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Cellosaurus NALL-1 (CVCL_3039)

[Text version]
Cell line name NALL-1
Synonyms Null-cell Acute Lymphoblastic Leukemia-1
Accession CVCL_3039
Resource Identification Initiative To cite this cell line use: NALL-1 (RRID:CVCL_3039)
Comments Population: Japanese.
Doubling time: 88 hours (Note=In RPMI 1640 + 20% HCS), 72 hours (Note=In RPMI 1640 + 20% FCS) (PubMed=200333).
Microsatellite instability: Stable (MSS) (PubMed=10739008; PubMed=11226526).
Omics: Deep quantitative proteome analysis.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene fusion; HGNC; 3495; ETV6 + HGNC; 8619; PAX5; Name(s)=PAX5-ETV6 (PubMed=35354797).
Disease Childhood acute lymphoblastic leukemia (NCIt: C3168)
Acute lymphoblastic leukemia (ORDO: Orphanet_513)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 14Y
Category Cancer cell line
STR profile Source(s): COG; JCRB=JCRB1332

Markers:
AmelogeninX
CSF1PO10
D2S133817,19
D3S135816
D5S81810,12
D7S82012,13
D8S117912,13
D13S31711,12
D16S53911,13
D18S5116,19
D19S43313,14.2
D21S1130,32.2
FGA19,23
TH016,7
TPOX8
vWA17

Run an STR similarity search on this cell line
Publications

PubMed=197412; DOI=10.1038/267843a0
Miyoshi I., Hiraki S., Tsubota T., Kubonishi I., Matsuda Y., Nakayama T., Kishimoto H., Kimura I., Masuji H.
Human B cell, T cell and null cell leukaemic cell lines derived from acute lymphoblastic leukaemias.
Nature 267:843-844(1977)

PubMed=200333; DOI=10.1002/1097-0142(197711)40:5<2131::AID-CNCR2820400523>3.0.CO;2-V
Hiraki S., Miyoshi I., Kubonishi I., Matsuda Y., Nakayama T., Kishimoto H., Masuji H.
Human leukemic 'null' cell line (NALL-1).
Cancer 40:2131-2135(1977)

PubMed=155647; PMCID=PMC1457255
Han T., Minowada J.
Use of stimulating capacity of mixed lymphocyte reaction (MLR-S) as a possible marker for the cell-origin of null-cell acute lymphoblastic leukaemia.
Immunology 35:333-339(1978)

PubMed=6097530; DOI=10.1007/BF02619636
Yourno J., Samsonoff W.A., Willey A., Burkhart P., Lizzi F., Tartaglia A.
NALL-1, an acute lymphoblastic leukemia cell line with peroxidase activity.
In Vitro 20:884-888(1984)

PubMed=2985879; DOI=10.1016/0145-2126(85)90084-0
Drexler H.G., Gaedicke G., Minowada J.
Isoenzyme studies in human leukemia-lymphoma cell lines -- 1 carboxylic esterase.
Leuk. Res. 9:209-229(1985)

PubMed=3159941; DOI=10.1016/0145-2126(85)90134-1
Drexler H.G., Gaedicke G., Minowada J.
Isoenzyme studies in human leukemia-lymphoma cell lines -- III Beta-hexosaminidase (E.C. 3.2.1.30).
Leuk. Res. 9:549-559(1985)

PubMed=3874327; DOI=10.1016/0145-2126(85)90133-x
Drexler H.G., Gaedicke G., Minowada J.
Isoenzyme studies in human leukemia-lymphoma cells lines -- II. Acid phosphatase.
Leuk. Res. 9:537-548(1985)

PubMed=8957066; DOI=10.1111/j.1349-7006.1996.tb03112.x; PMCID=PMC5920998
Kawasaki N., Matsuo Y., Yoshino T., Yanai H., Oka T., Teramoto N., Liu C., Kondo E., Minowada J., Akagi T.
Metastatic potential of lymphoma/leukemia cell lines in SCID mice is closely related to expression of CD44.
Jpn. J. Cancer Res. 87:1070-1077(1996)

PubMed=9680106; DOI=10.1016/S0145-2126(98)00050-2
Matsuo Y., Drexler H.G.
Establishment and characterization of human B cell precursor-leukemia cell lines.
Leuk. Res. 22:567-579(1998)

PubMed=9738977; DOI=10.1111/j.1349-7006.1998.tb03275.x; PMCID=PMC5921886
Takizawa J., Suzuki R., Kuroda H., Utsunomiya A., Kagami Y., Joh T., Aizawa Y., Ueda R., Seto M.
Expression of the TCL1 gene at 14q32 in B-cell malignancies but not in adult T-cell leukemia.
Jpn. J. Cancer Res. 89:712-718(1998)

PubMed=10739008; DOI=10.1016/S0145-2126(99)00182-4
Inoue K., Kohno T., Takakura S., Hayashi Y., Mizoguchi H., Yokota J.
Frequent microsatellite instability and BAX mutations in T cell acute lymphoblastic leukemia cell lines.
Leuk. Res. 24:255-262(2000)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=11226526; DOI=10.1016/S0145-2126(00)00121-1
Inoue K., Kohno T., Takakura S., Hayashi Y., Mizoguchi H., Yokota J.
Corrigendum to: Frequent microsatellite instability and BAX mutations in T cell acute lymphoblastic leukemia cell lines Leukemia Research 24 (2000), 255-262.
Leuk. Res. 25:275-278(2001)

PubMed=11986953; DOI=10.1038/sj.leu.2402485
O'Donnell P.H., Guo W.-X., Reynolds C.P., Maurer B.J.
N-(4-hydroxyphenyl)retinamide increases ceramide and is cytotoxic to acute lymphoblastic leukemia cell lines, but not to non-malignant lymphocytes.
Leukemia 16:902-910(2002)

PubMed=35354797; DOI=10.1038/s41467-022-29224-5; PMCID=PMC8967900
Leo I.R., Aswad L., Stahl M., Kunold E., Post F., Erkers T., Struyf N., Mermelekas G., Joshi R.N., Gracia-Villacampa E., Ostling P., Kallioniemi O.-P., Pokrovskaja Tamm K., Siavelis I., Lehtio J., Vesterlund M., Jafari R.
Integrative multi-omics and drug response profiling of childhood acute lymphoblastic leukemia cell lines.
Nat. Commun. 13:1691.1-1691.19(2022)

Cross-references
Cell line collections (Providers) JCRB; JCRB1332
Anatomy/cell type resources BTO; BTO:0004951
Chemistry resources ChEMBL-Cells; CHEMBL3307425
ChEMBL-Targets; CHEMBL614769
PubChem_Cell_line; CVCL_3039
Encyclopedic resources Wikidata; Q54907390
Gene expression databases GEO; GSM5137732
GEO; GSM5137763
Polymorphism and mutation databases Cosmic; 801717
Cosmic; 932760
Cosmic; 998694
Cosmic; 1037720
Proteomic databases PRIDE; PXD023662
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number23