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Cellosaurus MOLT-4F (CVCL_2792)

[Text version]
Cell line name MOLT-4F
Synonyms MOLT-4f; Molt-4F; MOLT 4F; Molt/4F; MOLT4F; MOLT4f; MOLT-4-F
Accession CVCL_2792
Resource Identification Initiative To cite this cell line use: MOLT-4F (RRID:CVCL_2792)
Comments Population: Caucasian.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Leu1600Pro (c.4799T>C); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Pro2514Argfs*4 (c.7541_7542delCT); ClinVar=VCV000581973; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gly12Cys (c.34G>T); ClinVar=VCV000040468; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Lys267Argfs*9 (c.800delA) (p.Leu265fs, c.795delA); ClinVar=VCV000092828; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11389; STK11; Simple; p.Gln214Ter (c.640C>T); ClinVar=VCV000428759; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg306Ter (c.916C>T); ClinVar=VCV000142144; Zygosity=Heterozygous (from parent cell line).
Disease Adult T acute lymphoblastic leukemia (NCIt: C9142)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0013 (MOLT-4)
Sex of cell Male
Age at sampling 19Y
Category Cancer cell line
STR profile Source(s): RCB=RCB1936; TKG=TKG 0229

Markers:
AmelogeninX,Y
CSF1PO11,12
D5S81811,12,13 (RCB=RCB1936)
12,13 (TKG=TKG 0229)
D7S8207,8,10 (RCB=RCB1936)
7,8,10,11 (TKG=TKG 0229)
D13S31712,13
D16S53911,12,13
TH016,8
TPOX8
vWA17,18 (TKG=TKG 0229)
17,18,19 (RCB=RCB1936)

Run an STR similarity search on this cell line
Publications

PubMed=62390; DOI=10.1111/j.1365-3083.1976.tb03029.x
William J. Yount, Peter D. Utsinger, Lindsey M. Hutt, Philip D. Buchanan, Joseph H. Korn, C. Randall Fuller, Marshall J. Logue, Joseph S. Pagano;
Subpopulations of human lymphoblastoid cell lines. Correlation with the expression of surface receptors and content of Epstein-Barr virus genome.
Scand. J. Immunol. 5:795-810(1976)

PubMed=6600440; DOI=10.1007/BF02617996
Christel H. Uittenbogaart, Yael Cantor, John L. Fahey;
Growth of human malignant lymphoid cell lines in serum-free medium.
In Vitro 19:67-72(1983)

PubMed=3518877; DOI=10.3109/07357908609038260
Jorgen Fogh;
Human tumor lines for cancer research.
Cancer Invest. 4:157-184(1986)

PubMed=3495441; DOI=10.1002/eji.1830170503
Susan Kanowith-Klein, Andrew Saxon, Christel H. Uittenbogaart;
Constitutive production of B cell differentiation factor-like activity by human T and B cell lines.
Eur. J. Immunol. 17:593-598(1987)

PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D
Li-Qun Jia, Motonobu Osada, Chikashi Ishioka, Makio Gamo, Shuntaro Ikawa, Takao Suzuki, Hideki Shimodaira, Tomohito Niitani, Toshio Kudo, Mitoshi Akiyama, Narimiti Kimura ...Show all 18 authors... , Mitsuyoshi Matsuo, Hiroshi Mizusawa, Noriho Tanaka, Hideki Koyama, Masayoshi Namba, Ryunosuke Kanamaru, Toshio Kuroki; Show fewer authors
Screening the p53 status of human cell lines using a yeast functional assay.
Mol. Carcinog. 19:243-253(1997)

PubMed=9738977; DOI=10.1111/j.1349-7006.1998.tb03275.x; PMCID=PMC5921886
Jun Takizawa, Ritsuro Suzuki, Hiroyuki Kuroda, Atae Utsunomiya, Yoshitoyo Kagami, Tatsuroh Joh, Yoshifusa Aizawa, Ryuzo Ueda, Masao Seto;
Expression of the TCL1 gene at 14q32 in B-cell malignancies but not in adult T-cell leukemia.
Jpn. J. Cancer Res. 89:712-718(1998)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=20519628; DOI=10.1182/blood-2009-09-244673
Kinuko Hirose, Takeshi Inukai, Jiro Kikuchi, Yusuke Furukawa, Tomokatsu Ikawa, Hiroshi Kawamoto, S. Helen Oram, Berthold Gottgens, Nobutaka Kiyokawa, Yoshitaka Miyagawa, Hajime Okita ...Show all 22 authors... , Koshi Akahane, Xiao-Chun Zhang, Itaru Kuroda, Hiroko Honna, Keiko Kagami, Kumiko Goi, Hidemitsu Kurosawa, Alfred Thomas Look, Hirotaka Matsui, Toshiya Inaba, Kanji Sugita; Show fewer authors
Aberrant induction of LMO2 by the E2A-HLF chimeric transcription factor and its implication in leukemogenesis of B-precursor ALL with t(17;19).
Blood 116:962-970(2010)

Cross-references
Cell line collections (Providers) JCRB; JCRB0021
RCB; RCB1936
TKG; TKG 0229
Cell line databases/resources CLO; CLO_0050994
cancercelllines; CVCL_2792
LINCS_LDP; LCL-1031
Biological sample resources BioSample; SAMN03472036
Chemistry resources ChEMBL-Cells; CHEMBL3307263
ChEMBL-Targets; CHEMBL613515
PubChem_Cell_line; CVCL_2792
Encyclopedic resources Wikidata; Q54906370
Gene expression databases GEO; GSM827231
Polymorphism and mutation databases Progenetix; CVCL_2792
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number32