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Cellosaurus AG04659 (CVCL_2B13)

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Cell line name AG04659
Synonyms AG_04659; AG4659; GRC#0219
Accession CVCL_2B13
Resource Identification Initiative To cite this cell line use: AG04659 (RRID:CVCL_2B13)
Comments Part of: Baltimore Longitudinal Study of Aging (BLSA) cell line collection.
Population: Caucasian.
Senescence: Senesces at 29 PDL (Coriell=AG04659).
Doubling time: 1.7 days (PubMed=12840040).
Omics: Transcriptomics; Microarray.
Derived from site: In situ; Arm, skin; UBERON=UBERON_0002427.
Cell type: Fibroblast of skin; CL=CL_0002620.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_2B43 ! AG05283
CVCL_2D83 ! AG11243
Sex of cell Male
Age at sampling 65Y
Category Finite cell line
Publications

PubMed=7307581; DOI=10.1159/000131624
Edward L. Schneider, Robert Monticone, James R. Smith, Karen I. Braunschweiger, Thomas W. Roberts;
Skin fibroblast cultures derived from members of the Baltimore longitudinal study: a new resource for studies of cellular aging.
Cytogenet. Cell Genet. 31:40-46(1981)

CLPUB00597
National Institute on Aging
1994 catalog of cell lines. NIA Aging Cell Repository.
(In misc. document) Institute for Medical Research (Camden, N.J.); pp.1-351; National Institutes of Health; Bethesda; USA (1994)

PubMed=12840040; DOI=10.1101/gr.1289803; PMCID=PMC403735
Mazen W. Karaman, Marlys L. Houck, Leona G. Chemnick, Shailender Nagpal, Daniel Chawannakul, Dominick Sudano, Brian L. Pike, Vincent V. Ho, Oliver A. Ryder, Joseph G. Hacia;
Comparative analysis of gene-expression patterns in human and African great ape cultured fibroblasts.
Genome Res. 13:1619-1630(2003)

PubMed=14662655; DOI=10.1093/hmg/ddh026
Sikandar G. Khan, Ahmet Metin, Engin Mevlut Gozukara, Hiroki Inui, Tala Shahlavi, Vanessa Muniz-Medina, Carl C. Baker, Takahiro Ueda, Juliet R. Aiken, Thomas D. Schneider, Kenneth H. Kraemer;
Two essential splice lariat branchpoint sequences in one intron in a xeroderma pigmentosum DNA repair gene: mutations result in reduced XPC mRNA levels that correlate with cancer risk.
Hum. Mol. Genet. 13:343-352(2004)

PubMed=16081512; DOI=10.1093/carcin/bgi204
Sikandar G. Khan, Kyu-Seon Oh, Tala Shahlavi, Takahiro Ueda, David B. Busch, Hiroki Inui, Steffen Emmert, Kyoko Imoto, Vanessa Muniz-Medina, Carl C. Baker, John Joseph DiGiovanna ...Show all 18 authors... , Deborah Schmidt, Arash Khadavi, Ahmet Metin, Engin Mevlut Gozukara, Hanoch Slor, Alain Sarasin, Kenneth H. Kraemer; Show fewer authors
Reduced XPC DNA repair gene mRNA levels in clinically normal parents of xeroderma pigmentosum patients.
Carcinogenesis 27:84-94(2006)

PubMed=18368133; DOI=10.1038/jid.2008.48; PMCID=PMC2562952
Hiroki Inui, Kyu-Seon Oh, Carine Nadem, Takahiro Ueda, Sikandar G. Khan, Ahmet Metin, Engin Mevlut Gozukara, Steffen Emmert, Hanoch Slor, David B. Busch, Carl C. Baker ...Show all 22 authors... , John Joseph DiGiovanna, Deborah Tamura, Cornelia S. Seitz, Alexei Gratchev, Wen-Hao Wu, Kee Yang Chung, Hye Jin Chung, Esther Azizi, Roger Woodgate, Thomas D. Schneider, Kenneth H. Kraemer; Show fewer authors
Xeroderma pigmentosum-variant patients from America, Europe, and Asia.
J. Invest. Dermatol. 128:2055-2068(2008)

Cross-references
Cell line collections (Providers) Coriell; AG04659
Cell line databases/resources CLO; CLO_0034920
Encyclopedic resources Wikidata; Q54610375
Gene expression databases GEO; GSM6348
Entry history
Entry creation22-Sep-2015
Last entry update10-Apr-2025
Version number15