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Cellosaurus UM-RC-6 (CVCL_2741)

[Text version]
Cell line name UM-RC-6
Synonyms UMRC-6; UMRC6; University of Michigan-Renal Carcinoma-6
Accession CVCL_2741
Resource Identification Initiative To cite this cell line use: UM-RC-6 (RRID:CVCL_2741)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Population: African American.
Doubling time: ~43 hours (PubMed=4038766).
Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
Sequence variations
  • Mutation; HGNC; 12687; VHL; Simple; p.Ser168Argfs*3 (c.504_511del); Zygosity=Unspecified (PubMed=7915601).
  • Mutation; HGNC; 12687; VHL; Simple; p.Val170Argfs*29 (c.502_511del10); Zygosity=Unspecified (PubMed=8493574).
Genome ancestry Source: PubMed=30894373

Origin% genome
Native American0.05
East Asian, North2.02
East Asian, South0
South Asian0
European, North4.24
European, South11.91
Disease Renal cell carcinoma (NCIt: C9385)
Renal cell carcinoma (ORDO: Orphanet_217071)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): ECACC=08090513; PubMed=25877200

Penta D7
Penta E8

Run an STR similarity search on this cell line
Web pages https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/u/cell-lines-detail-317.html

PubMed=4038766; DOI=10.1002/jso.2930280320
Grossman H.B., Wedemeyer G., Ren L.-Q.
Human renal carcinoma: characterization of five new cell lines.
J. Surg. Oncol. 28:237-244(1985)

PubMed=8493574; DOI=10.1126/science.8493574
Latif F., Tory K., Gnarra J.R., Yao M., Duh F.-M., Orcutt M.L., Stackhouse T., Kuzmin I.A., Modi W., Geil L., Schmidt L.S., Zhou F.-W., Li H., Wei M.H., Chen F., Glenn G., Choyke P., Walther M.M., Weng Y.-K., Duan D.-S.R., Dean M., Glavac D., Richards F.M., Crossey P.A., Ferguson-Smith M.A., Le Paslier D., Chumakov I., Cohen D., Chinault A.C., Maher E.R., Linehan W.M., Zbar B., Lerman M.I.
Identification of the von Hippel-Lindau disease tumor suppressor gene.
Science 260:1317-1320(1993)

PubMed=7915601; DOI=10.1038/ng0594-85
Gnarra J.R., Tory K., Weng Y., Schmidt L.S., Wei M.H., Li H., Latif F., Liu S., Chen F., Duh F.-M., Lubensky I.A., Duan D.R., Florence C., Pozzatti R., Walther M.M., Bander N.H., Grossman H.B., Brauch H., Pomer S., Brooks J.D., Isaacs W.B., Lerman M.I., Zbar B., Linehan W.M.
Mutations of the VHL tumour suppressor gene in renal carcinoma.
Nat. Genet. 7:85-90(1994)

PubMed=25877200; DOI=10.1038/nature14397
Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M., Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S., Neve R.M.
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=28489074; DOI=10.1038/ncomms15165
Sinha R., Winer A.G., Chevinsky M., Jakubowski C., Chen Y.-B., Dong Y.-Y., Tickoo S.K., Reuter V.E., Russo P., Coleman J.A., Sander C., Hsieh J.J.-D., Hakimi A.A.
Analysis of renal cancer cell lines from two major resources enables genomics-guided cell line selection.
Nat. Commun. 8:15165.1-15165.10(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cell line collections (Providers) CancerTools; 160448
ECACC; 08090513
Ximbio; 160448
Cell line databases/resources cancercelllines; CVCL_2741
Cell_Model_Passport; SIDM01829
DepMap; ACH-001225
Biological sample resources BioSample; SAMN03470958
Chemistry resources PharmacoDB; UMRC6_1646_2019
Encyclopedic resources Wikidata; Q54990787
Gene expression databases GEO; GSM374477
Polymorphism and mutation databases Cosmic; 972873
Cosmic; 972913
Cosmic; 1779196
Progenetix; CVCL_2741
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number25