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Cellosaurus LC-1/sq (CVCL_3008)

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Cell line name LC-1/sq
Synonyms LC-1 sq; LC-1-sq; LC-1Sq; LC-1sq; LC1/Sq; LC1-Sq; LC1-sq; LC1sq; Lc1sq; LC1SQ; Lung cancer-1/squamous; LC-1; LC1
Accession CVCL_3008
Resource Identification Initiative To cite this cell line use: LC-1/sq (RRID:CVCL_3008)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Japanese.
Doubling time: 64.6 hours (PubMed=1917142); ~75 hours (Note=Lot 11122004) (JCRB=JCRB0258).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; CRISPR screening.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (PubMed=9673367).
  • Mutation; HGNC; HGNC:17575; SPEN; Simple; p.Arg1475Ter (c.4423C>T); Zygosity=Heterozygous (Cosmic-CLP=1298223; DepMap=ACH-002156).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Met237Ile (c.711G>T); ClinVar=VCV000634770; Zygosity=Homozygous (PubMed=8263009; PubMed=10536175; PubMed=20557307; Cosmic-CLP=1298223; DepMap=ACH-002156).
HLA typing Source: PubMed=9023415
Class I
HLA-AA*11,24:02
HLA-BB*44:03:01
HLA-CC*12:03,16:01
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.33
Native American0
East Asian, North91.84
East Asian, South7.55
South Asian0.28
European, North0
European, South0
Disease Lung squamous cell carcinoma (NCIt: C3493)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_5480 (LC-1/sq-SF)CVCL_1372 (LC-1F)
Sex of cell Male
Age at sampling 69Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=1298223; JCRB=JCRB0258; RCB=RCB0455

Markers:
AmelogeninX
CSF1PO12
D5S81812,13
D7S82012
D13S31712,13
D16S5399
TH017,9
TPOX8,12
vWA17,18

Run an STR similarity search on this cell line
Publications

PubMed=1917142; DOI=10.1002/ijc.2910490322
Hiroshi Itoh, Hiroaki Kataoka, Hiroyuki Koita, Kazuki Nabeshima, Teruhiko Inoue, Kenji Kangawa, Masashi Koono;
Establishment of a new human cancer cell line secreting protease nexin-II/amyloid beta protein precursor derived from squamous-cell carcinoma of lung.
Int. J. Cancer 49:436-443(1991)

PubMed=8348978; DOI=10.1016/0014-5793(93)80946-R
Hiroaki Kataoka, Kohji Seguchi, Teruhiko Inoue, Masashi Koono;
Properties of alpha 1-antitrypsin secreted by human adenocarcinoma cell lines.
FEBS Lett. 328:291-295(1993)

PubMed=8263009; DOI=10.1007/BF01202192
Tatsuhiko Kashii, Yutaka Mizushima, Satoshi Monno, K. Nakagawa, M. Kobayashi;
Gene analysis of K-, H-ras, p53, and retinoblastoma susceptibility genes in human lung cancer cell lines by the polymerase chain reaction/single-strand conformation polymorphism method.
J. Cancer Res. Clin. Oncol. 120:143-148(1994)

PubMed=9023415; DOI=10.1006/cimm.1996.1062
Naoko Seki, Tomoaki Hoshino, Megumi Kikuchi, Akihiro Hayashi, Kyogo Itoh;
HLA-A locus-restricted and tumor-specific CTLs in tumor-infiltrating lymphocytes of patients with non-small cell lung cancer.
Cell. Immunol. 175:101-110(1997)

PubMed=9538136; DOI=10.3892/ijo.12.5.1103
Toshiyuki Takaki, Akio Hiraki, Akiko Uenaka, Shinya Gomi, Kyogo Itoh, Heiichiro Udono, Akira Shibuya, Takao Tsuji, Sadayoshi Sekiguchi, Eiichi Nakayama;
Variable expression on lung cancer cell lines of HLA-A2-binding MAGE-3 peptide recognized by cytotoxic T lymphocytes.
Int. J. Oncol. 12:1103-1109(1998)

PubMed=9673367
Takashi Fujishita, Yutaka Mizushima, Tatsuhiko Kashii, Masashi Kobayashi;
Coincidental alterations of p16INK4A/CDKN2 and other genes in human lung cancer cell lines.
Anticancer Res. 18:1537-1542(1998)

PubMed=10536175; DOI=10.3892/ijo.15.5.927
Takeshi Fujita, Masaharu Kiyama, Yoshio Tomizawa, Takashi Kohno, Jun Yokota;
Comprehensive analysis of p53 gene mutation characteristics in lung carcinoma with special reference to histological subtypes.
Int. J. Oncol. 15:927-934(1999)

PubMed=11005564; DOI=10.1038/sj.neo.7900094; PMCID=PMC1550293
Takashi Kohno, Takako Sato, Satoshi Takakura, Kimiko Takei, Kaoru Inoue, Michiho Nishioka, Jun Yokota;
Mutation and expression of the DCC gene in human lung cancer.
Neoplasia 2:300-305(2000)

