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Cellosaurus AZ-521 (CVCL_2862)

[Text version]
Cell line name AZ-521
Synonyms AZ 521; AZ521
Accession CVCL_2862
Resource Identification Initiative To cite this cell line use: AZ-521 (RRID:CVCL_2862)
Comments Problematic cell line: Contaminated. Shown to be a Hutu 80 derivative (see JCRB web site).
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: JFCR45 cancer cell line panel.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00369.
Doubling time: ~30 hours (Note=Lot 11162006) (JCRB=JCRB0061).
Omics: Transcriptomics; Microarray.
Omics: Variations; Array-based CGH.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Small intestine, duodenum; UBERON=UBERON_0002114.
Sequence variations
  • Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Ser37Phe (c.110C>T); ClinVar=VCV000017586; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; None_reported; -; Zygosity=- (PubMed=1370612).
Genome ancestry Source: PubMed=30894373

Origin% genome
African78.39
Native American0
East Asian, North1.7
East Asian, South0
South Asian0.23
European, North10.56
European, South9.12
Disease Duodenal adenocarcinoma (NCIt: C7889)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1301 (HuTu 80)
Children:
CVCL_9480 (AZ-H3c)CVCL_9479 (AZ-H6c)
Sex of cell Male
Age at sampling 53Y
Category Cancer cell line
STR profile Source(s): JCRB=JCRB0061; RCB=RCB2087; TKG=TKG 0185

Markers:
AmelogeninX,Y
CSF1PO11,13
D5S81812,13
D7S8209,11
D13S3178,11
D16S53910,11
TH017
TPOX9,11
vWA16,18

Run an STR similarity search on this cell line
Web pages Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Info; RCB; -; https://cell.brc.riken.jp/en/announcement/az521
Publications

PubMed=1370612; DOI=10.1016/S0006-291X(05)80133-0
Takashi Matozaki, Choitsu Sakamoto, Kohei Matsuda, Toshiya Suzuki, Yoshitaka Konda, Osamu Nakano, Ken Wada, Tohru Uchida, Hogara Nishisaki, Munehiko Nagao, Masato Kasuga;
Missense mutations and a deletion of the p53 gene in human gastric cancer.
Biochem. Biophys. Res. Commun. 182:215-223(1992)

PubMed=15723654; DOI=10.1111/j.1349-7006.2005.00016.x; PMCID=PMC11160020
Hisashi Takada, Issei Imoto, Hitoshi Tsuda, Itaru Sonoda, Takashi Ichikura, Hidetaka Mochizuki, Takeshi Okanoue, Johji Inazawa;
Screening of DNA copy-number aberrations in gastric cancer cell lines by array-based comparative genomic hybridization.
Cancer Sci. 96:100-110(2005)

PubMed=15767549; DOI=10.1158/1535-7163.MCT-04-0234
Noriyuki Nakatsu, Yoko Yoshida, Kanami Yamazaki, Tomoki Nakamura, Shingo Dan, Yasuhisa Fukui, Takao Yamori;
Chemosensitivity profile of cancer cell lines and identification of genes determining chemosensitivity by an integrated bioinformatical approach using cDNA arrays.
Mol. Cancer Ther. 4:399-412(2005)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Jordi Ginesta Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan, Adam A. Margolin, Sungjoon Kim, Christopher J. Wilson, Joseph Lehar, Gregory V. Kryukov, Dmitriy Sonkin, Anupama Reddy ...Show all 61 authors... , Manway Liu, Lauren Murray, Michael F. Berger, John E. Monahan, Paula Morais, Jodi Meltzer, Adam Korejwa, Judit Jane-Valbuena, Felipa A. Mapa, Joseph Thibault, Eva Bric-Furlong, Pichai Raman, Aaron Shipway, Ingo H. Engels, Jill Cheng, Guo-Ying K. Yu, Jian-Jun Yu, Peter Aspesi Jr., Melanie de Silva, Kalpana Jagtap, Michael D. Jones, Li Wang, Charles Hatton, Emanuele Palescandolo, Supriya Gupta, Scott Mahan, Carrie Sougnez, Robert C. Onofrio, Ted Liefeld, Laura E. MacConaill, Wendy Winckler, Michael Reich, Nan-Xin Li, Jill P. Mesirov, Stacey B. Gabriel, Gad Getz, Kristin Ardlie, Vivien Chan, Vic E. Myer, Barbara L. Weber, Jeff Porter, Markus Warmuth, Peter Finan, Jennifer L. Harris, Matthew Langer Meyerson, Todd Robert Golub, Michael P. Morrissey, William Raj Sellers, Robert Schlegel, Levi Alexander Garraway; Show fewer authors
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=25343454; DOI=10.1371/journal.pone.0111146; PMCID=PMC4208810
Meng-Ling Choong, Shan-Ho Tan, Tuan-Zea Tan, Sravanthy Manesh, Anna Ngo, Jacklyn W.-Y. Yong, Henry He Yang, May Ann Lee;
Molecular integrative clustering of Asian gastric cell lines revealed two distinct chemosensitivity clusters.
PLoS ONE 9:e111146.1-e111146.9(2014)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections (Providers) JCRB; JCRB0061
RCB; RCB2087 - Discontinued
TKG; TKG 0185
Cell line databases/resources CLO; CLO_0037137
CLO; CLO_0050792
cancercelllines; CVCL_2862
Cell_Model_Passport; SIDM01934
CGH-DB; 136-1
DepMap; ACH-001015
LINCS_LDP; LCL-1533
Biological sample resources BioSample; SAMN03151798
Chemistry resources ChEMBL-Cells; CHEMBL3307904
ChEMBL-Targets; CHEMBL614274
PharmacoDB; AZ521_72_2019
PubChem_Cell_line; CVCL_2862
Encyclopedic resources Wikidata; Q54752018
Experimental variables resources EFO; EFO_0002814
Gene expression databases FANTOM5_SSTAR; 10549-107H9
GEO; GSM552355
GEO; GSM562393
GEO; GSM827401
GEO; GSM843443
GEO; GSM886872
GEO; GSM887937
GEO; GSM1374397
Polymorphism and mutation databases Cosmic; 877047
Cosmic; 889108
Cosmic; 918495
Cosmic; 1066228
Cosmic; 1077281
Cosmic; 1187267
Cosmic; 1482080
Cosmic; 1518246
Cosmic; 2484969
IARC_TP53; 21179
Progenetix; CVCL_2862
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number38