• Gene fusion; HGNC; HGNC:3508; EWSR1 + HGNC; HGNC:3749; FLI1; Name(s)=EWSR1-FLI1, EWS-FLI1; Note=Type 1 fusion (Ex7/Ex6) (PubMed=7591257; PubMed=9738976).
  

PubMed=2513302; DOI=10.1111/j.1349-7006.1989.tb01727.x; PMCID=PMC5917846
Chieko Homma, Yasuhiko Kaneko, Ki-ichi Sekine, Shin-ichi Hara, Jun-ichi Hata, Masaharu Sakurai;
Establishment and characterization of a small round cell sarcoma cell line, SCCH-196, with t(11;22)(q24;q12).
Jpn. J. Cancer Res. 80:861-865(1989)

PubMed=8221663
Hiroaki Komuro, Yasuhide Hayashi, Machiko Kawamura, Kenshi Hayashi, Yasuhiko Kaneko, Shigehiko Kamoshita, Ryoji Hanada, Keiko Yamamoto, Teruaki Hongo, Masao Yamada, Yoshiaki Tsuchida;
Mutations of the p53 gene are involved in Ewing's sarcomas but not in neuroblastomas.
Cancer Res. 53:5284-5288(1993)

PubMed=7591257; DOI=10.1002/ijc.2910630407
Kohmei Ida, Shigetoshi Kobayashi, Tomohiko Taki, Ryoji Hanada, Fumio Bessho, Shunji Yamamori, Toru Sugimoto, Misao Ohki, Yasuhide Hayashi;
EWS-FLI-1 and EWS-ERG chimeric mRNAs in Ewing's sarcoma and primitive neuroectodermal tumor.
Int. J. Cancer 63:500-504(1995)

PubMed=9738976; DOI=10.1111/j.1349-7006.1998.tb03274.x; PMCID=PMC5921883
Fumihiko Urano, Akihiro Umezawa, Hiroki Yabe, Wei Hong, Koichi Yoshida, Kei Fujinaga, Jun-ichi Hata;
Molecular analysis of Ewing's sarcoma: another fusion gene, EWS-E1AF, available for diagnosis.
Jpn. J. Cancer Res. 89:703-711(1998)

PubMed=12054564; DOI=10.1016/S0006-291X(02)00129-8
Hiroki Yabe, Mariko Fukuma, Fumihiko Urano, Koichi Yoshida, Shingo Kato, Yoshiaki Toyama, Jun-ichi Hata, Akihiro Umezawa;
Lack of matrix metalloproteinase (MMP)-1 and -3 expression in Ewing sarcoma may be due to loss of accessibility of the MMP regulatory element to the specific fusion protein in vivo.
Biochem. Biophys. Res. Commun. 293:61-71(2002)