PubMed=14581340
Sana Yokoi, Kohichiroh Yasui, Toshihiko Iizasa, Issei Imoto, Takehiko Fujisawa, Johji Inazawa;
TERC identified as a probable target within the 3q26 amplicon that is detected frequently in non-small cell lung cancers.
Clin. Cancer Res. 9:4705-4713(2003)

PubMed=15185009; DOI=10.1007/s00262-004-0533-9; PMCID=PMC11034254
Haruko Yamaji, Toshihiko Iizasa, Eitetsu Koh, Makoto Suzuki, Mizuto Otsuji, Hao Chang, Shinichiro Motohashi, Sana Yokoi, Kenzo Hiroshima, Masatoshi Tagawa, Toshinori Nakayama, Takehiko Fujisawa;
Correlation between interleukin 6 production and tumor proliferation in non-small cell lung cancer.
Cancer Immunol. Immunother. 53:786-792(2004)

PubMed=15746151; DOI=10.1093/hmg/ddi092
Hiroto Izumi, Jun Inoue, Sana Yokoi, Hiroshi Hosoda, Tatsuhiro Shibata, Makoto Sunamori, Setsuo Hirohashi, Johji Inazawa, Issei Imoto;
Frequent silencing of DBC1 is by genetic or epigenetic mechanisms in non-small cell lung cancers.
Hum. Mol. Genet. 14:997-1007(2005)

PubMed=19472407; DOI=10.1002/humu.21028; PMCID=PMC2900846
Raquel Blanco, Reika Iwakawa, Mo-Ying Tang, Takashi Kohno, Barbara Angulo, Ruben Pio, Luis M. Montuenga, John D. Minna, Jun Yokota, Montse Sanchez-Cespedes;
A gene-alteration profile of human lung cancer cell lines.
Hum. Mutat. 30:1199-1206(2009)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=20557307; DOI=10.1111/j.1349-7006.2010.01622.x; PMCID=PMC11158680
Reika Iwakawa, Takashi Kohno, Masatoshi Enari, Tohru Kiyono, Jun Yokota;
Prevalence of human papillomavirus 16/18/33 infection and p53 mutation in lung adenocarcinoma.
Cancer Sci. 101:1891-1896(2010)

PubMed=24002593; DOI=10.1038/bjc.2013.452; PMCID=PMC3776976
D. Wu, Yi Pang, Matthew D. Wilkerson, D. Wang, Peter S. Hammerman, Jun S. Liu;
Gene-expression data integration to squamous cell lung cancer subtypes reveals drug sensitivity.
Br. J. Cancer 109:1599-1608(2013)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=30971826; DOI=10.1038/s41586-019-1103-9
Fiona M. Behan, Francesco Iorio, Gabriele Picco, Emanuel Goncalves, Charlotte M. Beaver, Giorgia Migliardi, Rita Santos, Yanhua Rao, Francesco Sassi, Marika Pinnelli, Rizwan Ansari ...Show all 25 authors... , Sarah Harper, David Adam Jackson, Rebecca McRae, Rachel Pooley, Piers Wilkinson, Dieudonne J. van der Meer, David Dow, Carolyn A. Buser-Doepner, Andrea Bertotti, Livio Trusolino, Euan Alexander Stronach, Julio Saez-Rodriguez, Kosuke Yusa, Mathew J. Garnett; Show fewer authors
Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.
Nature 568:511-516(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

PubMed=38639832; DOI=10.1007/s13577-024-01055-0; PMCID=PMC11194210
Fumio Kasai, Makoto Fukushima, Yohei Miyagi, Yukio Nakamura;
Genetic diversity among the present Japanese population: evidence from genotyping of human cell lines established in Japan.
Hum. Cell 37:944-950(2024)

Cross-references
Cell line collections (Providers) JCRB; JCRB0258
RCB; RCB0455
Cell line databases/resources CLO; CLO_0037019
CLO; CLO_0050045
cancercelllines; CVCL_3008
Cell_Model_Passport; SIDM00300
CGH-DB; 188-1
CGH-DB; 9178-4
Cosmic-CLP; 1298223
DepMap; ACH-002156
LINCS_LDP; LCL-1586
Biological sample resources BioSample; SAMN03471667
CRISP screens repositories BioGRID_ORCS_Cell_line; 927
Chemistry resources GDSC; 1298223
PharmacoDB; LC1sq_828_2019
Encyclopedic resources Wikidata; Q54902121
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM784280
GEO; GSM827201
GEO; GSM1374618
GEO; GSM1670042
Polymorphism and mutation databases Cosmic; 713858
Cosmic; 801579
Cosmic; 844843
Cosmic; 876169
Cosmic; 889102
Cosmic; 917979
Cosmic; 929146
Cosmic; 932926
Cosmic; 1219072
Cosmic; 1239906
Cosmic; 2668326
IARC_TP53; 2382
Progenetix; CVCL_3008
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number38