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Cellosaurus UM-RC-6 (CVCL_2741)

[Text version]
Cell line name UM-RC-6
Synonyms UMRC-6; UMRC6; University of Michigan-Renal Carcinoma-6
Accession CVCL_2741
Resource Identification Initiative To cite this cell line use: UM-RC-6 (RRID:CVCL_2741)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Population: African American.
Doubling time: ~43 hours (PubMed=4038766).
Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
Sequence variations
  • Mutation; HGNC; HGNC:12687; VHL; Simple; p.Val170Argfs*29 (c.502_511del10); Zygosity=Unspecified (PubMed=8493574).
  • Mutation; HGNC; HGNC:12687; VHL; Simple; p.Ser168Argfs*3 (c.504_511del); Zygosity=Unspecified (PubMed=7915601).
Genome ancestry Source: PubMed=30894373

Origin% genome
African81.78
Native American0.05
East Asian, North2.02
East Asian, South0
South Asian0
European, North4.24
European, South11.91
Disease Renal cell carcinoma (NCIt: C9385)
Renal cell carcinoma (ORDO: Orphanet_217071)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): ECACC=08090513; PubMed=25877200

Markers:
AmelogeninX,Y
CSF1PO8,12
D2S133819,22
D3S135816
D5S81812
D7S82010,12
D8S117912,13
D13S31712
D16S5399,10
D18S5118
D19S43314,18.2
D21S1128
FGA22
Penta D7
Penta E8
TH016
TPOX10
vWA18

Run an STR similarity search on this cell line
Web pages Info; Thermo Fisher; -; https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/u/cell-lines-detail-317.html
Publications

PubMed=4038766; DOI=10.1002/jso.2930280320
Herbert Barton Grossman, Gary Wedemeyer, Li-Qin Ren;
Human renal carcinoma: characterization of five new cell lines.
J. Surg. Oncol. 28:237-244(1985)

PubMed=8493574; DOI=10.1126/science.8493574
Farida Latif, Kalman Tory, James R. Gnarra, Masahiro Yao, Fuh-Mei Duh, Mary Lou Orcutt, Thomas Stackhouse, Igor A. Kuzmin, William S. Modi, Laura Geil, Laura S. Schmidt ...Show all 33 authors... , Fang-Wei Zhou, Hua Li, Ming Hui Wei, Fan Chen, Gladys Glenn, Peter Choyke, McClellan Milton Walther, Yong-Kai Weng, Dah-Shuhn R. Duan, Michael Dean, Damjan Glavac, Frances M. Richards, Paul A. Crossey, Malcolm Andrew Ferguson-Smith, Denis Le Paslier, Ilya Chumakov, Daniel Cohen, Alan Craig Chinault, Eamonn R. Maher, William Marston Linehan, Berton Zbar, Michael I. Lerman; Show fewer authors
Identification of the von Hippel-Lindau disease tumor suppressor gene.
Science 260:1317-1320(1993)

PubMed=7915601; DOI=10.1038/ng0594-85
James R. Gnarra, Kalman Tory, Yong-Kai Weng, Laura S. Schmidt, Ming Hui Wei, H. Li, Farida Latif, S. Liu, Fan Chen, Fuh-Mei Duh, Irina A. Lubensky ...Show all 24 authors... , Dah-Shuhn R. Duan, Charles Florence, Rudy Pozzatti, McClellan Milton Walther, Neil Harrison Bander, Herbert Barton Grossman, Hiltrud Brauch, Sigmund Pomer, James D. Brooks, William B. Isaacs, Michael I. Lerman, Berton Zbar, William Marston Linehan; Show fewer authors
Mutations of the VHL tumour suppressor gene in renal carcinoma.
Nat. Genet. 7:85-90(1994)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=28489074; DOI=10.1038/ncomms15165; PMCID=PMC5436135
Rileen Sinha, Andrew G. Winer, Michael Stephen Chevinsky, Christopher Jakubowski, Ying-Bei Chen, Yi-Yu Dong, Satish K. Tickoo, Victor E. Reuter, Paul Russo, Jonathan A. Coleman, Chris Sander ...Show all 13 authors... , James J.-D. Hsieh, Abraham Ari Hakimi; Show fewer authors
Analysis of renal cancer cell lines from two major resources enables genomics-guided cell line selection.
Nat. Commun. 8:15165.1-15165.10(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections (Providers) CancerTools; 160448
ECACC; 08090513 - Discontinued
Ximbio; 160448
Cell line databases/resources cancercelllines; CVCL_2741
Cell_Model_Passport; SIDM01829
DepMap; ACH-001225
Biological sample resources BioSample; SAMN03470958
Chemistry resources PharmacoDB; UMRC6_1646_2019
Encyclopedic resources Wikidata; Q54990787
Gene expression databases GEO; GSM374477
Polymorphism and mutation databases Cosmic; 972873
Cosmic; 972913
Cosmic; 1779196
Progenetix; CVCL_2741
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number28