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Cellosaurus RB247C (CVCL_2704)

[Text version]
Cell line name RB247C
Synonyms RB247c; RB247; RB 247; Rb247; RB247C-3; RB247C3; RB247c3
Accession CVCL_2704
Resource Identification Initiative To cite this cell line use: RB247C (RRID:CVCL_2704)
Comments Omics: Transcriptomics; Microarray.
Sequence variations
  • Mutation; HGNC; HGNC:9884; RB1; Simple; p.Pro39Argfs*26 (c.116delC); Zygosity=Heterozygous (PubMed=30584916).
  • Mutation; HGNC; HGNC:9884; RB1; Simple; p.Gly617Argfs*36 (c.1848dup); Zygosity=Heterozygous (PubMed=30584916).
Disease Bilateral retinoblastoma (NCIt: C8713)
Retinoblastoma (ORDO: Orphanet_790)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=2751270
Helen S.L. Chan, Marc D. Canton, Brenda Louise Gallie;
Chemosensitivity and multidrug resistance to antineoplastic drugs in retinoblastoma cell lines.
Anticancer Res. 9:469-474(1989)

PubMed=2090524; DOI=10.1111/j.1432-0436.1990.tb00479.x
Sabine Griegel, Kerstin Heise, Andrea Kindler-Rohrborn, Manfred Fedor Rajewsky;
In vitro differentiation of human retinoblastoma cells into neuronal phenotypes.
Differentiation 45:250-257(1990)

PubMed=2365495; DOI=10.1002/ijc.2910460123
Sabine Griegel, Chen Hong, Roland Frotschl, Dieter F. Hulser, Valerie Greger, Bernhard Horsthemke, Manfred Fedor Rajewsky;
Newly established human retinoblastoma cell lines exhibit an 'immortalized' but not an invasive phenotype in vitro.
Int. J. Cancer 46:125-132(1990)

PubMed=1682862; DOI=10.1016/S0161-6420(91)32134-1
Helen S.L. Chan, Paul Scott Thorner, George Haddad, Brenda Louise Gallie;
Multidrug-resistant phenotype in retinoblastoma correlates with P-glycoprotein expression.
Ophthalmology 98:1425-1431(1991)

PubMed=11520568; DOI=10.1016/S0165-4608(01)00427-7
Danian Chen, Brenda Louise Gallie, Jeremy Andrew Squire;
Minimal regions of chromosomal imbalance in retinoblastoma detected by comparative genomic hybridization.
Cancer Genet. Cytogenet. 129:57-63(2001)

PubMed=15326157; DOI=10.1167/iovs.04-0140
David Patrick DiCiommo, Allison Duckett, Irina Burcescu, Rod Bremner, Brenda Louise Gallie;
Retinoblastoma protein purification and transduction of retina and retinoblastoma cells using improved alphavirus vectors.
Invest. Ophthalmol. Vis. Sci. 45:3320-3329(2004)

PubMed=18036396; DOI=10.1016/j.cancergencyto.2007.08.014
Jana Paderova, Marija Orlic-Milacic, Maisa Yoshimoto, Gilda da Cunha Santos, Brenda Louise Gallie, Jeremy Andrew Squire;
Novel 6p rearrangements and recurrent translocation breakpoints in retinoblastoma cell lines identified by spectral karyotyping and mBAND analyses.
Cancer Genet. Cytogenet. 179:102-111(2007)

PubMed=23498719; DOI=10.1016/S1470-2045(13)70045-7
Diane E. Rushlow, Berber M. Mol, Jennifer Y. Kennett, Stephanie Yee, Sanja Pajovic, Brigitte L. Theriault, Nadia L. Prigoda-Lee, Clarellen Spencer, Helen Dimaras, Timothy W. Corson, Renee Pang ...Show all 25 authors... , Christine Massey, Roseline Godbout, Zhe Jiang, Eldad Zacksenhaus, Katherine Paton, Annette C. Moll, Claude Houdayer, Anthony Raizis, William Halliday, Wan L. Lam, Paul Christopher Boutros, Dietmar R. Lohmann, Josephine C. Dorsman, Brenda Louise Gallie; Show fewer authors
Characterisation of retinoblastomas without RB1 mutations: genomic, gene expression, and clinical studies.
Lancet Oncol. 14:327-334(2013)

PubMed=27115612; DOI=10.1371/journal.pone.0153323; PMCID=PMC4846005
Irsan E. Kooi, Berber M. Mol, Maarten P.G. Massink, Marcus C. de Jong, Pim de Graaf, Paul van der Valk, Hanne Meijers-Heijboer, Gertjan J.L. Kaspers, Annette C. Moll, Hein te Riele, Jacqueline Cloos, Josephine C. Dorsman;
A meta-analysis of retinoblastoma copy numbers refines the list of possible driver genes involved in tumor progression.
PLoS ONE 11:e0153323.1-e0153323.20(2016)

PubMed=30584916; DOI=10.1016/j.yexcr.2018.12.018
Melanie Schwermer, Michaela Hiber, Sabine Dreesmann, Anja Rieb, Jessica Theissen, Thomas Herold, Alexander Schramm, Petra Temming, Laura Steenpass;
Comprehensive characterization of RB1 mutant and MYCN amplified retinoblastoma cell lines.
Exp. Cell Res. 375:92-99(2019)

PubMed=32123578; DOI=10.1038/s41420-020-0237-8; PMCID=PMC7026052
Arthur Aubry, Tao Yu, Rod Bremner;
Preclinical studies reveal MLN4924 is a promising new retinoblastoma therapy.
Cell Death Discov. 6:2.1-2.12(2020)

Cross-references
Cell line collections (Providers) ECACC; 06070601
Encyclopedic resources Wikidata; Q54949297
Gene expression databases GEO; GSM2043878
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number15