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Cellosaurus H157 (CVCL_2458)

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Cell line name H157
Accession CVCL_2458
Resource Identification Initiative To cite this cell line use: H157 (RRID:CVCL_2458)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Derived from site: In situ; Oral cavity, buccal mucosa; UBERON=UBERON_0006956.
Sequence variations
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Arg80Ter (c.237_238CC>TT) (c.237_238delinsTT) (p.Pro94Leu, c.280_281CC>TT); Zygosity=Homozygous (DepMap=ACH-001347).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg306Ter (c.916C>T); ClinVar=VCV000142144; Zygosity=Homozygous (PubMed=7633286; DepMap=ACH-001347).
Disease Buccal mucosa squamous cell carcinoma (NCIt: C4040)
Squamous cell carcinoma of the oral cavity (ORDO: Orphanet_502363)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 84Y
Category Cancer cell line
STR profile Source(s): CCRID=5301HUM-KCB15028YJ; DepMap=ACH-001347; ECACC=07030901

Markers:
AmelogeninX,Y
CSF1PO10
D3S135815,18
D5S81810,11
D7S8209
D8S117913,15
D13S3178,12
D16S53911
D18S5120,22
D21S1128,29
FGA19,20
Penta D12
Penta E7,11
TH019.3
TPOX8
vWA16

Run an STR similarity search on this cell line
Publications

PubMed=1692339; DOI=10.1002/path.1711600313
Stephen S. Prime, Sally V.R. Nixon, Isabel J. Crane, Andrea Stone, John B. Matthews, Norman J. Maitland, Lucy Remnant, Susan K. Powell, Stephen M. Game, Crispian Scully;
The behaviour of human oral squamous cell carcinoma in cell culture.
J. Pathol. 160:259-269(1990)

PubMed=1744799; DOI=10.1002/path.1711650208
Serdar Mutlu, John B. Matthews, Marsh Midda, Crispian Scully, Stephen S. Prime;
MHC antigen expression in human oral squamous carcinoma cell lines.
J. Pathol. 165:129-136(1991)

PubMed=7633286; DOI=10.1016/0964-1955(94)00030-8
William Andrew Yeudall, Ian C. Paterson, Vyomesh Patel, Stephen S. Prime;
Presence of human papillomavirus sequences in tumour-derived human oral keratinocytes expressing mutant p53.
Eur. J. Cancer B. Oral Oncol. 31:136-143(1995)

Cross-references
Cell line collections (Providers) CancerTools; 153420
ECACC; 07030901 - Discontinued
KCB; KCB 2015028YJ
Ximbio; 153420
Cell line databases/resources cancercelllines; CVCL_2458
CCRID; 5301HUM-KCB15028YJ
Cell_Model_Passport; SIDM01808
DepMap; ACH-001347
Encyclopedic resources Wikidata; Q54871942
Experimental variables resources EFO; EFO_0022634
Polymorphism and mutation databases Cosmic; 716674
Cosmic; 916368
Cosmic; 928235
Entry history
Entry creation04-Apr-2012
Last entry update19-Dec-2024
Version number24