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Cellosaurus delta-47 (CVCL_2887)

[Text version]
Cell line name delta-47
Synonyms Delta-47; DELTA-47; Delta 47; DELTA 47; Delta47; DELTA47
Accession CVCL_2887
Resource Identification Initiative To cite this cell line use: delta-47 (RRID:CVCL_2887)
Comments Population: Japanese.
Characteristics: Produces IgD lambda.
Doubling time: 40 hours (PubMed=1329502).
Omics: Transcriptomics; RNAseq.
Omics: Variations; Array-based CGH.
Derived from site: In situ; Ascites; UBERON=UBERON_0007795.
Cell type: Plasma cell; CL=CL_0000786.
Sequence variations
Disease Plasma cell myeloma (NCIt: C3242)
Multiple myeloma (ORDO: Orphanet_29073)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 73Y
Category Cancer cell line
STR profile Source(s): JCRB=JCRB1344

Markers:
AmelogeninX
CSF1PO12
D5S81810,12
D7S82010
D13S3178
D16S5399,11
TH019
TPOX8,10
vWA14,20

Run an STR similarity search on this cell line
Web pages Info; Keats Lab; -; https://www.keatslab.org/myeloma-cell-lines
Publications

PubMed=1329502; DOI=10.1002/ajh.2830410314
Kazuyoshi Ishii, Kenji Yamato, Ichiro Kubonishi, Hirokuni Taguchi, Yuji Ohtsuki, Isao Miyoshi;
IgD myeloma presenting as a testicular tumor: establishment and characterization of an IgD-secreting myeloma cell line.
Am. J. Hematol. 41:218-224(1992)

PubMed=8943038; DOI=10.1073/pnas.93.24.13931; PMCID=PMC19472
Peter Leif Bergsagel, Marta Chesi, Elena Nardini, Leslie A. Brents, Suzanne Lee Kirby, Walter Michael Kuehl;
Promiscuous translocations into immunoglobulin heavy chain switch regions in multiple myeloma.
Proc. Natl. Acad. Sci. U.S.A. 93:13931-13936(1996)

DOI=10.1007/0-306-46877-8_4
Helena Jernberg-Wiklund, Kenneth Nilsson;
Multiple myeloma cell lines.
(In book chapter) Human cell culture. Vol. 3. Cancer cell lines part 3; Masters, John R.W. & Palsson, Bernhard Orn (eds.); pp.81-155; Kluwer Academic Publishers; New York; USA (2000)

PubMed=10936422; DOI=10.1016/S0145-2126(99)00195-2
Hans Gunther Drexler, Yoshinobu Matsuo;
Malignant hematopoietic cell lines: in vitro models for the study of multiple myeloma and plasma cell leukemia.
Leuk. Res. 24:681-703(2000)

DOI=10.1016/B978-0-12-221970-2.50457-5
Hans Gunther Drexler;
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=11157491; DOI=10.1182/blood.V97.3.729
Marta Chesi, Leslie A. Brents, Sarah A. Ely, Carlos Bais, Davide F. Robbiani, Enrique A. Mesri, Walter Michael Kuehl, Peter Leif Bergsagel;
Activated fibroblast growth factor receptor 3 is an oncogene that contributes to tumor progression in multiple myeloma.
Blood 97:729-736(2001)

PubMed=17692805; DOI=10.1016/j.ccr.2007.07.003; PMCID=PMC2083698
Jonathan J. Keats, Rafael Fonseca, Marta Chesi, Roelandt Schop, Angela Baker, Wee-Joo Chng, Scott Van Wier, Rodger Tiedemann, Chang-Xin Shi, Michael Sebag, Esteban Braggio ...Show all 30 authors... , Travis Henry, Yuan-Xiao Zhu, Homer Fogle, Tammy L. Price-Troska, Gregory J. Ahmann, Catherine Mancini, Leslie A. Brents, Shaji K. Kumar, Philip Robert Greipp, Angela Dispenzieri, Barb Bryant, George Mulligan, Laurakay Bruhn, Michael T. Barrett, Riccardo Valdez, Jeffrey M. Trent, A. Keith Stewart, John D. Carpten, Peter Leif Bergsagel; Show fewer authors
Promiscuous mutations activate the noncanonical NF-kappaB pathway in multiple myeloma.
Cancer Cell 12:131-144(2007)

PubMed=18647998; DOI=10.1093/jncimonographs/lgn011; PMCID=PMC2737184
Amel Dib, Ana Gabrea, Oleg K. Glebov, Peter Leif Bergsagel, Walter Michael Kuehl;
Characterization of MYC translocations in multiple myeloma cell lines.
J. Natl. Cancer Inst. Monogr. 39:25-31(2008)

CLPUB00604
Sharon Chow;
Targeted capture and sequencing of immunoglobulin rearrangements in multiple myeloma to enable detection of minimal residual disease.
Thesis MSc (2017); University of Toronto; Toronto; Canada

PubMed=32123307; DOI=10.1038/s41375-020-0785-1; PMCID=PMC7483300
Vishesh Sarin, Katharine Yu, Ian D. Ferguson, Olivia Gugliemini, Matthew A. Nix, Byron Hann, Marina Sirota, Arun P. Wiita;
Evaluating the efficacy of multiple myeloma cell lines as models for patient tumors via transcriptomic correlation analysis.
Leukemia 34:2754-2765(2020)

Cross-references
Cell line collections (Providers) JCRB; JCRB1344
JCRB; NIHS0543 - Discontinued
Cell line databases/resources SKY/M-FISH/CGH; 2517
Encyclopedic resources Wikidata; Q54830967
Polymorphism and mutation databases Cosmic; 720783
Cosmic; 760400
Cosmic; 2081378
Cosmic; 2302420
Cosmic; 2367274
Cosmic; 2391802
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number23