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Cellosaurus NOMO-1/ADM (CVCL_3077)

[Text version]
Cell line name NOMO-1/ADM
Accession CVCL_3077
Resource Identification Initiative To cite this cell line use: NOMO-1/ADM (RRID:CVCL_3077)
Comments Population: Japanese.
Doubling time: ~1.5 days (Note=Lot 10032003) (JCRB=JCRB1069).
Selected for resistance to: ChEBI; CHEBI:28748; Doxorubicin (Adriablastin; Adriamycin).
Omics: SNP array analysis.
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
  • Gene fusion; HGNC; 7132; KMT2A + HGNC; 7136; MLLT3; Name(s)=KMT2A-MLLT3, MLL-MLLT3, MLL-AF9 (from parent cell line).
  • Mutation; HGNC; 3373; EP300; Simple; c.730-10T>C; dbSNP=rs201058616; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Cys242Alafs*5 (c.723delC) (p.S241fs); ClinVar=VCV001074338; Zygosity=Heterozygous (from parent cell line).
Disease Adult acute monocytic leukemia (NCIt: C8263)
Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1609 (NOMO-1)
Sex of cell Female
Age at sampling 31Y
Category Cancer cell line
Publications

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

Cross-references
Cell line collections (Providers) JCRB; JCRB1069
Cell line databases/resources CLO; CLO_0009852
cancercelllines; CVCL_3077
LINCS_LDP; LCL-1064
Encyclopedic resources Wikidata; Q54930899
Gene expression databases GEO; GSM827275
Polymorphism and mutation databases Progenetix; CVCL_3077
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number23