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Cellosaurus HRA-19 (CVCL_2508)

[Text version]
Cell line name HRA-19
Synonyms HRA 19; HRA19
Accession CVCL_2508
Resource Identification Initiative To cite this cell line use: HRA-19 (RRID:CVCL_2508)
Comments Part of: AstraZeneca Colorectal cell line (AZCL) panel.
Microsatellite instability: Stable (MSS) (PubMed=24755471).
Omics: Proteomics.
Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Rectum; UBERON=UBERON_0001052.
Sequence variations
Disease Rectal adenocarcinoma (NCIt: C9383)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_2509 (HRA-19a1.1)
Sex of cell Male
Age at sampling 66Y
Category Cancer cell line
STR profile Source(s): ECACC=10012802

Markers:
AmelogeninX,Y
CSF1PO12
D5S81811
D7S8209,12
D13S31711,12
D16S53911
TH018
TPOX11
vWA16

Run an STR similarity search on this cell line
Publications

PubMed=3569697; DOI=10.1111/j.1432-0436.1987.tb01551.x
Susan C. Kirkland;
Endocrine differentiation by a human rectal adenocarcinoma cell line (HRA-19).
Differentiation 33:148-155(1986)

PubMed=3718830; DOI=10.1038/bjc.1986.132; PMCID=PMC2001395
Susan C. Kirkland, I.G. Bailey;
Establishment and characterisation of six human colorectal adenocarcinoma cell lines.
Br. J. Cancer 53:779-785(1986)

PubMed=8197130; DOI=10.1073/pnas.91.11.4751; PMCID=PMC43866
David C. Bicknell, Andrew J. Rowan, Walter Fred Bodmer;
Beta 2-microglobulin gene mutations: a study of established colorectal cell lines and fresh tumors.
Proc. Natl. Acad. Sci. U.S.A. 91:4751-4755(1994)

PubMed=9294210; DOI=10.1073/pnas.94.19.10330; PMCID=PMC23362
Mohammad Ilyas, Ian Philip Mark Tomlinson, Andrew J. Rowan, Massimo Pignatelli, Walter Fred Bodmer;
Beta-catenin mutations in cell lines established from human colorectal cancers.
Proc. Natl. Acad. Sci. U.S.A. 94:10330-10334(1997)

PubMed=10737795; DOI=10.1073/pnas.97.7.3352; PMCID=PMC16243
Andrew J. Rowan, Hanan Lamlum, Mohammad Ilyas, James M.D. Wheeler, Jannes Straub, Angeliki Papadopoulou, David C. Bicknell, Walter Fred Bodmer, Ian Philip Mark Tomlinson;
APC mutations in sporadic colorectal tumors: a mutational 'hotspot' and interdependence of the 'two hits'.
Proc. Natl. Acad. Sci. U.S.A. 97:3352-3357(2000)

PubMed=16418264; DOI=10.1073/pnas.0510146103; PMCID=PMC1327731
Ying Liu, Walter Fred Bodmer;
Analysis of p53 mutations and their expression in 56 colorectal cancer cell lines.
Proc. Natl. Acad. Sci. U.S.A. 103:976-981(2006)

PubMed=18258742; DOI=10.1073/pnas.0712176105; PMCID=PMC2268141
Muhammad Emaduddin, David C. Bicknell, Walter Fred Bodmer, Stephan M. Feller;
Cell growth, global phosphotyrosine elevation, and c-Met phosphorylation through Src family kinases in colorectal cancer cells.
Proc. Natl. Acad. Sci. U.S.A. 105:2358-2362(2008)

PubMed=20606684; DOI=10.1038/sj.bjc.6605780; PMCID=PMC2920028
Karin Bracht, Angela M. Nicholls, Ying Liu, Walter Fred Bodmer;
5-fluorouracil response in a large panel of colorectal cancer cell lines is associated with mismatch repair deficiency.
Br. J. Cancer 103:340-346(2010)

PubMed=23272949; DOI=10.1186/1755-8794-5-66; PMCID=PMC3543849
Andreas Schlicker, Garry Beran, Christine M. Chresta, Gael McWalter, Alison Pritchard, Susie Weston, Sarah Runswick, Sara Davenport, Kerry Heathcote, Denis Alferez Castro, George Orphanides ...Show all 13 authors... , Tim French, Lodewyk F.A. Wessels; Show fewer authors
Subtypes of primary colorectal tumors correlate with response to targeted treatment in colorectal cell lines.
BMC Med. Genomics 5:66.1-66.15(2012)

PubMed=24755471; DOI=10.1158/0008-5472.CAN-14-0013
Dmitri Mouradov, Clare Sloggett, Robert N. Jorissen, Christopher G. Love, Shan Li, Antony Wilks Burgess, Diego Arango, Robert L. Strausberg, Daniel Buchanan, Samuel Wormald, Liam O'Connor ...Show all 17 authors... , Jennifer L. Wilding, David C. Bicknell, Ian Philip Mark Tomlinson, Walter Fred Bodmer, John M. Mariadason, Oliver M. Sieber; Show fewer authors
Colorectal cancer cell lines are representative models of the main molecular subtypes of primary cancer.
Cancer Res. 74:3238-3247(2014)

PubMed=29101300; DOI=10.15252/msb.20177701; PMCID=PMC5731344
Martin Frejno, Riccardo Zenezini Chiozzi, Mathias Wilhelm, Heiner Koch, Run-Sheng Zheng, Susan Klaeger, Benjamin Ruprecht, Chen Meng, Karl Kramer, Anna Jarzab, Stephanie Heinzlmeir ...Show all 20 authors... , Elaine Johnstone, Enric Domingo, David James Kerr, Moritz Jesinghaus, Julia Slotta-Huspenina, Wilko Weichert, Stefan Knapp, Stephan M. Feller, Bernhard Kuster; Show fewer authors
Pharmacoproteomic characterisation of human colon and rectal cancer.
Mol. Syst. Biol. 13:951-951(2017)

Cross-references
Cell line collections (Providers) ECACC; 10012802
Ximbio; 152465 - Discontinued
Cell line databases/resources cancercelllines; CVCL_2508
ColonAtlas; HRA19
Encyclopedic resources Wikidata; Q54895214
Gene expression databases GEO; GSM1346842
GEO; GSM1374548
Polymorphism and mutation databases Cosmic; 876723
Cosmic; 948851
Cosmic; 986014
Cosmic; 995408
Cosmic; 1043816
Cosmic; 1312302
Cosmic; 2301986
Cosmic; 2760063
Cosmic; 2800564
IARC_TP53; 21738
Proteomic databases PRIDE; PXD005354
PRIDE; PXD005355
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number29