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Cellosaurus SUM44PE (CVCL_3424)

[Text version]
Cell line name SUM44PE
Synonyms Sum44PE; SUM-44PE; SUM 44PE; SUM-44 PE; SUM-44; SUM 44; SUM44; Sum44; 44PE
Accession CVCL_3424
Resource Identification Initiative To cite this cell line use: SUM44PE (RRID:CVCL_3424)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: JWGray breast cancer cell line panel.
Characteristics: ER-positive, PR-negative and ERBB2-negative.
Doubling time: 85.10 hours (JWGray panel).
Omics: Array-based CGH.
Omics: CNV analysis.
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: miRNA expression profiling.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Mutation; HGNC; 1748; CDH1; Simple; p.Phe423Leufs*8 (c.1269delT); ClinVar=VCV002035493; Zygosity=Homozygous (PubMed=19593635).
  • Mutation; HGNC; 11998; TP53; Simple; p.Glu28fs*16 (c.82_84del3insCA); Zygosity=Unspecified (PubMed=16541312).
HLA typing Source: PubMed=25960936
Class I
HLA-BB*14:02,56:29
HLA-CC*08:04,08:04
Disease Invasive breast lobular carcinoma (NCIt: C7950)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): DepMap=ACH-001395

Markers:
AmelogeninX
CSF1PO11,12
D3S135814,15
D5S81811
D7S8209,11
D8S117914
D13S3179
D16S53911
D18S5117
D21S1132.2
FGA22,24
Penta D9
Penta E10,18
TH016,9
TPOX8
vWA15,17

Run an STR similarity search on this cell line
Web pages https://bioivt.com/sum-breast-cancer-cell-lines/
https://www.synapse.org/#!Synapse:syn2346643/wiki/62255
Publications

PubMed=8425198
Ethier S.P., Mahacek M.L., Gullick W.J., Frank T.S., Weber B.L.
Differential isolation of normal luminal mammary epithelial cells and breast cancer cells from primary and metastatic sites using selective media.
Cancer Res. 53:627-635(1993)

PubMed=10424408; DOI=10.1023/A:1006135331912
Ignatoski K.M.W., Ethier S.P.
Constitutive activation of pp125fak in newly isolated human breast cancer cell lines.
Breast Cancer Res. Treat. 54:173-182(1999)

PubMed=10604729; DOI=10.1038/sj.bjc.6695007; PMCID=PMC2362964
Forozan F., Veldman R., Ammerman C.A., Parsa N.Z., Kallioniemi A.H., Kallioniemi O.-P., Ethier S.P.
Molecular cytogenetic analysis of 11 new breast cancer cell lines.
Br. J. Cancer 81:1328-1334(1999)

PubMed=10969801
Forozan F., Mahlamaki E.H., Monni O., Chen Y.-D., Veldman R., Jiang Y., Gooden G.C., Ethier S.P., Kallioniemi A.H., Kallioniemi O.-P.
Comparative genomic hybridization analysis of 38 breast cancer cell lines: a basis for interpreting complementary DNA microarray data.
Cancer Res. 60:4519-4525(2000)

PubMed=12353263; DOI=10.1002/gcc.10107
Popovici C., Basset C., Bertucci F., Orsetti B., Adelaide J., Mozziconacci M.-J., Conte N., Murati A., Ginestier C., Charafe-Jauffret E., Ethier S.P., Lafage-Pochitaloff M., Theillet C., Birnbaum D., Chaffanet M.
Reciprocal translocations in breast tumor cell lines: cloning of a t(3;20) that targets the FHIT gene.
Genes Chromosomes Cancer 35:204-218(2002)

PubMed=12800145; DOI=10.1002/gcc.10218
Adelaide J., Huang H.-E., Murati A., Alsop A.E., Orsetti B., Mozziconacci M.-J., Popovici C., Ginestier C., Letessier A., Basset C., Courtay-Cahen C., Jacquemier J., Theillet C., Birnbaum D., Edwards P.A.W., Chaffanet M.
A recurrent chromosome translocation breakpoint in breast and pancreatic cancer cell lines targets the neuregulin/NRG1 gene.
Genes Chromosomes Cancer 37:333-345(2003)

