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Cellosaurus Ty-82 (CVCL_3220)

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Cell line name Ty-82
Synonyms TY-82; TY82; Ty82
Accession CVCL_3220
Resource Identification Initiative To cite this cell line use: Ty-82 (RRID:CVCL_3220)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Population: Japanese.
Doubling time: ~30 hours (Note=Lot 02152010), ~53 hours (Note=Lot 09082016) (JCRB=JCRB1330).
Omics: Genomics; Whole genome sequencing.
Omics: Transcriptomics; RNAseq.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
Disease NUT carcinoma (NCIt: C45716)
Thymic undifferentiated carcinoma (NCIt: C35718)
NUT midline carcinoma (ORDO: Orphanet_443167)
Thymic carcinoma (ORDO: Orphanet_99868)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 22Y
Category Cancer cell line
STR profile Source(s): JCRB=JCRB1330

Markers:
AmelogeninX
CSF1PO11,12
D5S8189,11
D7S82012,13
D13S31711
D16S5399,11
TH016,9.3
TPOX9,11
vWA17,19

Run an STR similarity search on this cell line
Publications

PubMed=1730520; DOI=10.1002/ijc.2910500216
Tetsuya Kuzume, Ichiro Kubonishi, Seisho Takeuchi, Tamotsu Takeuchi, Jun Iwata, Hiroshi Sonobe, Yuji Ohtsuki, Isao Miyoshi;
Establishment and characterization of a thymic carcinoma cell line (Ty-82) carrying t(15;19)(q15;p13) chromosome abnormality.
Int. J. Cancer 50:259-264(1992)

PubMed=21447744; DOI=10.1158/0008-5472.CAN-10-3513; PMCID=PMC3070805
Brian E. Schwartz, Matthias D. Hofer, Madeleine E. Lemieux, Daniel Evan Bauer, Michael J. Cameron, Nathan H. West, Elin S. Agoston, Nicolas Reynoird, Saadi Khochbin, Tan A. Ince, Amanda L. Christie ...Show all 19 authors... , Katherine A. Janeway, Sara Oakes Vargas, Antonio Rafael Perez-Atayde, Jon Christopher Aster, Stephen Earl Sallan, Andrew L. Kung, James E. Bradner, Christopher Alexander French; Show fewer authors
Differentiation of NUT midline carcinoma by epigenomic reprogramming.
Cancer Res. 71:2686-2696(2011)

PubMed=24736545; DOI=10.1158/0008-5472.CAN-13-2658; PMCID=PMC4097982
Ran-Ran Wang, Wei Liu, Christine M. Helfer, James E. Bradner, Jason L. Hornick, Susan M. Janicki, Christopher Alexander French, Jian-Xin You;
Activation of SOX2 expression by BRD4-NUT oncogenic fusion drives neoplastic transformation in NUT midline carcinoma.
Cancer Res. 74:3332-3343(2014)

PubMed=28203693; DOI=10.1093/annonc/mdw686; PMCID=PMC5378225
Jake June-Koo Lee, Sandra Louzada, Yohan An, Sun Young Kim, Seolyong Kim, Jeonghwan Youk, Seongyeol Park, Sun Hoe Koo, Bhumsuk Keam, Yoon Kyung Jeon, Ja-Lok Ku ...Show all 14 authors... , Feng-Tang Yang, Tae Min Kim, Young Seok Ju; Show fewer authors
Complex chromosomal rearrangements by single catastrophic pathogenesis in NUT midline carcinoma.
Ann. Oncol. 28:890-897(2017)

PubMed=29348827; DOI=10.18632/oncotarget.22862; PMCID=PMC5762512
Anja Stirnweiss, Joyce Oommen, Rishi S. Kotecha, Ursula R. Kees, Alex H. Beesley;
Molecular-genetic profiling and high-throughput in vitro drug screening in NUT midline carcinoma-an aggressive and fatal disease.
Oncotarget 8:112313-112329(2017)

Cross-references
Cell line collections (Providers) JCRB; JCRB1330
JCRB; NIHS0541 - Discontinued
Cell line databases/resources DepMap; ACH-001676
Encyclopedic resources Wikidata; Q54973446
Gene expression databases FANTOM5_SSTAR; 10803-111A2
GEO; GSM577206
Sequence databases EGA; EGAD00001003117
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number18