Cellosaurus logo
expasy logo
Due to maintenance work, this service will be unavailable on Monday between 06:00 until 06:30 CEST. Apologies for the inconvenience.

Cellosaurus HRA-19 (CVCL_2508)

[Text version]
Cell line name HRA-19
Synonyms HRA 19; HRA19
Accession CVCL_2508
Resource Identification Initiative To cite this cell line use: HRA-19 (RRID:CVCL_2508)
Comments Part of: AstraZeneca Colorectal cell line (AZCL) panel.
Microsatellite instability: Stable (MSS) (PubMed=24755471).
Omics: Deep proteome analysis.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Rectum; UBERON=UBERON_0001052.
Sequence variations
  • Mutation; HGNC; 583; APC; Simple; p.Arg405Ter (c.1213C>T); ClinVar=VCV000127275; Zygosity=Unspecified (PubMed=24755471).
  • Mutation; HGNC; 583; APC; Simple; p.Arg1450Ter (c.4348C>T); ClinVar=VCV000194585; Zygosity=Unspecified (PubMed=24755471).
  • Mutation; HGNC; 914; B2M; Simple; p.Ser16Alafs*27 (c.42_45delTCTT); Zygosity=Heterozygous (PubMed=8197130).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Unspecified (PubMed=16418264; PubMed=24755471).
Disease Rectal adenocarcinoma (NCIt: C9383)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_2509 (HRA-19a1.1)
Sex of cell Male
Age at sampling 66Y
Category Cancer cell line
STR profile Source(s): ECACC=10012802

Markers:
AmelogeninX,Y
CSF1PO12
D5S81811
D7S8209,12
D13S31711,12
D16S53911
TH018
TPOX11
vWA16

Run an STR similarity search on this cell line
Publications

PubMed=3569697; DOI=10.1111/j.1432-0436.1987.tb01551.x
Kirkland S.C.
Endocrine differentiation by a human rectal adenocarcinoma cell line (HRA-19).
Differentiation 33:148-155(1986)

PubMed=3718830; DOI=10.1038/bjc.1986.132
Kirkland S.C., Bailey I.G.
Establishment and characterisation of six human colorectal adenocarcinoma cell lines.
Br. J. Cancer 53:779-785(1986)

PubMed=8197130; DOI=10.1073/pnas.91.11.4751
Bicknell D.C., Rowan A.J., Bodmer W.F.
Beta 2-microglobulin gene mutations: a study of established colorectal cell lines and fresh tumors.
Proc. Natl. Acad. Sci. U.S.A. 91:4751-4755(1994)

PubMed=9294210; DOI=10.1073/pnas.94.19.10330
Ilyas M., Tomlinson I.P.M., Rowan A.J., Pignatelli M., Bodmer W.F.
Beta-catenin mutations in cell lines established from human colorectal cancers.
Proc. Natl. Acad. Sci. U.S.A. 94:10330-10334(1997)

PubMed=10737795; DOI=10.1073/pnas.97.7.3352
Rowan A.J., Lamlum H., Ilyas M., Wheeler J., Straub J., Papadopoulou A., Bicknell D.C., Bodmer W.F., Tomlinson I.P.M.
APC mutations in sporadic colorectal tumors: a mutational 'hotspot' and interdependence of the 'two hits'.
Proc. Natl. Acad. Sci. U.S.A. 97:3352-3357(2000)

PubMed=16418264; DOI=10.1073/pnas.0510146103
Liu Y., Bodmer W.F.
Analysis of P53 mutations and their expression in 56 colorectal cancer cell lines.
Proc. Natl. Acad. Sci. U.S.A. 103:976-981(2006)

PubMed=18258742; DOI=10.1073/pnas.0712176105
Emaduddin M., Bicknell D.C., Bodmer W.F., Feller S.M.
Cell growth, global phosphotyrosine elevation, and c-Met phosphorylation through Src family kinases in colorectal cancer cells.
Proc. Natl. Acad. Sci. U.S.A. 105:2358-2362(2008)

PubMed=20606684; DOI=10.1038/sj.bjc.6605780
Bracht K., Nicholls A.M., Liu Y., Bodmer W.F.
5-fluorouracil response in a large panel of colorectal cancer cell lines is associated with mismatch repair deficiency.
Br. J. Cancer 103:340-346(2010)

PubMed=23272949; DOI=10.1186/1755-8794-5-66
Schlicker A., Beran G., Chresta C.M., McWalter G., Pritchard A., Weston S., Runswick S., Davenport S., Heathcote K., Castro D.A., Orphanides G., French T., Wessels L.F.A.
Subtypes of primary colorectal tumors correlate with response to targeted treatment in colorectal cell lines.
BMC Med. Genomics 5:66.1-66.15(2012)

PubMed=24755471; DOI=10.1158/0008-5472.CAN-14-0013
Mouradov D., Sloggett C., Jorissen R.N., Love C.G., Li S., Burgess A.W., Arango D., Strausberg R.L., Buchanan D., Wormald S., O'Connor L., Wilding J.L., Bicknell D.C., Tomlinson I.P.M., Bodmer W.F., Mariadason J.M., Sieber O.M.
Colorectal cancer cell lines are representative models of the main molecular subtypes of primary cancer.
Cancer Res. 74:3238-3247(2014)

PubMed=29101300; DOI=10.15252/msb.20177701
Frejno M., Zenezini Chiozzi R., Wilhelm M., Koch H., Zheng R.-S., Klaeger S., Ruprecht B., Meng C., Kramer K., Jarzab A., Heinzlmeir S., Johnstone E., Domingo E., Kerr D., Jesinghaus M., Slotta-Huspenina J., Weichert W., Knapp S., Feller S.M., Kuster B.
Pharmacoproteomic characterisation of human colon and rectal cancer.
Mol. Syst. Biol. 13:951-951(2017)

Cross-references
Cell line collections (Providers) ECACC; 10012802
Ximbio; 152465 - Discontinued
Cell line databases/resources cancercelllines; CVCL_2508
ColonAtlas; HRA19
Encyclopedic resources Wikidata; Q54895214
Gene expression databases GEO; GSM1346842
GEO; GSM1374548
Polymorphism and mutation databases Cosmic; 876723
Cosmic; 948851
Cosmic; 986014
Cosmic; 995408
Cosmic; 1043816
Cosmic; 1312302
Cosmic; 2301986
Cosmic; 2760063
Cosmic; 2800564
IARC_TP53; 21738
Proteomic databases PRIDE; PXD005354
PRIDE; PXD005355
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number27