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Cellosaurus MES-SA/MX2 (CVCL_2599)

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Cell line name MES-SA/MX2
Synonyms MES-SA/Mx2; MES-SA-MX2; MESSA/MX2; MESSAMX2
Accession CVCL_2599
Resource Identification Initiative To cite this cell line use: MES-SA/MX2 (RRID:CVCL_2599)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_50729; Mitoxantrone.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Uterus; UBERON=UBERON_0000995.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11110; ARID1A; Simple; p.Gly1610Trpfs*38 (c.4826dupC) (p.S1609fs) (c.4825_4826insC); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11110; ARID1A; Simple; p.Thr1690Asnfs*8 (c.5068dupA) (c.5067_5068insA); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.His272Thrfs*4 (c.813delT) (p.Phe271fs) (c.811delT); ClinVar=VCV000428208; Zygosity=Heterozygous (from parent cell line).
Disease Uterine corpus sarcoma (NCIt: C6339)
Sarcoma of the corpus uteri (ORDO: Orphanet_213620)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1404 (MES-SA)
Sex of cell Female
Age at sampling 56Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-2274

Markers:
AmelogeninX
CSF1PO11
D2S133817
D3S135814
D5S81813
D7S8207,11
D8S117914,15
D13S31713
D16S53911,12
D18S5112
D19S43314.2,15
D21S1129,30.2
FGA20,25
Penta D13,15
Penta E7,10
TH016
TPOX8,12
vWA18

Run an STR similarity search on this cell line
Publications

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

Cross-references
Cell line collections (Providers) ATCC; CRL-2274
Cell line databases/resources CLO; CLO_0007679
cancercelllines; CVCL_2599
Cell_Model_Passport; SIDM01239
IGRhCellID; MESSAMX2
Biological sample resources BioSample; SAMN03471858
Encyclopedic resources Wikidata; Q54905252
Gene expression databases ArrayExpress; E-MTAB-38
Polymorphism and mutation databases Progenetix; CVCL_2599
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number22