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Cellosaurus HEC-108 (CVCL_2923)

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Cell line name HEC-108
Synonyms HEC108
Accession CVCL_2923
Resource Identification Initiative To cite this cell line use: HEC-108 (RRID:CVCL_2923)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: MD Anderson Cell Lines Project.
Population: Japanese.
Doubling time: 26.5 hours (Note=At 19th passage) (DOI=10.5795/jjscc.26.433); ~42 hours (Note=Lot 07072012) (JCRB=JCRB1123).
Microsatellite instability: Instable (MSI) (PubMed=31068700).
Omics: Deep exome analysis.
Omics: Deep quantitative proteome analysis.
Omics: Protein expression by reverse-phase protein arrays.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Endometrium; UBERON=UBERON_0001295.
Sequence variations
  • Mutation; HGNC; 11110; ARID1A; Simple; p.Arg1446Ter (c.4336C>T); Zygosity=Heterozygous (DepMap=ACH-000990).
  • Mutation; HGNC; 11998; TP53; Simple; p.Pro151His (c.452C>A); ClinVar=VCV000376639; Zygosity=Heterozygous (DepMap=ACH-000990).
HLA typing Source: PubMed=26589293
Class I
HLA-AA*24:20,26:01
HLA-BB*40:01,52:01
HLA-CC*12:02,15:02
Class II
HLA-DQDQA1*01:03,02:01
DQB1*03:02,03:02
HLA-DRDRB1*14:05,15:02
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0
East Asian, North78.21
East Asian, South21.79
South Asian0
European, North0
European, South0
Disease Endometrial adenocarcinoma (NCIt: C7359)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): JCRB=JCRB1123; PubMed=25877200

Markers:
AmelogeninX
CSF1PO11,12
D2S133816,17,19,20
D3S135815,16,17
D5S8186,12 (JCRB=JCRB1123)
12 (PubMed=25877200)
D7S8208,9,12
D8S117911,13
D13S3179,10,11,12,13 (PubMed=25877200)
9,10,11,13,14 (JCRB=JCRB1123)
D16S53911,12,13 (PubMed=25877200)
12,13 (JCRB=JCRB1123)
D18S5111,12,13
D19S43311.2,12.2,14.2,15.2,16.2
D21S1129,30,31
FGA22,23
Penta D8,9,10
Penta E15,19,20
TH018,9
TPOX11 (PubMed=25877200)
11,12 (JCRB=JCRB1123)
vWA15,16,17

Run an STR similarity search on this cell line
Web pages https://tcpaportal.org/mclp/
Publications

DOI=10.5795/jjscc.26.433
Morisawa T.
The results of primary culture of endometrial adenocarcinoma and characterization of its established cell line.
Nihon Rinsho Saibo Gakkai Zasshi 26:433-442(1987)

PubMed=2064198; DOI=10.1111/j.1749-6632.1991.tb37884.x
Kuramoto H., Nishida M., Morisawa T., Hamano M., Hata H., Kato Y., Ohno E., Iida T.
Establishment and characterization of human endometrial cancer cell lines.
Ann. N. Y. Acad. Sci. 622:402-421(1991)

PubMed=8847459
Okamura N., Mori Y., Endo T., Ito E., Kudo R.
Experimental studies on the cell adhesion molecule E-cadherin and in vitro invasion of endometrial carcinoma cell lines.
Nihon Sanka Fujinka Gakkai Zasshi 48:335-342(1996)

DOI=10.1007/978-4-431-53981-0_1
Kuramoto H., Hamano M., Imai M., Fujisawa T., Kamata Y., Arai T., Kawaguchi M.
HEC-1 cells: establishment of an in vitro experimental system in endometrial carcinoma.
(In book chapter) Cell and molecular biology of endometrial carcinoma; Kuramoto H., Nishida M. (eds.); pp.3-34; Springer; Tokyo; Japan (2003)

PubMed=12893190; DOI=10.1016/S0090-8258(03)00335-4
Tanaka R., Saito T., Ashihara K., Nishimura M., Mizumoto H., Kudo R.
Three-dimensional coculture of endometrial cancer cells and fibroblasts in human placenta derived collagen sponges and expression matrix metalloproteinases in these cells.
Gynecol. Oncol. 90:297-304(2003)

PubMed=15053063
Kamata Y., Watanabe J., Hata H., Hamano M., Kuramoto H.
Quantitative study on the correlation between p53 gene mutation and its expression in endometrial carcinoma cell lines.
Eur. J. Gynaecol. Oncol. 25:55-60(2004)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=25877200; DOI=10.1038/nature14397
Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M., Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S., Neve R.M.
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P., Loewer M., Sahin U., Castle J.C.
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076
Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P., Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. 3rd, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31978347; DOI=10.1016/j.cell.2019.12.023; PMCID=PMC7339254
Nusinow D.P., Szpyt J., Ghandi M., Rose C.M., McDonald E.R. 3rd, Kalocsay M., Jane-Valbuena J., Gelfand E.T., Schweppe D.K., Jedrychowski M.P., Golji J., Porter D.A., Rejtar T., Wang Y.K., Kryukov G.V., Stegmeier F., Erickson B.K., Garraway L.A., Sellers W.R., Gygi S.P.
Quantitative proteomics of the Cancer Cell Line Encyclopedia.
Cell 180:387-402.e16(2020)

Cross-references
Cell line collections (Providers) JCRB; JCRB1123
JCRB; NIHS0394 - Discontinued
Cell line databases/resources CLO; CLO_0037286
cancercelllines; CVCL_2923
Cell_Model_Passport; SIDM01608
DepMap; ACH-000990
Biological sample resources BioSample; SAMN03470971
BioSample; SAMN03472459
BioSample; SAMN10987841
Chemistry resources PharmacoDB; HEC108_525_2019
Encyclopedic resources Wikidata; Q54882254
Gene expression databases ArrayExpress; E-MTAB-2770
GEO; GSM887067
GEO; GSM888137
Polymorphism and mutation databases Cosmic; 1223494
Cosmic; 1241342
Cosmic; 1696755
Cosmic; 2030466
IARC_TP53; 21065
IARC_TP53; 30205
LiGeA; CCLE_091
Progenetix; CVCL_2923
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number29