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Cellosaurus HSG (CVCL_2517)

[Text version]
Cell line name HSG
Synonyms Human Salivary Gland
Accession CVCL_2517
Resource Identification Initiative To cite this cell line use: HSG (RRID:CVCL_2517)
Comments Problematic cell line: Contaminated. Shown to be a HeLa derivative (PubMed=20143388; PubMed=29923277; CelloPub=CLPUB00653). Originally thought to originate from a 54 year old male irradiated submandibular salivary gland.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00313.
Population: African American.
Doubling time: 29 hours (DOI=10.2330/joralbiosci1965.34.164).
Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
Omics: Proteome analysis by 2D-DE/MS.
Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
Disease Human papillomavirus-related cervical adenocarcinoma (NCIt: C27677)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0030 (HeLa)
CVCL_WL38 (HSG-S8)CVCL_2951 (HSGc-C5)
Sex of cell Female
Age at sampling 30Y6M
Category Cancer cell line
STR profile Source(s): CelloPub=CLPUB00653; JCRB=CHB0004; PubMed=29923277

D5S81810,11 (CelloPub=CLPUB00653; PubMed=29923277)
11 (JCRB=CHB0004)
Penta D8,15
Penta E7,17

Run an STR similarity search on this cell line
Web pages http://www.cells-talk.com/index.php/page/copelibrary?key=HSG

PubMed=7248901; DOI=10.1002/1097-0142(19810801)48:3<745::AID-CNCR2820480314>3.0.CO;2-7
Shirasuna K., Sato M., Miyazaki T.
A neoplastic epithelial duct cell line established from an irradiated human salivary gland.
Cancer 48:745-752(1981)

Sato M., Azuma M., Hayashi Y., Yoshida H., Yanagawa T., Yura Y.
5-azacytidine induction of stable myoepithelial and acinar cells from a human salivary intercalated duct cell clone.
Cancer Res. 47:4453-4459(1987)

Hatakeyama S., Suzuki A.
Isolation of salivary adenocarcinoma cell's subclone with in vivo activity of bone and cartilage fomation in serum-free culture.
Jpn. J. Oral Biol. 34:164-168(1992)

Ota M., Kyakumoto S., Sato N.
Proliferation and differentiation of human salivary gland adenocarcinoma cell line HSG.
Hum. Cell 9:79-88(1996)

Sato M.
Salivary gland tumors.
(In) Human cell culture. Vol. 1. Cancer cell lines part 1; Masters J.R.W., Palsson B.O. (eds.); pp.161-178; Kluwer Academic Publishers; New York (1999)

PubMed=16391823; DOI=10.3892/ijmm.17.2.253
Kasamatsu A., Uzawa K., Nakashima D., Kouzu Y., Endo Y., Koike H., Yokoe H., Harada K., Sato M., Tanzawa H.
A proteomics approach to characterizing human submandibular gland cell lines by fluorescent two-dimensional differential in-gel electrophoresis.
Int. J. Mol. Med. 17:253-260(2006)

PubMed=17390010; DOI=10.3892/ijo.30.5.1089
Kawamata H., Omotehara F., Nakashiro K.-i., Uchida D., Shinagawa Y., Tachibana M., Imai Y., Fujimori T.
Oncogenic mutation of the p53 gene derived from head and neck cancer prevents cells from undergoing apoptosis after DNA damage.
Int. J. Oncol. 30:1089-1097(2007)

PubMed=20143388; DOI=10.1002/ijc.25242
Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A., MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R., Freshney R.I.
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

Lin L.-C.
A new tool in human salivary gland research: the SMG-hu-1 cell line.
Thesis MDSc (2017), McGill University Montreal, Canada

PubMed=29923277; DOI=10.1111/odi.12920
Lin L.-C., Elkashty O., Ramamoorthi M., Trinh N., Liu Y.-N., Sunavala-Dossabhoy G., Pranzatelli T.J.F., Michael D.G., Chivasso C., Perret J., Chiorini J.A., Delporte C., Tran S.D.
Cross-contamination of the human salivary gland HSG cell line with HeLa cells: a STR analysis study.
Oral Dis. 24:1477-1483(2018)

Cell line collections (Providers) ECACC; 95031024
JCRB; CHB0004 - Discontinued
Cell line databases/resources CLO; CLO_0004263
Biological sample resources BioSample; SAMN03151712
BioSample; SAMN03471295
Encyclopedic resources Wikidata; Q54896445
Polymorphism and mutation databases Cosmic; 974319
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number24