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Cellosaurus HO-1-u-1 (CVCL_2784)

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Cell line name HO-1-u-1
Synonyms HO-1-U-1; Ho-1-u-1; HO1-U-1; HO1-U1; Ho-1U1; HO1U1; HO1u1; Ho1u1; Ueda-1
Accession CVCL_2784
Resource Identification Initiative To cite this cell line use: HO-1-u-1 (RRID:CVCL_2784)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Japanese.
Characteristics: Suitable for in vitro sublingual drug delivery screening involving passive diffusion (PubMed=17079100; PubMed=19071203).
Doubling time: ~23 hours (DOI=10.5794/jjoms.31.1347).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; CRISPR screening.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Variations; SNP array analysis.
Misspelling: HO1-UI; Cosmic=2546834.
Derived from site: In situ; Salivary gland, sublingual gland; UBERON=UBERON_0001832.
Genome ancestry Source: PubMed=30894373

Origin% genome
African1.54
Native American0
East Asian, North76.45
East Asian, South19.98
South Asian0.41
European, North1.61
European, South0
Disease Floor of mouth squamous cell carcinoma (NCIt: C4041)
Squamous cell carcinoma of the oral cavity (ORDO: Orphanet_502363)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 72Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=753561; JCRB=JCRB0828; RCB=RCB2102; TKG=TKG 0455

Markers:
AmelogeninX,Y
CSF1PO10
D5S81810
D7S8209,10
D13S3179
D16S53912
TH019
TPOX10
vWA17,19

Run an STR similarity search on this cell line
Publications

DOI=10.5794/jjoms.31.1347
Shinobu Miyauchi, Takamasa Moroyama, Tomoji Sakamoto, Tetsuji Okamoto, Kazuaki Takada;
Establishment of human tumor cell line (Ueda-1) derived from squamous cell carcinoma of the floor of the mouth.
Nihon Koku Geka Gakkai Zasshi 31:1347-1351(1985)

PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D
Li-Qun Jia, Motonobu Osada, Chikashi Ishioka, Makio Gamo, Shuntaro Ikawa, Takao Suzuki, Hideki Shimodaira, Tomohito Niitani, Toshio Kudo, Mitoshi Akiyama, Narimiti Kimura ...Show all 18 authors... , Mitsuyoshi Matsuo, Hiroshi Mizusawa, Noriho Tanaka, Hideki Koyama, Masayoshi Namba, Ryunosuke Kanamaru, Toshio Kuroki; Show fewer authors
Screening the p53 status of human cell lines using a yeast functional assay.
Mol. Carcinog. 19:243-253(1997)

PubMed=12738951; DOI=10.1067/moe.2003.36
Masaru Sugiyama, Ujjal K. Bhawal, Tamiko Dohmen, Shigehiro Ono, Miwa Miyauchi, Takenori Ishikawa;
Detection of human papillomavirus-16 and HPV-18 DNA in normal, dysplastic, and malignant oral epithelium.
Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 95:594-600(2003)

PubMed=17079100; DOI=10.1016/j.ijpharm.2006.10.012
Yan-Feng Wang, Zhong Zuo, Kenneth Ka-Ho Lee, Moses S.-S. Chow;
Evaluation of HO-1-u-1 cell line as an in vitro model for sublingual drug delivery involving passive diffusion -- initial validation studies.
Int. J. Pharm. 334:27-34(2007)

PubMed=17325662; DOI=10.1038/sj.onc.1210330
K. Nakaya, Hidehisa D. Yamagata, Norimasa Arita, Koh-ichi Nakashiro, Masato Nose, Tetsuro Miki, Hiroyuki Hamakawa;
Identification of homozygous deletions of tumor suppressor gene FAT in oral cancer using CGH-array.
Oncogene 26:5300-5308(2007)

PubMed=19071203; DOI=10.1016/j.ijpharm.2008.11.010
Yan-Feng Wang, Zhong Zuo, Moses S.-S. Chow;
HO-1-u-1 model for screening sublingual drug delivery -- influence of pH, osmolarity and permeation enhancer.
Int. J. Pharm. 370:68-74(2009)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=25448555; DOI=10.1016/j.ijpharm.2014.11.040
Gaelle Vacher, Emmanuelle Sublet, Robert Gurny, Gerrit Borchard;
Establishment and first characterization of a sublingual epithelial and immune cell co-culture model.
Int. J. Pharm. 482:61-67(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=30971826; DOI=10.1038/s41586-019-1103-9
Fiona M. Behan, Francesco Iorio, Gabriele Picco, Emanuel Goncalves, Charlotte M. Beaver, Giorgia Migliardi, Rita Santos, Yanhua Rao, Francesco Sassi, Marika Pinnelli, Rizwan Ansari ...Show all 25 authors... , Sarah Harper, David Adam Jackson, Rebecca McRae, Rachel Pooley, Piers Wilkinson, Dieudonne J. van der Meer, David Dow, Carolyn A. Buser-Doepner, Andrea Bertotti, Livio Trusolino, Euan Alexander Stronach, Julio Saez-Rodriguez, Kosuke Yusa, Mathew J. Garnett; Show fewer authors
Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.
Nature 568:511-516(2019)

PubMed=32990596; DOI=10.7554/eLife.57761; PMCID=PMC7591259
Annie Wai-Yeeng Chai, Pei-San Yee, Stacey Price, Shi-Mun Yee, Hui-Mei Lee, Vivian K.H. Tiong, Emanuel Goncalves, Fiona M. Behan, Jessica Bateson, James G.R. Gilbert, Aik-Choon Tan ...Show all 14 authors... , Ultan McDermott, Mathew J. Garnett, Sok-Ching Cheong; Show fewer authors
Genome-wide CRISPR screens of oral squamous cell carcinoma reveal fitness genes in the Hippo pathway.
eLife 9:e57761.1-e57761.34(2020)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) JCRB; JCRB0828
RCB; RCB2102
TKG; TKG 0455
Cell line databases/resources CLO; CLO_0051384
cancercelllines; CVCL_2784
Cell_Model_Passport; SIDM00591
Cosmic-CLP; 753561
DepMap; ACH-002045
LINCS_LDP; LCL-1202
Anatomy/cell type resources BTO; BTO_0005948
Biological sample resources BioSample; SAMN01821683
BioSample; SAMN03472521
CRISP screens repositories BioGRID_ORCS_Cell_line; 864
Chemistry resources GDSC; 753561
PharmacoDB; HO1u1_560_2019
Encyclopedic resources Wikidata; Q54890083
Gene expression databases ArrayExpress; E-MTAB-3610
FANTOM5_SSTAR; 10550-107I1
GEO; GSM827216
GEO; GSM850381
GEO; GSM1669889
Polymorphism and mutation databases Cosmic; 753561
Cosmic; 1118792
Cosmic; 1120707
Cosmic; 1530742
Cosmic; 1571800
Cosmic; 1995441
Cosmic; 2266788
Cosmic; 2546834
Progenetix; CVCL_2784
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number39