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Cellosaurus Onda 11 (CVCL_3076)

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Cell line name Onda 11
Synonyms Onda-11; no.11; no-11; NO11; Case 3
Accession CVCL_3076
Resource Identification Initiative To cite this cell line use: Onda 11 (RRID:CVCL_3076)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Japanese.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; CRISPR screening.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Brain, right parietal lobe; UBERON=UBERON_0002803.
Sequence variations
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Gln17del (c.49_51delCAA); Zygosity=Unspecified (PubMed=10551321).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gly245Ser (c.733G>A); ClinVar=VCV000012365; Zygosity=Unspecified (PubMed=8878451).
Genome ancestry Source: PubMed=30894373

Origin% genome
African1.72
Native American1.06
East Asian, North76.42
East Asian, South17.02
South Asian0
European, North1.56
European, South2.21
Disease Glioblastoma (NCIt: C3058)
Glioblastoma (ORDO: Orphanet_360)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 64Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=908450; DepMap=ACH-001606; JCRB=IFO50369; JCRB=JCRB1605

Markers:
AmelogeninX
CSF1PO9,10,12 (JCRB=JCRB1605)
10,12 (Cosmic-CLP=908450; DepMap=ACH-001606; JCRB=IFO50369)
D3S135817
D5S81810,11
D7S82011 (Cosmic-CLP=908450)
11,12 (DepMap=ACH-001606; JCRB=IFO50369)
11,12,13 (JCRB=JCRB1605)
D8S117910
D13S3178 (Cosmic-CLP=908450; DepMap=ACH-001606; JCRB=IFO50369)
8,9 (JCRB=JCRB1605)
D16S53911
D18S5113,15
D21S1130,31
FGA23
Penta D12,13
Penta E13
TH016,8 (JCRB=JCRB1605)
8 (Cosmic-CLP=908450; DepMap=ACH-001606; JCRB=IFO50369)
TPOX8 (Cosmic-CLP=908450; DepMap=ACH-001606; JCRB=IFO50369)
8,11 (JCRB=JCRB1605)
vWA14,15,17 (JCRB=JCRB1605)
14,17 (Cosmic-CLP=908450; DepMap=ACH-001606; JCRB=IFO50369)

Run an STR similarity search on this cell line
Publications

PubMed=3188836; DOI=10.1007/BF00686381
Kiyoshi Onda, Ryuichi Tanaka, Kazuo Washiyama, Norio Takeda, Toshiro Kumanishi;
Correlation of DNA ploidy and morphological features of human glioma cell cultures with the establishment of cell lines.
Acta Neuropathol. 76:433-440(1988)

CLPUB00089
Kiyoshi Onda, Kazuo Washiyama, Ryuichi Tanaka, Akiko Nishiyama, Hiroshi Usui, Toshiro Kumanishi;
GFAP-positive human glioma cell lines: no.11, no.10.
Hum. Cell 3:251-252(1990)

PubMed=8878451; DOI=10.1111/j.1349-7006.1996.tb02118.x; PMCID=PMC5921198
Shu-Jing Zhang, Sumio Endo, Hisashi Koga, Tomio Ichikawa, Xue-Lian Feng, Kiyoshi Onda, Kazuo Washiyama, Toshiro Kumanishi;
A comparative study of glioma cell lines for p16, p15, p53 and p21 gene alterations.
Jpn. J. Cancer Res. 87:900-907(1996)

PubMed=10551321; DOI=10.1111/j.1349-7006.1999.tb00838.x; PMCID=PMC5926156
Shu-Jing Zhang, Sumio Endo, Tomio Ichikawa, Jun-ichi Yoshimura, Kiyoshi Onda, Ryuichi Tanaka, Kazuo Washiyama, Toshiro Kumanishi;
Rare-type mutations of MMAC1 tumor suppressor gene in human glioma cell lines and their tumors of origin.
Jpn. J. Cancer Res. 90:934-941(1999)

PubMed=16232199; DOI=10.1111/j.1349-7006.2005.00099.x; PMCID=PMC11159392
Kuniyasu Saigusa, Naoya Hashimoto, Hitoshi Tsuda, Sana Yokoi, Motohiko Maruno, Toshiki Yoshimine, Masaru Aoyagi, Kikuo Ohno, Issei Imoto, Johji Inazawa;
Overexpressed Skp2 within 5p amplification detected by array-based comparative genomic hybridization is associated with poor prognosis of glioblastomas.
Cancer Sci. 96:676-683(2005)

PubMed=18415661; DOI=10.1007/s10014-007-0226-0
Yoshiyuki Tanaka, Shu-Jing Zhang, Hiroshi Terasaki, Hisashi Koga, Sumio Endo, Hiroshi Usui, Kazuo Washiyama, Toshiro Kumanishi, Yuji Uematsu, Toru Itakura;
Frequent and variable abnormalities in p14 tumor suppressor gene in glioma cell lines.
Brain Tumor Pathol. 25:9-17(2008)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa ...Show all 22 authors... , Jonathan Hinton, Ciara Fahey, Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=30971826; DOI=10.1038/s41586-019-1103-9
Fiona M. Behan, Francesco Iorio, Gabriele Picco, Emanuel Goncalves, Charlotte M. Beaver, Giorgia Migliardi, Rita Santos, Yanhua Rao, Francesco Sassi, Marika Pinnelli, Rizwan Ansari ...Show all 25 authors... , Sarah Harper, David Adam Jackson, Rebecca McRae, Rachel Pooley, Piers Wilkinson, Dieudonne J. van der Meer, David Dow, Carolyn A. Buser-Doepner, Andrea Bertotti, Livio Trusolino, Euan Alexander Stronach, Julio Saez-Rodriguez, Kosuke Yusa, Mathew J. Garnett; Show fewer authors
Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.
Nature 568:511-516(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) JCRB; IFO50369
JCRB; JCRB1605
RCB; RCB4500
Cell line databases/resources CLO; CLO_0009899
cancercelllines; CVCL_3076
Cell_Model_Passport; SIDM00573
CGH-DB; 152-1
Cosmic-CLP; 908450
DepMap; ACH-001606
LINCS_LDP; LCL-1387
Biological sample resources BioSample; SAMN03481112
CRISP screens repositories BioGRID_ORCS_Cell_line; 969
Chemistry resources ChEMBL-Cells; CHEMBL3308224
ChEMBL-Targets; CHEMBL2366326
GDSC; 908450
PharmacoDB; no11_1164_2019
PubChem_Cell_line; CVCL_3076
Encyclopedic resources Wikidata; Q54936401
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM1670282
Polymorphism and mutation databases Cosmic; 687580
Cosmic; 908450
Cosmic; 2367542
IARC_TP53; 21592
IARC_TP53; 23806
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number40