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Cellosaurus T.Tn (CVCL_3175)

[Text version]
Cell line name T.Tn
Synonyms T_Tn; T-Tn; TTn; T Tn; T-Tn6; TTN
Accession CVCL_3175
Resource Identification Initiative To cite this cell line use: T.Tn (RRID:CVCL_3175)
Comments Population: Japanese.
Characteristics: Established from the original tumor through transplantation in nude mice.
Doubling time: 27 hours (Note=At 52th passage) (DOI=10.5794/jjoms.36.307); 32-35 hours (Note=Lot 01212003), ~28 hours (Note=Lot 01262015) (JCRB=JCRB0261).
Omics: Transcriptomics; Microarray.
Omics: Variations; SNP array analysis.
Derived from site: Metastatic; Bone, jaw, mandible; UBERON=UBERON_0001684.
Sequence variations
Disease Esophageal squamous cell carcinoma (NCIt: C4024)
Squamous cell carcinoma of the esophagus (ORDO: Orphanet_99977)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_3174 ! T.T
Sex of cell Male
Age at sampling 67Y
Category Cancer cell line
STR profile Source(s): JCRB=JCRB0261

Markers:
AmelogeninX,Y
CSF1PO11,13
D5S8188,10
D7S82011
D13S31710,11
D16S5399,11
TH019
TPOX8,11
vWA16,17

Run an STR similarity search on this cell line
Publications

DOI=10.5794/jjoms.36.307
Kikuo Takahashi, Harusachi Kanazawa, Chen-Tzer Chan, Takaya Hosono, Masaaki Takahara, Ken-ichi Sato;
A case of esophageal carcinoma metastatic to the mandible and characterization of two cell lines (T-T and T-Tn) established from the oral tumor.
Nihon Koku Geka Gakkai Zasshi 36:307-316(1990)

PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D
Li-Qun Jia, Motonobu Osada, Chikashi Ishioka, Makio Gamo, Shuntaro Ikawa, Takao Suzuki, Hideki Shimodaira, Tomohito Niitani, Toshio Kudo, Mitoshi Akiyama, Narimiti Kimura ...Show all 18 authors... , Mitsuyoshi Matsuo, Hiroshi Mizusawa, Noriho Tanaka, Hideki Koyama, Masayoshi Namba, Ryunosuke Kanamaru, Toshio Kuroki; Show fewer authors
Screening the p53 status of human cell lines using a yeast functional assay.
Mol. Carcinog. 19:243-253(1997)

PubMed=15885884; DOI=10.1016/j.canlet.2005.03.036
Paulisally Hau-Yi Lo, Alfred Chi-Chung Leung, Wen-Jun Xiong, Simon Ying-Kit Law, Fuh-Mei Duh, Michael I. Lerman, Eric John Stanbridge, Maria Li Lung;
Expression of candidate chromosome 3p21.3 tumor suppressor genes and down-regulation of BLU in some esophageal squamous cell carcinomas.
Cancer Lett. 234:184-192(2006)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

Cross-references
Cell line collections (Providers) JCRB; JCRB0261
Cell line databases/resources CLO; CLO_0009936
cancercelllines; CVCL_3175
LINCS_LDP; LCL-1562
Biological sample resources BioSample; SAMN03471669
Encyclopedic resources Wikidata; Q54971375
Gene expression databases GEO; GSM827521
GEO; GSM1374967
Polymorphism and mutation databases Cosmic; 873391
Cosmic; 923185
Cosmic; 1612902
IARC_TP53; 21668
Progenetix; CVCL_3175
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number28