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Cellosaurus J-111 (CVCL_2965)

[Text version]
Cell line name J-111
Synonyms J 111; J111; JIII; Oregon J-111
Accession CVCL_2965
Resource Identification Initiative To cite this cell line use: J-111 (RRID:CVCL_2965)
Comments Group: Space-flown cell line (cellonaut).
Problematic cell line: Contaminated. Shown to be a HeLa derivative (PubMed=4864103; PubMed=5641128; PubMed=566722; PubMed=1246601; PubMed=12592342; PubMed=20143388). Originally thought to originate from a 25 year old female patient with acute monocytic leukemia.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00009.
Population: African American.
Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
Anecdotal: Have been flown in space on the ISS to study motility and cytoskeletal structures (PubMed=21246756).
Miscellaneous: Formerly the CCRID database had an entry describing this cell line (3111C0002000000054). It was one of the sources for the STR profile of this entry.
Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
Disease Human papillomavirus-related endocervical adenocarcinoma (NCIt: C27677)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0030 (HeLa)
Sex of cell Female
Age at sampling 30Y6M
Category Cancer cell line
STR profile Source(s): CCRID; JCRB=IFO50005; JCRB=JCRB0073; PubMed=11416159

Markers:
AmelogeninX
CSF1PO9,10
D3S135815,18
D5S81811,12
D7S8208,12
D8S117912
D13S31712,13.3 (JCRB=IFO50005; JCRB=JCRB0073)
12,14 (CCRID)
D16S5399,10
D18S5116
D21S1127,28
FGA18,21
Penta D8,15
Penta E7,17
TH017
TPOX8,12
vWA16,18

Run an STR similarity search on this cell line
Web pages Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications

PubMed=13260360; DOI=10.1182/blood.V10.10.1010.1010
Edwin Eugene Osgood, John H. Brooke;
Continuous tissue culture of leukocytes from human leukemic bloods by application of gradient principles.
Blood 10:1010-1022(1955)

PubMed=13431913; DOI=10.3181/00379727-94-23044
George E. Foley, Alfred H. Handler;
Differentiation of normal and neoplastic cells maintained in tissue culture by implantation into normal hamsters.
Proc. Soc. Exp. Biol. Med. 94:661-664(1957)

PubMed=14185313; DOI=10.1126/science.146.3641.241
Cell Culture Collection Committee
Animal cell strains. The Cell Culture Collection Committee has assembled and certified 23 strains of animal cells.
Science 146:241-243(1964)

PubMed=4864103
Stanley Michael Gartler;
Genetic markers as tracers in cell culture.
Natl. Cancer Inst. Monogr. 26:167-195(1967)

PubMed=5641128; DOI=10.1038/217750a0
Stanley Michael Gartler;
Apparent Hela cell contamination of human heteroploid cell lines.
Nature 217:750-751(1968)

PubMed=4894370; DOI=10.1002/1097-0142(196908)24:2<211::AID-CNCR2820240202>3.0.CO;2-3
Chester Milton Southam, Joseph Holland Burchenal, Bayard Delafield Clarkson Sr., Adrienne Tanzi, Rosemary Mackey, Vivian McComb;
Heterotransplantability of human cell lines derived from leukemia and lymphomas into immunologically tolerant rats.
Cancer 24:211-222(1969)

DOI=10.1007/BF02618370
Cyril S. Stulberg, Lewis Lemon Coriell, Alexis John Kniazeff, John E. Shannon;
The animal cell culture collection.
In Vitro 5:1-16(1970)

PubMed=1246601; DOI=10.1126/science.1246601
Walter Anthony Nelson-Rees, Robert R. Flandermeyer;
HeLa cultures defined.
Science 191:96-98(1976)

PubMed=566722; DOI=10.1007/BF02616110
Kantharajapura Subbegowda Lavappa;
Survey of ATCC stocks of human cell lines for HeLa contamination.
In Vitro 14:469-475(1978)

PubMed=6988327; DOI=10.1007/BF02831503
Stephen James O'Brien, John E. Shannon, Mitchell H. Gail;
A molecular approach to the identification and individualization of human and animal cells in culture: isozyme and allozyme genetic signatures.
In Vitro 16:119-135(1980)

PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D
Li-Qun Jia, Motonobu Osada, Chikashi Ishioka, Makio Gamo, Shuntaro Ikawa, Takao Suzuki, Hideki Shimodaira, Tomohito Niitani, Toshio Kudo, Mitoshi Akiyama, Narimiti Kimura ...Show all 18 authors... , Mitsuyoshi Matsuo, Hiroshi Mizusawa, Noriho Tanaka, Hideki Koyama, Masayoshi Namba, Ryunosuke Kanamaru, Toshio Kuroki; Show fewer authors
Screening the p53 status of human cell lines using a yeast functional assay.
Mol. Carcinog. 19:243-253(1997)

PubMed=9510473; DOI=10.1111/j.1349-7006.1998.tb00476.x; PMCID=PMC5921588
Noriko Hosoya, Akira Hangaishi, Seishi Ogawa, Kiyoshi Miyagawa, Kinuko Mitani, Yoshio Yazaki, Hisamaru Hirai;
Frameshift mutations of the hMSH6 gene in human leukemia cell lines.
Jpn. J. Cancer Res. 89:33-39(1998)

PubMed=11416159; DOI=10.1073/pnas.121616198; PMCID=PMC35459
John R.W. Masters, Jim A. Thomson, Bernadette Daly-Burns, Yvonne A. Reid, Wilhelm Gerhard Dirks, Phil Packer, Lorraine H. Toji, Tadao Ohno, Hideyuki Tanabe, Colin Francis Arlett, Lloyd R. Kelland ...Show all 16 authors... , Maureen Harrison, Arvind K. Virmani, Timothy H. Ward, Karen L. Ayres, Paul G. Debenham; Show fewer authors
Short tandem repeat profiling provides an international reference standard for human cell lines.
Proc. Natl. Acad. Sci. U.S.A. 98:8012-8017(2001)

PubMed=12592342; DOI=10.1038/sj.leu.2402799
Hans Gunther Drexler, Wilhelm Gerhard Dirks, Yoshinobu Matsuo, Roderick A.F. MacLeod;
False leukemia-lymphoma cell lines: an update on over 500 cell lines.
Leukemia 17:416-426(2003)

PubMed=20143388; DOI=10.1002/ijc.25242
Amanda Capes-Davis, George Theodosopoulos, Isobel Atkin, Hans Gunther Drexler, Arihiro Kohara, Roderick A.F. MacLeod, John R.W. Masters, Yukio Nakamura, Yvonne A. Reid, Roger Robert Reddel, Robert Ian Freshney;
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

PubMed=21246756; DOI=10.1002/cm.20499
Maria Antonia Meloni, Grazia Galleri, Giuseppe Pani, Angela Saba, Proto Pippia, Marianne Cogoli-Greuter;
Space flight affects motility and cytoskeletal structures in human monocyte cell line J-111.
Cytoskeleton 68:125-137(2011)

Cross-references
Cell line collections (Providers) ATCC; CCL-24 - Discontinued
ECACC; 93120824
IZSLER; BS TCL 30
JCRB; IFO50005
JCRB; JCRB0073
Cell line databases/resources CLO; CLO_0006981
CLO; CLO_0007024
CLDB; cl2915
CLDB; cl2916
Biological sample resources BioSample; SAMN03151724
Encyclopedic resources Wikidata; Q54898403
Polymorphism and mutation databases Cosmic; 919124
Cosmic; 998751
Cosmic; 1037668
IARC_TP53; 21413
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number30