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Cellosaurus SUM102PT (CVCL_3421)

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Cell line name SUM102PT
Synonyms SUM-102PT; SUM 102PT; SUM-102; SUM 102; SUM102; Sum102; 102PT
Accession CVCL_3421
Resource Identification Initiative To cite this cell line use: SUM102PT (RRID:CVCL_3421)
Comments Group: Triple negative breast cancer (TNBC) cell line.
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: JWGray breast cancer cell line panel.
Doubling time: 112.71 hours (JWGray panel).
Omics: Genomics; Whole exome sequencing.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; miRNA profiling; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; Array-based CGH.
Omics: Variations; CNV analysis.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Breast; UBERON=UBERON_0000310.
Sequence variations
Disease Breast carcinoma (NCIt: C4872)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 57Y
Category Cancer cell line
STR profile Source(s): DepMap=ACH-001388

Markers:
AmelogeninX
CSF1PO12,13
D3S135815,17
D5S81811,12
D7S82010,12
D8S117914
D13S31711,12
D16S53911,14
D18S5113
D21S1129,30
FGA24,27
Penta D10,11
Penta E13,16
TH016,9.3
TPOX8
vWA15,18

Run an STR similarity search on this cell line
Web pages Info; Synapse; JWGray panel; https://www.synapse.org/#!Synapse:syn2346643/wiki/62255
Provider; BioIVT/Asterand; -; https://bioivt.com/sum-breast-cancer-cell-lines/
Publications

PubMed=9041204
Carolyn I. Sartor, Michele Lauren Dziubinski, Chao-Lan Yu, Richard Jove, Stephen P. Ethier;
Role of epidermal growth factor receptor and STAT-3 activation in autonomous proliferation of SUM-102PT human breast cancer cells.
Cancer Res. 57:978-987(1997)

PubMed=10424408; DOI=10.1023/A:1006135331912
Kathleen M. Woods Ignatoski, Stephen P. Ethier;
Constitutive activation of pp125fak in newly isolated human breast cancer cell lines.
Breast Cancer Res. Treat. 54:173-182(1999)

PubMed=10604729; DOI=10.1038/sj.bjc.6695007; PMCID=PMC2362964
Farahnaz Forozan, Robin Veldman, Cheryl A. Ammerman, Nasser Z. Parsa, Anne H. Kallioniemi, Olli-Pekka Kallioniemi, Stephen P. Ethier;
Molecular cytogenetic analysis of 11 new breast cancer cell lines.
Br. J. Cancer 81:1328-1334(1999)

PubMed=10969801
Farahnaz Forozan, Eija H. Mahlamaki, Outi Monni, Yi-Dong Chen, Robin Veldman, Yuan Jiang, Gerald C. Gooden, Stephen P. Ethier, Anne H. Kallioniemi, Olli-Pekka Kallioniemi;
Comparative genomic hybridization analysis of 38 breast cancer cell lines: a basis for interpreting complementary DNA microarray data.
Cancer Res. 60:4519-4525(2000)

PubMed=15677628; DOI=10.1093/carcin/bgi032
Kylie Louise Gorringe, Suet-Feung Chin, Paul D.P. Pharoah, Joanne M. Staines, Carla Oliveira, Paul A.W. Edwards, Carlos Caldas;
Evidence that both genetic instability and selection contribute to the accumulation of chromosome alterations in cancer.
Carcinogenesis 26:923-930(2005)

PubMed=16397213; DOI=10.1158/0008-5472.CAN-05-2853
Fons Elstrodt, Antoinette Hollestelle, Jord H.A. Nagel, Michael Gorin, Marijke Wasielewski, Ans M.W. van den Ouweland, Sofia Diana Merajver, Stephen P. Ethier, Mieke Schutte;
BRCA1 mutation analysis of 41 human breast cancer cell lines reveals three new deleterious mutants.
Cancer Res. 66:41-45(2006)

PubMed=16541312; DOI=10.1007/s10549-006-9186-z
Marijke Wasielewski, Fons Elstrodt, Jan G.M. Klijn, Els M.J.J. Berns, Mieke Schutte;
Thirteen new p53 gene mutants identified among 41 human breast cancer cell lines.
Breast Cancer Res. Treat. 99:97-101(2006)

PubMed=19582160; DOI=10.1371/journal.pone.0006146; PMCID=PMC2702084
Jessica Kao, Keyan Salari, Melanie Bocanegra, Yoon-La Choi, Luc Girard, Jeet Gandhi, Kevin A. Kwei, Tina Hernandez-Boussard, Pei Wang, Adi F. Gazdar, John D. Minna, Jonathan R. Pollack;
Molecular profiling of breast cancer cell lines defines relevant tumor models and provides a resource for cancer gene discovery.
PLoS ONE 4:e6146.1-e6146.16(2009)

