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Cellosaurus HEC-59 (CVCL_2930)

[Text version]
Cell line name HEC-59
Synonyms HEC59; Hec59
Accession CVCL_2930
Resource Identification Initiative To cite this cell line use: HEC-59 (RRID:CVCL_2930)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: MD Anderson Cell Lines Project.
Population: Japanese.
Doubling time: 24.3 hours (Note=At 152th passage) (DOI=10.5795/jjscc.26.433).
Microsatellite instability: Instable (MSI) (PubMed=31068700).
Omics: Deep exome analysis.
Omics: Deep quantitative proteome analysis.
Omics: Protein expression by reverse-phase protein arrays.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Endometrium; UBERON=UBERON_0001295.
Sequence variations
  • Mutation; HGNC; 7989; NRAS; Simple; p.Ala146Val (c.437C>T); Zygosity=Heterozygous (DepMap).
  • Mutation; HGNC; 9588; PTEN; Simple; p.Tyr46His (c.136T>C); ClinVar=VCV001701143; Zygosity=Heterozygous (PubMed=20944090; DepMap).
  • Mutation; HGNC; 9588; PTEN; Simple; p.Pro213Leufs (c.637_638insT) (c.637C>CT); Zygosity=Heterozygous (PubMed=20944090).
  • Mutation; HGNC; 9588; PTEN; Simple; p.Arg233Ter (c.697C>T); ClinVar=VCV000007813; Zygosity=Heterozygous (PubMed=20944090; DepMap).
  • Mutation; HGNC; 9588; PTEN; Simple; p.Lys267Argfs*9 (c.800delA) (p.Leu265fs, c.795delA); ClinVar=VCV000092828; Zygosity=Heterozygous (PubMed=20944090; DepMap).
  • Mutation; HGNC; 11998; TP53; Simple; p.Ser95Phe (c.284C>T); ClinVar=VCV001796813; Zygosity=Heterozygous (DepMap).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Heterozygous (PubMed=15053063; DepMap).
HLA typing Source: PubMed=26589293
Class I
HLA-AA*24:02,24:02
HLA-BB*40:06,40:06
HLA-CC*08:01,08:01
Class II
HLA-DQDQA1*02:01,02:01
HLA-DRDRB1*04:66,04:66
Genome ancestry Source: PubMed=30894373

Origin% genome
African1.33
Native American0.09
East Asian, North79.33
East Asian, South17.72
South Asian0.28
European, North0
European, South1.25
Disease Endometrial adenocarcinoma (NCIt: C7359)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): AddexBio; JCRB; PubMed=25877200

Markers:
AmelogeninX
CSF1PO9,10
D2S133815,16
D3S135813,14,16,17
D5S81810,11,12
D7S82010,11,14
D8S117912,15
D13S3179,10,11
D16S53911,12,13
D18S5112,13
D19S43312,13
D21S1129,32
FGA21,22,23
Penta D9,10,11
Penta E15,16
TH017,9.3
TPOX11 (PubMed=25877200)
11,14 (AddexBio; JCRB)
vWA17,20,22

Run an STR similarity search on this cell line
Web pages https://tcpaportal.org/mclp/
Publications

DOI=10.5795/jjscc.26.433
Morisawa T.
The results of primary culture of endometrial adenocarcinoma and characterization of its established cell line.
Nihon Rinsho Saibo Gakkai Zasshi 26:433-442(1987)

PubMed=2064198; DOI=10.1111/j.1749-6632.1991.tb37884.x
Kuramoto H., Nishida M., Morisawa T., Hamano M., Hata H., Kato Y., Ohno E., Iida T.
Establishment and characterization of human endometrial cancer cell lines.
Ann. N. Y. Acad. Sci. 622:402-421(1991)

PubMed=9000572
Hoang J.-M., Cottu P.H., Thuille B., Salmon R.J., Thomas G., Hamelin R.
BAT-26, an indicator of the replication error phenotype in colorectal cancers and cell lines.
Cancer Res. 57:300-303(1997)

PubMed=10381137; DOI=10.1016/s0304-3835(98)00270-5
Ohta H., Sakamoto H., Satoh K.
In vitro effects of gonadotropin-releasing hormone (GnRH) analogue on cancer cell sensitivity to cis-platinum.
Cancer Lett. 134:111-118(1998)

PubMed=12227503; DOI=10.1111/j.1749-0774.2002.tb00103.x
Kuramoto H., Hamano M., Imai M.
HEC-1 cells.
Hum. Cell 15:81-95(2002)

DOI=10.1007/978-4-431-53981-0_1
Kuramoto H., Hamano M., Imai M., Fujisawa T., Kamata Y., Arai T., Kawaguchi M.
HEC-1 cells: establishment of an in vitro experimental system in endometrial carcinoma.
(In) Cell and molecular biology of endometrial carcinoma; Kuramoto H., Nishida M. (eds.); pp.3-34; Springer; Tokyo (2003)

PubMed=15053063
Kamata Y., Watanabe J., Hata H., Hamano M., Kuramoto H.
Quantitative study on the correlation between p53 gene mutation and its expression in endometrial carcinoma cell lines.
Eur. J. Gynaecol. Oncol. 25:55-60(2004)

PubMed=20944090; DOI=10.1126/scitranslmed.3001538
Dedes K.J., Wetterskog D., Mendes-Pereira A.M., Natrajan R., Lambros M.B., Geyer F.C., Vatcheva R., Savage K., Mackay A., Lord C.J., Ashworth A., Reis-Filho J.S.
PTEN deficiency in endometrioid endometrial adenocarcinomas predicts sensitivity to PARP inhibitors.
Sci. Transl. Med. 2:53ra75.1-53ra75.8(2010)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=25877200; DOI=10.1038/nature14397
Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M., Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S., Neve R.M.
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5
Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P., Loewer M., Sahin U., Castle J.C.
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P., Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31978347; DOI=10.1016/j.cell.2019.12.023
Nusinow D.P., Szpyt J., Ghandi M., Rose C.M., McDonald E.R. III, Kalocsay M., Jane-Valbuena J., Gelfand E.T., Schweppe D.K., Jedrychowski M.P., Golji J., Porter D.A., Rejtar T., Wang Y.K., Kryukov G.V., Stegmeier F., Erickson B.K., Garraway L.A., Sellers W.R., Gygi S.P.
Quantitative proteomics of the Cancer Cell Line Encyclopedia.
Cell 180:387-402.e16(2020)

Cross-references
Cell line collections (Providers) AddexBio; C0026001/42
JCRB; JCRB1120
JCRB; NIHS0392 - Discontinued
Cell line databases/resources cancercelllines; CVCL_2930
Cell_Model_Passport; SIDM01617
DepMap; ACH-000994
Biological sample resources BioSample; SAMN03472458
BioSample; SAMN03470882
BioSample; SAMN10988108
CRISP screens repositories BioGRID_ORCS_Cell_line; 717
Chemistry resources PharmacoDB; HEC59_530_2019
Encyclopedic resources Wikidata; Q54882265
Gene expression databases ArrayExpress; E-MTAB-2770
GEO; GSM887074
GEO; GSM888144
Polymorphism and mutation databases Cosmic; 1070806
Cosmic; 1223492
Cosmic; 1576460
Cosmic; 1622901
Cosmic; 1696750
Cosmic; 2030472
IARC_TP53; 20591
LiGeA; CCLE_600
Progenetix; CVCL_2930
Entry history
Entry creation04-Apr-2012
Last entry update30-Jan-2024
Version number32