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Cellosaurus H69V (CVCL_2466)

[Text version]
Cell line name H69V
Synonyms H69v; MOG-H69V
Accession CVCL_2466
Secondary accession CVCL_S829
Resource Identification Initiative To cite this cell line use: H69V (RRID:CVCL_2466)
Comments Population: Caucasian.
Doubling time: 34.0 hours (PubMed=1662924).
Omics: Variations; SNP array analysis.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Gly106_Arg108del (c.317_325delGGCAACCGT); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9884; RB1; Simple; p.Glu748Ter (c.2242G>T); ClinVar=VCV000013078; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu171Ter (c.511G>T); ClinVar=VCV000634771; Zygosity=Homozygous (from parent cell line).
Disease Lung small cell carcinoma (NCIt: C4917)
Small cell lung cancer (ORDO: Orphanet_70573)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1579 (NCI-H69)
Sex of cell Male
Age at sampling 55Y
Category Cancer cell line
STR profile Source(s): ECACC=91091803

Markers:
AmelogeninX,Y
CSF1PO10,12
D5S81811,13
D7S8209
D13S31712
D16S53911
TH018,9
TPOX10
vWA16,17

Run an STR similarity search on this cell line
Publications

PubMed=1662924
Muhammad Zalaan Khan, Robert Ian Freshney, Alison M.B. Moir, Stephen Merry, John A. Plumb, Anne Marie McNicol;
Identification and characterisation in vitro of cells with a non-SCLC cell-like phenotype derived from a continuous SCLC cell line.
Anticancer Res. 11:1687-1695(1991)

PubMed=8712684
Muhammad Zalaan Khan, Anne Marie McNicol, Robert Ian Freshney;
Tumorigenicity, invasion and metastasis of the small cell lung cancer cell line NCI-H69 and two derivative lines MOG-H69V and MOG-H69VZ.
Anticancer Res. 16:1659-1669(1996)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

Cross-references
Cell line collections (Providers) ECACC; 91091803
Cell line databases/resources CLO; CLO_0003611
CLDB; cl1554
cancercelllines; CVCL_2466
LINCS_LDP; LCL-1875
Encyclopedic resources Wikidata; Q54872208
Gene expression databases GEO; GSM827449
Polymorphism and mutation databases Progenetix; CVCL_2466
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number27