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Cellosaurus KE-39 (CVCL_3385)

[Text version]
Cell line name KE-39
Synonyms KE39
Accession CVCL_3385
Resource Identification Initiative To cite this cell line use: KE-39 (RRID:CVCL_3385)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Population: Japanese.
Doubling time: ~38.4 hours (PubMed=7599112).
Omics: Deep exome analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000027.
Sequence variations
  • Mutation; HGNC; 2514; CTNNB1; Simple; p.Asp32Asn (c.94G>A); ClinVar=VCV000376228; Zygosity=Heterozygous (DepMap).
  • Mutation; HGNC; 11998; TP53; Simple; p.Val272Leu (c.814G>T); ClinVar=VCV000012358; Zygosity=Homozygous (DepMap).
Genome ancestry Source: PubMed=30894373

Origin% genome
African1.5
Native American0
East Asian, North89.52
East Asian, South4.53
South Asian0
European, North0
European, South4.45
Disease Gastric adenocarcinoma (NCIt: C4004)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 77Y
Category Cancer cell line
STR profile Source(s): PubMed=25877200; RCB

Markers:
AmelogeninX
CSF1PO13
D2S133822
D3S135817
D5S81810
D7S82011
D8S117911,16
D13S3178,10
D16S53911
D18S5114,15
D19S43314.2,16.2
D21S1130
FGA22,23
Penta D11
Penta E18,23
TH017 (PubMed=25877200)
7,9.3 (RCB)
TPOX9,11
vWA14

Run an STR similarity search on this cell line
Publications

PubMed=7599112
Uesugi H., Yamashita K., Atari E., Shinoda H., Nishiyama T., Okayasu I., Yasuda S.
Establishment and characterization of strain KE-39 derived from human gastric cancer.
Hum. Cell 7:227-232(1994)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=24587255; DOI=10.1371/journal.pone.0090155
Endo F., Nishizuka S.S., Kume K., Ishida K., Katagiri H., Ishida K., Sato K., Iwaya T., Koeda K., Wakabayashi G.
A compensatory role of NF-kappaB to p53 in response to 5-FU-based chemotherapy for gastric cancer cell lines.
PLoS ONE 9:E90155-E90155(2014)

PubMed=24807215; DOI=10.1038/ncomms4830
Liu J.-F., McCleland M.L., Stawiski E.W., Gnad F., Mayba O., Haverty P.M., Durinck S., Chen Y.-J., Klijn C., Jhunjhunwala S., Lawrence M., Liu H.-B., Wan Y.-N., Chopra V.S., Yaylaoglu M.B., Yuan W.-L., Ha C., Gilbert H.N., Reeder J., Pau G., Stinson J., Stern H.M., Manning G., Wu T.D., Neve R.M., de Sauvage F.J., Modrusan Z., Seshagiri S., Firestein R., Zhang Z.-M.
Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancer.
Nat. Commun. 5:3830.1-3830.8(2014)

PubMed=25877200; DOI=10.1038/nature14397
Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M., Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S., Neve R.M.
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections (Providers) RCB; RCB1434
Cell line databases/resources CLO; CLO_0050802
cancercelllines; CVCL_3385
Cell_Model_Passport; SIDM01582
DepMap; ACH-000507
Biological sample resources BioSample; SAMN03470990
BioSample; SAMN03472139
BioSample; SAMN10987859
Chemistry resources PharmacoDB; KE39_741_2019
Encyclopedic resources Wikidata; Q54899716
Gene expression databases ArrayExpress; E-MTAB-2770
GEO; GSM887204
GEO; GSM888277
Polymorphism and mutation databases Cosmic; 1187280
IARC_TP53; 28288
LiGeA; CCLE_164
Progenetix; CVCL_3385
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number22