface carbohydrates in Lec9 CHO cells.
Mol. Cell. Biol. 6:1268-1275(1986)

PubMed=8910379; DOI=10.1074/jbc.271.44.27818
Puthalakath H., Burke J., Gleeson P.A.
Glycosylation defect in Lec1 Chinese hamster ovary mutant is due to a point mutation in N-acetylglucosaminyltransferase I gene.
J. Biol. Chem. 271:27818-27822(1996)

PubMed=24078077; DOI=10.1007/s00418-013-1146-1
Dong Z., Zuber C., Pierce M., Stanley P., Roth J.
Reduction in Golgi apparatus dimension in the absence of a residential protein, N-acetylglucosaminyltransferase V.
Histochem. Cell Biol. 141:153-164(2014)

Cell line collections ATCC; CRL-1735
CLS; 305010
Cell line databases/resources CLO; CLO_0007301
Encyclopedic resources Wikidata; Q54902418
Entry history
Entry creation04-Apr-2012
Last entry update22-Sep-2022
Version number16