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Cellosaurus COR-L47 (CVCL_2415)

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Cell line name COR-L47
Synonyms Cor L47; CORL47
Accession CVCL_2415
Resource Identification Initiative To cite this cell line use: COR-L47 (RRID:CVCL_2415)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Population: Caucasian.
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; miRNA profiling; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Derived from site: Metastatic; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Glu18Ter (c.52G>T); Zygosity=Homozygous (DepMap=ACH-000695).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg306Ter (c.916C>T); ClinVar=VCV000142144; Zygosity=Homozygous (DepMap=ACH-000695).
HLA typing Source: PubMed=25960936
Class I
HLA-AA*03:01,03:01
HLA-BB*08:01,37:04
HLA-CC*07:01,07:01

Source: PubMed=26589293
Class I
HLA-AA*03:01,03:01
HLA-BB*08:01,18:01
HLA-CC*07:01,07:01
Class II
HLA-DRDRB1*13:07,13:07
Genome ancestry Source: PubMed=30894373

Origin% genome
African1.67
Native American0.43
East Asian, North2.28
East Asian, South0
South Asian1.16
European, North59.47
European, South34.99
Disease Lung small cell carcinoma (NCIt: C4917)
Small cell lung cancer (ORDO: Orphanet_70573)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 67Y
Category Cancer cell line
STR profile Source(s): ECACC=92031915; PubMed=25877200

Markers:
AmelogeninX,Y
CSF1PO10,12
D3S135814
D5S81810,13
D7S8208,10
D8S117912,14
D13S31711
D16S53911,12
D18S5113,15
D21S1130,31.2
FGA24
Penta D9,12
Penta E11,12
TH016,8
TPOX8
vWA17

Run an STR similarity search on this cell line
Publications

PubMed=2998422; DOI=10.1038/bjc.1985.220; PMCID=PMC1977239
Hugo Baillie-Johnson, Peter Roy Twentyman, Norma E. Fox, G.A. Walls, Paul Workman, James V. Watson, Nicholas Johnson, Julie G. Reeve, Norman Montague Bleehen;
Establishment and characterisation of cell lines from patients with lung cancer (predominantly small cell carcinoma).
Br. J. Cancer 52:495-504(1985)

PubMed=3034934; DOI=10.1002/jcb.240330405
J.M. Ibson, Jonathan J. Waters, Peter Roy Twentyman, Norman Montague Bleehen, Pamela H. Rabbitts;
Oncogene amplification and chromosomal abnormalities in small cell lung cancer.
J. Cell. Biochem. 33:267-288(1987)

PubMed=12397641; DOI=10.1002/ijc.10704
Jamie N. Ashman, Jennie Brigham, Mike E. Cowen, Homer Bahia, John Greenman, Michael John Lind, Lynn Cawkwell;
Chromosomal alterations in small cell lung cancer revealed by multicolour fluorescence in situ hybridization.
Int. J. Cancer 102:230-236(2002)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Jordi Ginesta Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan, Adam A. Margolin, Sungjoon Kim, Christopher J. Wilson, Joseph Lehar, Gregory V. Kryukov, Dmitriy Sonkin, Anupama Reddy ...Show all 61 authors... , Manway Liu, Lauren Murray, Michael F. Berger, John E. Monahan, Paula Morais, Jodi Meltzer, Adam Korejwa, Judit Jane-Valbuena, Felipa A. Mapa, Joseph Thibault, Eva Bric-Furlong, Pichai Raman, Aaron Shipway, Ingo H. Engels, Jill Cheng, Guo-Ying K. Yu, Jian-Jun Yu, Peter Aspesi Jr., Melanie de Silva, Kalpana Jagtap, Michael D. Jones, Li Wang, Charles Hatton, Emanuele Palescandolo, Supriya Gupta, Scott Mahan, Carrie Sougnez, Robert C. Onofrio, Ted Liefeld, Laura E. MacConaill, Wendy Winckler, Michael Reich, Nan-Xin Li, Jill P. Mesirov, Stacey B. Gabriel, Gad Getz, Kristin Ardlie, Vivien Chan, Vic E. Myer, Barbara L. Weber, Jeff Porter, Markus Warmuth, Peter Finan, Jennifer L. Harris, Matthew Langer Meyerson, Todd Robert Golub, Michael P. Morrissey, William Raj Sellers, Robert Schlegel, Levi Alexander Garraway; Show fewer authors
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=25960936; DOI=10.4161/21624011.2014.954893; PMCID=PMC4355981
Sebastian Boegel, Martin Lower, Thomas Bukur, Ugur Sahin, John C. Castle;
A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.
OncoImmunology 3:e954893.1-e954893.12(2014)