PubMed=15677628; DOI=10.1093/carcin/bgi032
Gorringe K.L., Chin S.-F., Pharoah P.D.P., Staines J.M., Oliveira C., Edwards P.A.W., Caldas C.
Evidence that both genetic instability and selection contribute to the accumulation of chromosome alterations in cancer.
Carcinogenesis 26:923-930(2005)

PubMed=16397213; DOI=10.1158/0008-5472.CAN-05-2853
Elstrodt F., Hollestelle A., Nagel J.H.A., Gorin M., Wasielewski M., van den Ouweland A.M.W., Merajver S.D., Ethier S.P., Schutte M.
BRCA1 mutation analysis of 41 human breast cancer cell lines reveals three new deleterious mutants.
Cancer Res. 66:41-45(2006)

PubMed=16541312; DOI=10.1007/s10549-006-9186-z
Wasielewski M., Elstrodt F., Klijn J.G.M., Berns E.M.J.J., Schutte M.
Thirteen new p53 gene mutants identified among 41 human breast cancer cell lines.
Breast Cancer Res. Treat. 99:97-101(2006)

PubMed=17157791; DOI=10.1016/j.ccr.2006.10.008; PMCID=PMC2730521
Neve R.M., Chin K., Fridlyand J., Yeh J., Baehner F.L., Fevr T., Clark L., Bayani N., Coppe J.-P., Tong F., Speed T., Spellman P.T., DeVries S., Lapuk A., Wang N.J., Kuo W.-L., Stilwell J.L., Pinkel D., Albertson D.G., Waldman F.M., McCormick F., Dickson R.B., Johnson M.D., Lippman M.E., Ethier S.P., Gazdar A.F., Gray J.W.
A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes.
Cancer Cell 10:515-527(2006)

PubMed=19582160; DOI=10.1371/journal.pone.0006146; PMCID=PMC2702084
Kao J., Salari K., Bocanegra M., Choi Y.-L., Girard L., Gandhi J., Kwei K.A., Hernandez-Boussard T., Wang P., Gazdar A.F., Minna J.D., Pollack J.R.
Molecular profiling of breast cancer cell lines defines relevant tumor models and provides a resource for cancer gene discovery.
PLoS ONE 4:E6146-E6146(2009)

PubMed=19593635; DOI=10.1007/s10549-009-0460-8
Hollestelle A., Nagel J.H.A., Smid M., Lam S., Elstrodt F., Wasielewski M., Ng S.S., French P.J., Peeters J.K., Rozendaal M.J., Riaz M., Koopman D.G., ten Hagen T.L.M., de Leeuw B.H.C.G.M., Zwarthoff E.C., Teunisse A., van der Spek P.J., Klijn J.G.M., Dinjens W.N.M., Ethier S.P., Clevers H.C., Jochemsen A.G., den Bakker M.A., Foekens J.A., Martens J.W.M., Schutte M.
Distinct gene mutation profiles among luminal-type and basal-type breast cancer cell lines.
Breast Cancer Res. Treat. 121:53-64(2010)

PubMed=23401782; DOI=10.1155/2013/872743; PMCID=PMC3562669
Barnabas N., Cohen D.
Phenotypic and molecular characterization of MCF10DCIS and SUM breast cancer cell lines.
Int. J. Breast Cancer 2013:872743.1-872743.16(2013)

PubMed=23601657; DOI=10.1186/bcr3415; PMCID=PMC3672661
Riaz M., van Jaarsveld M.T.M., Hollestelle A., Prager-van der Smissen W.J.C., Heine A.A.J., Boersma A.W.M., Liu J.-J., Helmijr J.C.A., Ozturk B., Smid M., Wiemer E.A.C., Foekens J.A., Martens J.W.M.
miRNA expression profiling of 51 human breast cancer cell lines reveals subtype and driver mutation-specific miRNAs.
Breast Cancer Res. 15:R33.1-R33.17(2013)