PubMed=19593635; DOI=10.1007/s10549-009-0460-8
Antoinette Hollestelle, Jord H.A. Nagel, Marcel Smid, Suzanne Lam, Fons Elstrodt, Marijke Wasielewski, Ser Sue Ng, Pim J. French, Justine K. Peeters, Marieke J. Rozendaal, Muhammad Riaz ...Show all 26 authors... , Daphne G. Koopman, Timo L.M. ten Hagen, Bertie H.C.G.M. de Leeuw, Ellen C. Zwarthoff, Amina F.A.S. Teunisse, Peter J. van der Spek, Jan G.M. Klijn, Winand N.M. Dinjens, Stephen P. Ethier, Hans Cornelius Clevers, Aart G. Jochemsen, Michael A. den Bakker, John A. Foekens, John W.M. Martens, Mieke Schutte; Show fewer authors
Distinct gene mutation profiles among luminal-type and basal-type breast cancer cell lines.
Breast Cancer Res. Treat. 121:53-64(2010)

PubMed=21778573; DOI=10.3233/BD-2010-0307; PMCID=PMC3532890
Kathryn J. Chavez, Sireesha V. Garimella, Stanley Lipkowitz;
Triple negative breast cancer cell lines: one tool in the search for better treatment of triple negative breast cancer.
Breast Dis. 32:35-48(2010)

PubMed=23401782; DOI=10.1155/2013/872743; PMCID=PMC3562669
Nandita Barnabas, Dalia Cohen;
Phenotypic and molecular characterization of MCF10DCIS and SUM breast cancer cell lines.
Int. J. Breast Cancer 2013:872743.1-872743.16(2013)

PubMed=23601657; DOI=10.1186/bcr3415; PMCID=PMC3672661
Muhammad Riaz, Marijn T.M. van Jaarsveld, Antoinette Hollestelle, Wendy J.C. Prager-van der Smissen, Anouk A.J. Heine, Antonius W.M. Boersma, Jing-Jing Liu, Jean C.A. Helmijr, Bahar Ozturk, Marcel Smid, Erik A.C. Wiemer ...Show all 13 authors... , John A. Foekens, John W.M. Martens; Show fewer authors
miRNA expression profiling of 51 human breast cancer cell lines reveals subtype and driver mutation-specific miRNAs.
Breast Cancer Res. 15:R33.1-R33.17(2013)

PubMed=24162158; DOI=10.1007/s10549-013-2743-3; PMCID=PMC3832776
Aleix Prat, Olga Karginova, Joel S. Parker, Cheng Fan, Xia-Ping He, Lisa M. Bixby, J. Chuck Harrell, Erick Roman, Barbara Adamo, Melissa A. Troester, Charles M. Perou;
Characterization of cell lines derived from breast cancers and normal mammary tissues for the study of the intrinsic molecular subtypes.
Breast Cancer Res. Treat. 142:237-255(2013)

PubMed=24176112; DOI=10.1186/gb-2013-14-10-r110; PMCID=PMC3937590
Anneleen Daemen, Obi L. Griffith, Laura M. Heiser, Nicholas J. Wang, Oana M. Enache, Zachary Sanborn, Francois Pepin, Steffen Durinck, James E. Korkola, Malachi Griffith, Joe S. Hur ...Show all 27 authors... , Nam Huh, Jongsuk Chung, Leslie Cope, Mary Jo Fackler, Christopher Benedict Umbricht, Saraswati Sukumar, Pankaj Seth, Vikas P. Sukhatme, Lakshmi R. Jakkula, Yi-Ling Lu, Gordon B. Mills, Raymond J. Cho, Eric A. Collisson, Laura J. van 't Veer, Paul T. Spellman, Joe W. Gray; Show fewer authors
Modeling precision treatment of breast cancer.
Genome Biol. 14:R110.1-R110.14(2013)

PubMed=32715085; DOI=10.1038/s41523-020-0173-z; PMCID=PMC7374090
Stephen P. Ethier, Stephen T. Guest, Elizabeth Garrett-Mayer, Kent Armeson, Robert C. Wilson, Kathryn Duchinski, Daniel Couch, Joe W. Gray, Christiana S. Kappler;
Development and implementation of the SUM breast cancer cell line functional genomics knowledge base.
NPJ Breast Cancer 6:30.1-30.14(2020)

Cross-references
Cell line databases/resources cancercelllines; CVCL_3421
Cell_Model_Passport; SIDM01837
DepMap; ACH-001388
LINCS_HMS; 51120
SLKBase; 241
Anatomy/cell type resources BTO; BTO_0005387
Chemistry resources PharmacoDB; SUM102PT_1514_2019
Encyclopedic resources Wikidata; Q54970826
Gene expression databases GEO; GSM217598
GEO; GSM350537
GEO; GSM421888
GEO; GSM1008914
GEO; GSM1172990
GEO; GSM1215255
GEO; GSM1401675
Polymorphism and mutation databases Cosmic; 904388
Cosmic; 997922
Cosmic; 1046939
Cosmic; 1287928
Cosmic; 1289410
IARC_TP53; 24338
Progenetix; CVCL_3421
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number35