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Cellosaurus MM426 (CVCL_2609)

[Text version]
Cell line name MM426
Synonyms MM 426
Accession CVCL_2609
Resource Identification Initiative To cite this cell line use: MM426 (RRID:CVCL_2609)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Omics: CNV analysis.
Omics: Deep exome analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
Sequence variations
  • Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Unspecified (PubMed=15048078; PubMed=17363583; DepMap=ACH-001570).
  • Mutation; HGNC; 1787; CDKN2A; Simple; p.Glu88Ter (c.262G>T); ClinVar=VCV000376305; Zygosity=Unspecified (PubMed=9354451; PubMed=17363583; DepMap=ACH-001570).
Disease Melanoma (NCIt: C3224)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): CBA=CBA-1352; DepMap=ACH-001570

Markers:
AmelogeninX,Y
CSF1PO10,12
D2S133821
D3S135817
D5S8189,12
D7S8208,11
D8S117910,16
D13S3178,11
D16S53911,13
D18S5115,18
D19S43314,15
D21S1128,30
FGA23
Penta D9,11
Penta E11,14
TH018,9
TPOX8
vWA15

Run an STR similarity search on this cell line
Publications

PubMed=9354451
Castellano M., Pollock P.M., Walters M.K., Sparrow L.E., Down L.M., Gabrielli B.G., Parsons P.G., Hayward N.K.
CDKN2A/p16 is inactivated in most melanoma cell lines.
Cancer Res. 57:4868-4875(1997)

PubMed=15048078; DOI=10.1038/sj.onc.1207563
Pavey S., Johansson P., Packer L., Taylor J., Stark M.S., Pollock P.M., Walker G.J., Boyle G.M., Harper U., Cozzi S.-J., Hansen K., Yudt L., Schmidt C., Hersey P., Ellem K.A.O., O'Rourke M.G.E., Parsons P.G., Meltzer P.S., Ringner M., Hayward N.K.
Microarray expression profiling in melanoma reveals a BRAF mutation signature.
Oncogene 23:4060-4067(2004)

PubMed=17363583; DOI=10.1158/0008-5472.CAN-06-4152
Stark M.S., Hayward N.K.
Genome-wide loss of heterozygosity and copy number analysis in melanoma using high-density single-nucleotide polymorphism arrays.
Cancer Res. 67:2632-2642(2007)

PubMed=17516929; DOI=10.1111/j.1600-0749.2007.00375.x
Johansson P., Pavey S., Hayward N.K.
Confirmation of a BRAF mutation-associated gene expression signature in melanoma.
Pigment Cell Res. 20:216-221(2007)

Cross-references
Cell line collections (Providers) CBA; CBA-1352
ECACC; 10092320
Cell line databases/resources cancercelllines; CVCL_2609
Cell_Model_Passport; SIDM01382
DepMap; ACH-001570
Biological sample resources BioSample; SAMN07624430
Encyclopedic resources Wikidata; Q54906131
Gene expression databases GEO; GSM170848
GEO; GSM226718
Polymorphism and mutation databases Cosmic; 889022
Cosmic; 928740
Progenetix; CVCL_2609
Entry history
Entry creation04-Apr-2012
Last entry update10-Sep-2024
Version number25