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Cellosaurus LO68 (CVCL_2581)

[Text version]
Cell line name LO68
Accession CVCL_2581
Resource Identification Initiative To cite this cell line use: LO68 (RRID:CVCL_2581)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Transformant: ChEBI; CHEBI_46666; Crocidolite asbestos.
Omics: Proteomics; Subcellular; Exosome.
Omics: Proteomics; Subcellular; Secretome.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Disease Pleural epithelioid mesothelioma (NCIt: C45662)
Pleural mesothelioma (ORDO: Orphanet_50251)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 57Y
Category Cancer cell line
STR profile Source(s): CBA=CBA-0141

Markers:
AmelogeninX
CSF1PO10,11
D2S133820,24
D3S135816,18
D5S81811,13
D7S8208,10
D8S117914
D13S31711
D16S53910,12
D18S5112,15
D19S43313,15.2
D21S1130,30.2
FGA20,22
TH018,9
TPOX8,11
vWA17,18

Run an STR similarity search on this cell line
Publications

PubMed=1703129; DOI=10.1002/ijc.2910470219
Linda S. Manning, Darrel Whitaker, Ashleigh R. Murch, Michael J. Garlepp, Mark R. Davis, Arthur William Musk, Bruce William Stanley Robinson;
Establishment and characterization of five human malignant mesothelioma cell lines derived from pleural effusions.
Int. J. Cancer 47:285-290(1991)

PubMed=21642991; DOI=10.1038/ng.855; PMCID=PMC4643098
Matthew J. Bott, Marie Brevet, Barry Stephen Taylor, Shigeki Shimizu, Tatsuo Ito, Lu Wang, Jenette Creaney, Richard A. Lake, Maureen F. Zakowski, Boris A. Reva, Chris Sander ...Show all 18 authors... , Robert Delsite, Simon N. Powell, Qin Zhou, Rong-Lai Shen, Adam B. Olshen, Valerie W. Rusch, Marc Ladanyi; Show fewer authors
The nuclear deubiquitinase BAP1 is commonly inactivated by somatic mutations and 3p21.1 losses in malignant pleural mesothelioma.
Nat. Genet. 43:668-672(2011)

PubMed=25902174; DOI=10.1097/JTO.0000000000000493
Akihiko Miyanaga, Mari Masuda, Koji Tsuta, Kumiko Kawasaki, Yuka Nakamura, Tomohiro Sakuma, Hisao Asamura, Akihiko Gemma, Tesshi Yamada;
Hippo pathway gene mutations in malignant mesothelioma: revealed by RNA and targeted exon sequencing.
J. Thorac. Oncol. 10:844-851(2015)

PubMed=27605433; DOI=10.1038/srep32643; PMCID=PMC5015102
David W. Greening, Hong Ji, Mao-Shan Chen, Bruce William Stanley Robinson, Ian M. Dick, Jenette Creaney, Richard J. Simpson;
Secreted primary human malignant mesothelioma exosome signature reflects oncogenic cargo.
Sci. Rep. 6:32643-32643(2016)

PubMed=28387650; DOI=10.21873/cgp.20023; PMCID=PMC5369310
Jenette Creaney, Ian M. Dick, Justine S. Leon, Bruce William Stanley Robinson;
A proteomic analysis of the malignant mesothelioma secretome using iTRAQ.
Cancer Genomics Proteomics 14:103-117(2017)

Cross-references
Cell line collections (Providers) CBA; CBA-0141
ECACC; 10092311
Cell line databases/resources cancercelllines; CVCL_2581
DepMap; ACH-001547
Biological sample resources BioSample; SAMN07624410
BioSamples; SAMEA100921
Encyclopedic resources Wikidata; Q54902877
Gene expression databases GEO; GSM726273
Polymorphism and mutation databases Cosmic; 1522778
Cosmic; 1963330
Progenetix; CVCL_2581
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number22