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Cellosaurus GLC-82 (CVCL_3371)

[Text version]
Cell line name GLC-82
Synonyms Glc-82; GLC82; Gejiu Lung Carcinoma-82
Accession CVCL_3371
Resource Identification Initiative To cite this cell line use: GLC-82 (RRID:CVCL_3371)
Comments Problematic cell line: Contaminated. Shown to be a HeLa derivative (PubMed=26116706). Originally thought to originate from a 32 year old female patient with a lung adenocarcinoma.
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00572.
Population: African American.
Doubling time: 48 hours (PubMed=4006684).
Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
Miscellaneous: Formerly the CCRID database had an entry describing this cell line (3111C0001CCC000067). It was one of the sources for the STR profile of this entry.
Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
Genome ancestry Source: PubMed=30894373

Origin% genome
Native American1.23
East Asian, North2.62
East Asian, South0
South Asian0
European, North15.73
European, South14.1
Disease Human papillomavirus-related cervical adenocarcinoma (NCIt: C27677)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0030 (HeLa)
CVCL_6906 (HAC-84)
Sex of cell Female
Age at sampling 30Y6M
Category Cancer cell line
STR profile Source(s): CCRID; PubMed=26116706

Penta D8,15
Penta E7,17

Run an STR similarity search on this cell line
Web pages https://iclac.org/wp-content/uploads/Cross-Contaminations_v12_distribution.xlsx

Liang M.-D., Jia W., Hu M.-Y., Wang Z.-X., Liu G.-Y., Zhou K.-M.
Establishment of lung adenocarcinoma cell line in Gejiu (GLC-82) and study of its biologic properties.
Zhonghua Zhong Liu Za Zhi 7:81-82(1985)

Liang M.-D., Hu M.-Y., Jia W., Wang Z.-X., Mong F.-H., Zhou K.-M.
Establishment of a human lung alveolar cancer cell strain and its characteristics.
Zhonghua Zhong Liu Za Zhi 9:336-338(1987)

PubMed=3471311; DOI=10.1016/0165-4608(87)90066-5
Fan Y.-S., Li P.
Cytogenetic studies of four human lung adenocarcinoma cell lines.
Cancer Genet. Cytogenet. 26:317-325(1987)

PubMed=20545000; DOI=10.3724/SP.J.1141.2010.02113
Peng K.-J., Wang J.-H., Su W.-T., Wang X.-C., Yang F.-T., Nie W.-H.
Characterization of two human lung adenocarcinoma cell lines by reciprocal chromosome painting.
Dong Wu Xue Yan Jiu 31:113-121(2010)

PubMed=25433501; DOI=10.1007/s13277-014-2888-7
Miao Z.-F., Li W.-Y., Wang Z.-N., Zhao T.-T., Xu Y.-Y., Song Y.-X., Huang J.-Y., Xu H.-M.
Lung cancer cells induce senescence and apoptosis of pleural mesothelial cells via transforming growth factor-beta1.
Tumor Biol. 36:2657-2665(2015)

PubMed=26116706; DOI=10.1096/fj.14-266718
Ye F., Chen C.-G., Qin J., Liu J., Zheng C.-Y.
Genetic profiling reveals an alarming rate of cross-contamination among human cell lines used in China.
FASEB J. 29:4268-4272(2015)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cell line collections (Providers) ICLC; HTL98006 - Discontinued
KCB; KCB 86017YJ
KCB; KCB 200435YJ
Cell line databases/resources CLO; CLO_0003505
Cell_Model_Passport; SIDM01939
DepMap; ACH-001071
TOKU-E; 3607
Anatomy/cell type resources BTO; BTO:0004113
Chemistry resources PharmacoDB; GLC82_406_2019
Encyclopedic resources Wikidata; Q54835925
Polymorphism and mutation databases Cosmic; 753557
IARC_TP53; 21345
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number27