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Cellosaurus HEC-116 (CVCL_2924)

[Text version]
Cell line name HEC-116
Synonyms HEC116
Accession CVCL_2924
Resource Identification Initiative To cite this cell line use: HEC-116 (RRID:CVCL_2924)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: MD Anderson Cell Lines Project.
Population: Japanese.
Doubling time: 27.2 hours (PubMed=2064198).
Omics: Proteomics; Expression; Reverse-phase protein array.
Derived from site: In situ; Endometrium; UBERON=UBERON_0001295.
Sequence variations
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Arg173Cys (c.517C>T); ClinVar=VCV000189500; Zygosity=Unspecified (DepMap=ACH-001518).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Unspecified (PubMed=15053063).
Disease Endometrial adenocarcinoma (NCIt: C7359)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): DepMap=ACH-001518; JCRB=JCRB1124; PubMed=25877200

Markers:
AmelogeninX
CSF1PO10
D2S133820,21
D3S135817
D5S81811,12
D7S82010,12
D8S117914
D13S3178,11
D16S5399
D18S5117,25
D19S43314,16.2
D21S1129
FGA23,25
Penta D12,13
Penta E14,18
TH016,8
TPOX11
vWA20

Run an STR similarity search on this cell line
Web pages Info; MCLP; -; https://tcpaportal.org/mclp/
Publications

PubMed=2064198; DOI=10.1111/j.1749-6632.1991.tb37884.x
Hiroyuki Kuramoto, Masato Nishida, Takayuki Morisawa, Mieko Hamano, Hiroki Hata, Yoshiki Kato, Eiji Ohno, Tomohiro Iida;
Establishment and characterization of human endometrial cancer cell lines.
Ann. N. Y. Acad. Sci. 622:402-421(1991)

DOI=10.1007/978-4-431-53981-0_1
Hiroyuki Kuramoto, Mieko Hamano, Manami Imai, Takesi Fujisawa, Yuko Kamata, Tsutomu Arai, Miwa Kawaguchi;
HEC-1 cells: establishment of an in vitro experimental system in endometrial carcinoma.
(In book chapter) Cell and molecular biology of endometrial carcinoma; Kuramoto, Hiroyuki & Nishida, Masato (eds.); pp.3-34; Springer; Tokyo; Japan (2003)

PubMed=15053063
Yuko Kamata, Junichi Watanabe, Hiroki Hata, Mieko Hamano, Hiroyuki Kuramoto;
Quantitative study on the correlation between p53 gene mutation and its expression in endometrial carcinoma cell lines.
Eur. J. Gynaecol. Oncol. 25:55-60(2004)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076
Jun Li, Wei Zhao, Rehan Akbani, Wen-Bin Liu, Zhen-Lin Ju, Shi-Yun Ling, Christopher P. Vellano, Paul Roebuck, Qing-Hua Yu, A. Karina Eterovic, Lauren Averett Byers ...Show all 25 authors... , Michael A. Davies, Wan-Leng Deng, Y.N. Vashisht Gopal, Guo Chen, Erika Maria von Euw, Dennis Joseph Slamon, Dylan Conklin, John Victor Heymach, Adi F. Gazdar, John D. Minna, Jeffrey N. Myers, Yi-Ling Lu, Gordon B. Mills, Han Liang; Show fewer authors
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

Cross-references
Cell line collections (Providers) JCRB; JCRB1124
JCRB; NIHS0395 - Discontinued
Cell line databases/resources cancercelllines; CVCL_2924
DepMap; ACH-001518
Biological sample resources BioSample; SAMN03470936
Encyclopedic resources Wikidata; Q54882255
Polymorphism and mutation databases Cosmic; 1223495
Cosmic; 1696748
Cosmic; 2030467
IARC_TP53; 20592
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number26