PubMed=24176112; DOI=10.1186/gb-2013-14-10-r110; PMCID=PMC3937590
Daemen A., Griffith O.L., Heiser L.M., Wang N.J., Enache O.M., Sanborn Z., Pepin F., Durinck S., Korkola J.E., Griffith M., Hur J.S., Huh N., Chung J., Cope L., Fackler M.J., Umbricht C.B., Sukumar S., Seth P., Sukhatme V.P., Jakkula L.R., Lu Y.-L., Mills G.B., Cho R.J., Collisson E.A., van 't Veer L.J., Spellman P.T., Gray J.W.
Modeling precision treatment of breast cancer.
Genome Biol. 14:R110.1-R110.14(2013)

PubMed=24425047; DOI=10.1158/0008-5472.CAN-13-2779; PMCID=PMC3955299
Sikora M.J., Cooper K.L., Bahreini A., Luthra S., Wang G.-Y., Chandran U.R., Davidson N.E., Dabbs D.J., Welm A.L., Oesterreich S.
Invasive lobular carcinoma cell lines are characterized by unique estrogen-mediated gene expression patterns and altered tamoxifen response.
Cancer Res. 74:1463-1474(2014)

PubMed=25960936; DOI=10.4161/21624011.2014.954893; PMCID=PMC4355981
Boegel S., Lower M., Bukur T., Sahin U., Castle J.C.
A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.
OncoImmunology 3:e954893.1-e954893.12(2014)

PubMed=25757734; DOI=10.1186/s13058-015-0517-z; PMCID=PMC4320436
Christgen M., Derksen P.W.B.
Lobular breast cancer: molecular basis, mouse and cellular models.
Breast Cancer Res. 17:16.1-16.9(2015)

PubMed=30228172; DOI=10.1158/0008-5472.CAN-18-1416; PMCID=PMC6507416
Tasdemir N., Bossart E.A., Li Z.-Q., Zhu L., Sikora M.J., Levine K.M., Jacobsen B.M., Tseng G.C.-C., Davidson N.E., Oesterreich S.
Comprehensive phenotypic characterization of human invasive lobular carcinoma cell lines in 2D and 3D cultures.
Cancer Res. 78:6209-6222(2018)

PubMed=32715085; DOI=10.1038/s41523-020-0173-z; PMCID=PMC7374090
Ethier S.P., Guest S.T., Garrett-Mayer E., Armeson K., Wilson R.C., Duchinski K., Couch D., Gray J.W., Kappler C.S.
Development and implementation of the SUM breast cancer cell line functional genomics knowledge base.
NPJ Breast Cancer 6:30.1-30.14(2020)

Cross-references
Cell line databases/resources cancercelllines; CVCL_3424
Cell_Model_Passport; SIDM01835
DepMap; ACH-001395
LINCS_HMS; 51122
SLKBase; 219
Anatomy/cell type resources BTO; BTO:0005389
Chemistry resources PharmacoDB; SUM44PE_1517_2019
Encyclopedic resources Wikidata; Q54970850
Experimental variables resources EFO; EFO_0001245
Gene expression databases ArrayExpress; E-TABM-157
ArrayExpress; E-TABM-244
GEO; GSM115108
GEO; GSM217603
GEO; GSM320179
GEO; GSM350531
GEO; GSM421886
GEO; GSM481300
GEO; GSM847438
GEO; GSM847505
GEO; GSM984233
GEO; GSM1053740
GEO; GSM1172997
GEO; GSM1226542
GEO; GSM1226543
GEO; GSM1226544
GEO; GSM1226545
GEO; GSM1226546
GEO; GSM1226547
GEO; GSM1226548
GEO; GSM1226549
GEO; GSM1226550
GEO; GSM1226551
GEO; GSM1226552
GEO; GSM1226553
GEO; GSM1226554
GEO; GSM1226555
GEO; GSM1226556
GEO; GSM1226557
GEO; GSM1226558
GEO; GSM1226559
GEO; GSM1226560
GEO; GSM1226561
GEO; GSM1661990
Polymorphism and mutation databases Cosmic; 997937
Cosmic; 1289408
Cosmic; 1460237
IARC_TP53; 24364
Progenetix; CVCL_3424
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number35