Cellosaurus logo
expasy logo

Cellosaurus Detroit 6 (CVCL_2436)

[Text version]
Cell line name Detroit 6
Synonyms Detroit-6; Det-6; Det6
Accession CVCL_2436
Resource Identification Initiative To cite this cell line use: Detroit 6 (RRID:CVCL_2436)
Comments Problematic cell line: Contaminated. Shown to be a HeLa derivative (PubMed=4864103; PubMed=5641128; PubMed=1246601; PubMed=20143388). Originally thought to originate from the bone marrow of a 58 year old male lung carcinoma patient.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00004.
Population: African American.
Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
Derived from sampling site: Uterus; cervix.
Disease Human papillomavirus-related endocervical adenocarcinoma (NCIt: C27677)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0030 (HeLa)
CVCL_M618 (Detroit 6 clone 12)
Sex of cell Female
Age at sampling 30Y6M
Category Cancer cell line
Web pages https://iclac.org/wp-content/uploads/Cross-Contaminations_v12_distribution.xlsx

Berman L., Stulberg C.S., Ruddle F.H.
Epithelium-like cells derived from tissue cultures of human bone marrow and ascitic fluid.
J. Mich. State Med. Soc. 55:269-271(1956)

PubMed=13370509; DOI=10.3181/00379727-92-22595
Berman L., Stulberg C.S.
Eight culture strains (Detroit) of human epithelial-like cells.
Proc. Soc. Exp. Biol. Med. 92:730-735(1956)

Berman L., Stulberg C.S., Ruddle F.H.
Human cell culture: morphology of the Detroit strains.
Cancer Res. 17:668-676(1957)

PubMed=14185313; DOI=10.1126/science.146.3641.241
Cell Culture Collection Committee
Animal cell strains. The Cell Culture Collection Committee has assembled and certified 23 strains of animal cells.
Science 146:241-243(1964)

Gartler S.M.
Genetic markers as tracers in cell culture.
Natl. Cancer Inst. Monogr. 26:167-195(1967)

PubMed=5641128; DOI=10.1038/217750a0
Gartler S.M.
Apparent Hela cell contamination of human heteroploid cell lines.
Nature 217:750-751(1968)

PubMed=5668122; DOI=10.3181/00379727-128-33119
Peterson W.D. Jr., Stulberg C.S., Swanborg N.K., Robinson A.R.
Glucose-6-phosphate dehydrogenase isoenzymes in human cell cultures determined by sucrose-agar gel and cellulose acetate zymograms.
Proc. Soc. Exp. Biol. Med. 128:772-776(1968)

Stulberg C.S., Coriell L.L., Kniazeff A.J., Shannon J.E.
The animal cell culture collection.
In Vitro 5:1-16(1970)

PubMed=1246601; DOI=10.1126/science.1246601
Nelson-Rees W.A., Flandermeyer R.R.
HeLa cultures defined.
Science 191:96-98(1976)

PubMed=20143388; DOI=10.1002/ijc.25242
Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A., MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R., Freshney R.I.
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

Cell line collections ATCC; CCL-3 - Discontinued
Cell line databases/resources CLO; CLO_0002754
CLDB; cl1039
CLDB; cl1040
Biological sample resources BioSample; SAMN03151685
Encyclopedic resources Wikidata; Q54831004
Entry history
Entry creation04-Apr-2012
Last entry update21-Mar-2023
Version number23