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Cellosaurus DT40-PTPN6(-/-)-PTPN11(-/-) (CVCL_2G92)

[Text version]
Cell line name DT40-PTPN6(-/-)-PTPN11(-/-)
Synonyms SHP1^(-)/SHP2^(-) DT40; SHP-1/SHP-2-deficient DT40
Accession CVCL_2G92
Resource Identification Initiative To cite this cell line use: DT40-PTPN6(-/-)-PTPN11(-/-) (RRID:CVCL_2G92)
Comments Group: Bird cell line.
Knockout cell: Method=Targeted integration; PTPN6+PTPN11.
Transformant: NCBI_TaxID; 11864; Avian leukosis virus (ALV).
Cell type: B-cell; CL=CL_0000236.
Disease Chicken bursal lymphoma (NCIt: C134556)
Species of origin Gallus gallus (Chicken) (NCBI Taxonomy: 9031)
Breed/subspecies: Hy-Line SC.
Hierarchy Parent: CVCL_2G91 (DT40-PTPN6(-/-))
Sex of cell Female
Age at sampling 1D
Category Cancer cell line

PubMed=9547347; DOI=10.1084/jem.187.8.1355
Maeda A., Kurosaki M., Ono M., Takai T., Kurosaki T.
Requirement of SH2-containing protein tyrosine phosphatases SHP-1 and SHP-2 for paired immunoglobulin-like receptor B (PIR-B)-mediated inhibitory signal.
J. Exp. Med. 187:1355-1360(1998)

Cell line collections (Providers) RCB; RCB1501
Cell line databases/resources CLO; CLO_0051474
Encyclopedic resources Wikidata; Q54831511
Entry history
Entry creation22-Sep-2015
Last entry update29-Jun-2023
Version number9