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Cellosaurus 3A(tPA-30-1) (CVCL_2820)

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Cell line name 3A(tPA-30-1)
Synonyms TPA30-1; TPA 30-1; tPA30-1
Accession CVCL_2820
Resource Identification Initiative To cite this cell line use: 3A(tPA-30-1) (RRID:CVCL_2820)
Comments Characteristics: Expresses the transformed phenotype at the permissive temperature (33 Celsius) and the non-transformed phenotype at the restrictive temperature (40 Celsius).
Senescence: Has a limited life expectancy of 15 to 18 passages before entering the crisis stage (ATCC=CRL-1583).
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) (Note=ts30).
Derived from site: In situ; Placenta; UBERON=UBERON_0001987.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_2287 (3A sub E)
Originate from same individual CVCL_H646 ! TPA30-6
CVCL_H645 ! TPWT-2
Sex of cell Female
Category Transformed cell line
STR profile Source(s): ATCC=CRL-1583

Markers:
AmelogeninX
CSF1PO10,12
D2S133820,22
D3S135814,15
D5S81811,13
D7S82010
D8S117913,14
D13S31711
D16S5399,12
D18S5112,20
D19S43314,16.2
D21S1128,29
FGA21,25
Penta D8,9
Penta E7,14
TH019,9.3
TPOX8,11
vWA16,17

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Publications

PubMed=206898; DOI=10.1073/pnas.75.3.1409; PMCID=PMC411481
Janice Yang Chou;
Human placental cells transformed by tsA mutants of simian virus 40: a model system for the study of placental functions.
Proc. Natl. Acad. Sci. U.S.A. 75:1409-1413(1978)

PubMed=3493529; DOI=10.1126/science.3493529
Gordon G. Wong, Patricia A. Temple, Anne C. Leary, JoAnn S. Witek-Giannotti, Yu-Chung Yang, Agnes Brennan, Margaret Chung, Patricia Murtha, Ronald Kriz, Randal J. Kaufman, Catherine Rose Ferenz ...Show all 21 authors... , Barbara S. Sibley, Katherine J. Turner, Rodney M. Hewick, Steven C. Clark, Nobuya Yanai, Hajime Yokota, Muneo Yamada, Minoru Saito, Kazuo Motoyoshi, Fumimaro Takaku; Show fewer authors
Human CSF-1: molecular cloning and expression of 4-kb cDNA encoding the human urinary protein.
Science 235:1504-1508(1987)

PubMed=33043158; DOI=10.1016/j.heliyon.2020.e04759; PMCID=PMC7536373
Aiwa Ono, Paula A. Benny, Margaret Griffith, Christian Litton, Men-Jean Lee;
Appropriate citation of placenta cell lines 3A(tPA-30-1) and 3A-sub E [post crisis of 3A(tPA-30-1)] in medical literature.
Heliyon 6:e04759.1-e04759.9(2020)

Cross-references
Cell line collections (Providers) ATCC; CRL-1583
ECACC; 96020926
Cell line databases/resources CLO; CLO_0001325
Biological sample resources BioSample; SAMN03471399
Encyclopedic resources Wikidata; Q54585261
Experimental variables resources EFO; EFO_0022454
Entry history
Entry creation04-Apr-2012
Last entry update10-Sep-2024
Version number17