PubMed=25485619; DOI=10.1038/nbt.3080
Christiaan Klijn, Steffen Durinck, Eric W. Stawiski, Peter M. Haverty, Zhao-Shi Jiang, Han-Bin Liu, Jeremiah Degenhardt, Oleg Mayba, Florian Gnad, Jin-Feng Liu, Gregoire Pau ...Show all 30 authors... , Jens Reeder, Yi Cao, Kiran Mukhyala, Suresh K. Selvaraj, Ma-Mie Yu, Gregory J. Zynda, Matthew J. Brauer, Thomas D. Wu, Robert Clifford Gentleman, Gerard Manning, Robert L. Yauch, Richard Bourgon, David Stokoe, Zora Modrusan, Richard M. Neve, Frederic J. de Sauvage, Jeffrey Settleman, Somasekar Seshagiri, Ze-Min Zhang; Show fewer authors
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Jelle Scholtalbers, Sebastian Boegel, Thomas Bukur, Marius Byl, Sebastian Goerges, Patrick Sorn, Martin Loewer, Ugur Sahin, John C. Castle;
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=27247353; DOI=10.1093/jnci/djw122; PMCID=PMC6279282
Eric C. Polley, Mark W. Kunkel, David Evans, Thomas E. Silvers, Rene M. Delosh, Julie Laudeman, Chad Ogle, Russell Reinhart, Michael Selby, John Connelly, Erik Harris ...Show all 18 authors... , Nicole Fer, Dmitriy Sonkin, Gurmeet Kaur, Anne Monks, Shakun Malik, Joel Morris, Beverly A. Teicher; Show fewer authors
Small cell lung cancer screen of oncology drugs, investigational agents, and gene and microRNA expression.
J. Natl. Cancer Inst. 108:djw122.1-djw122.11(2016)

PubMed=28766886; DOI=10.1002/cam4.1131; PMCID=PMC5548882
Beverly A. Teicher, Thomas E. Silvers, Michael Selby, Rene M. Delosh, Julie Laudeman, Chad Ogle, Russell Reinhart, Ralph E. Parchment, Julia Krushkal, Dmitriy Sonkin, Lawrence Rubinstein ...Show all 13 authors... , Joel Morris, David Evans; Show fewer authors
Small cell lung carcinoma cell line screen of etoposide/carboplatin plus a third agent.
Cancer Med. 6:1952-1964(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31978347; DOI=10.1016/j.cell.2019.12.023; PMCID=PMC7339254
David Paul Nusinow, John Szpyt, Mahmoud Ghandi, Christopher M. Rose, E. Robert McDonald 3rd, Marian Kalocsay, Judit Jane-Valbuena, Ellen T. Gelfand, Devin K. Schweppe, Mark P. Jedrychowski, Javad Golji ...Show all 20 authors... , Dale A. Porter, Tomas Rejtar, Y. Karen Wang, Gregory V. Kryukov, Frank Stegmeier, Brian K. Erickson, Levi Alexander Garraway, William Raj Sellers, Steven P. Gygi; Show fewer authors
Quantitative proteomics of the Cancer Cell Line Encyclopedia.
Cell 180:387-402.e16(2020)

PubMed=32586373; DOI=10.1186/s13148-020-00876-8; PMCID=PMC7318526
Julia Krushkal, Thomas E. Silvers, William C. Reinhold, Dmitriy Sonkin, Suleyman Vural, John Connelly, Sudhir Varma, Paul S. Meltzer, Mark W. Kunkel, Annamaria Rapisarda, David Evans ...Show all 13 authors... , Yves Pommier, Beverly A. Teicher; Show fewer authors
Epigenome-wide DNA methylation analysis of small cell lung cancer cell lines suggests potential chemotherapy targets.
Clin. Epigenetics 12:93.1-93.28(2020)

Cross-references
Cell line collections (Providers) ECACC; 92031915
Cell line databases/resources CLO; CLO_0002592
CLDB; cl882
cancercelllines; CVCL_2415
Cell_Model_Passport; SIDM01482
DepMap; ACH-000695
SKY/M-FISH/CGH; 1627
Biological sample resources BioSample; SAMN03473037
BioSample; SAMN10987980
CRISP screens repositories BioGRID_ORCS_Cell_line; 602
Chemistry resources ChEMBL-Cells; CHEMBL4523537
ChEMBL-Targets; CHEMBL4523568
PharmacoDB; CORL47_249_2019
PubChem_Cell_line; CVCL_2415
Encyclopedic resources Wikidata; Q54814290
Experimental variables resources EFO; EFO_0006556
Gene expression databases ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-2770
GEO; GSM886959
GEO; GSM888028
GEO; GSM1887954
GEO; GSM1888031
Polymorphism and mutation databases Cosmic; 753544
IARC_TP53; 28263
LiGeA; CCLE_621
Progenetix; CVCL_2415
Sequence databases EGA; EGAS00001000610
EGA; EGAS00001002554
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number36