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Cellosaurus COR-L47 (CVCL_2415)

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Cell line name COR-L47
Synonyms Cor L47; CORL47
Accession CVCL_2415
Resource Identification Initiative To cite this cell line use: COR-L47 (RRID:CVCL_2415)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Population: Caucasian.
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; miRNA profiling; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Derived from site: Metastatic; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Glu18Ter (c.52G>T); Zygosity=Homozygous (DepMap=ACH-000695).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg306Ter (c.916C>T); ClinVar=VCV000142144; Zygosity=Homozygous (DepMap=ACH-000695).
HLA typing Source: PubMed=25960936
Class I
HLA-AA*03:01,03:01
HLA-BB*08:01,37:04
HLA-CC*07:01,07:01

Source: PubMed=26589293
Class I
HLA-AA*03:01,03:01
HLA-BB*08:01,18:01
HLA-CC*07:01,07:01
Class II
HLA-DRDRB1*13:07,13:07
Genome ancestry Source: PubMed=30894373

Origin% genome
African1.67
Native American0.43
East Asian, North2.28
East Asian, South0
South Asian1.16
European, North59.47
European, South34.99
Disease Lung small cell carcinoma (NCIt: C4917)
Small cell lung cancer (ORDO: Orphanet_70573)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 67Y
Category Cancer cell line
STR profile Source(s): ECACC=92031915; PubMed=25877200

Markers:
AmelogeninX,Y
CSF1PO10,12
D3S135814
D5S81810,13
D7S8208,10
D8S117912,14
D13S31711
D16S53911,12
D18S5113,15
D21S1130,31.2
FGA24
Penta D9,12
Penta E11,12
TH016,8
TPOX8
vWA17

Run an STR similarity search on this cell line
Publications

PubMed=2998422; DOI=10.1038/bjc.1985.220; PMCID=PMC1977239
Baillie-Johnson H., Twentyman P.R., Fox N.E., Walls G.A., Workman P., Watson J.V., Johnson N., Reeve J.G., Bleehen N.M.
Establishment and characterisation of cell lines from patients with lung cancer (predominantly small cell carcinoma).
Br. J. Cancer 52:495-504(1985)

PubMed=3034934; DOI=10.1002/jcb.240330405
Ibson J.M., Waters J.J., Twentyman P.R., Bleehen N.M., Rabbitts P.H.
Oncogene amplification and chromosomal abnormalities in small cell lung cancer.
J. Cell. Biochem. 33:267-288(1987)

PubMed=12397641; DOI=10.1002/ijc.10704
Ashman J.N., Brigham J., Cowen M.E., Bahia H., Greenman J., Lind M.J., Cawkwell L.
Chromosomal alterations in small cell lung cancer revealed by multicolour fluorescence in situ hybridization.
Int. J. Cancer 102:230-236(2002)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=25960936; DOI=10.4161/21624011.2014.954893; PMCID=PMC4355981
Boegel S., Lower M., Bukur T., Sahin U., Castle J.C.
A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.
OncoImmunology 3:e954893.1-e954893.12(2014)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S., Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.-M.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=25877200; DOI=10.1038/nature14397
Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M., Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S., Neve R.M.
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P., Loewer M., Sahin U., Castle J.C.
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=27247353; DOI=10.1093/jnci/djw122; PMCID=PMC6279282
Polley E.C., Kunkel M.W., Evans D., Silvers T.E., Delosh R.M., Laudeman J., Ogle C., Reinhart R., Selby M., Connelly J., Harris E., Fer N., Sonkin D., Kaur G., Monks A., Malik S., Morris J., Teicher B.A.
Small cell lung cancer screen of oncology drugs, investigational agents, and gene and microRNA expression.
J. Natl. Cancer Inst. 108:djw122.1-djw122.11(2016)

PubMed=28766886; DOI=10.1002/cam4.1131; PMCID=PMC5548882
Teicher B.A., Silvers T.E., Selby M., Delosh R.M., Laudeman J., Ogle C., Reinhart R., Parchment R.E., Krushkal J., Sonkin D., Rubinstein L., Morris J., Evans D.
Small cell lung carcinoma cell line screen of etoposide/carboplatin plus a third agent.
Cancer Med. 6:1952-1964(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. 3rd, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31978347; DOI=10.1016/j.cell.2019.12.023; PMCID=PMC7339254
Nusinow D.P., Szpyt J., Ghandi M., Rose C.M., McDonald E.R. 3rd, Kalocsay M., Jane-Valbuena J., Gelfand E.T., Schweppe D.K., Jedrychowski M.P., Golji J., Porter D.A., Rejtar T., Wang Y.K., Kryukov G.V., Stegmeier F., Erickson B.K., Garraway L.A., Sellers W.R., Gygi S.P.
Quantitative proteomics of the Cancer Cell Line Encyclopedia.
Cell 180:387-402.e16(2020)

PubMed=32586373; DOI=10.1186/s13148-020-00876-8; PMCID=PMC7318526
Krushkal J., Silvers T.E., Reinhold W.C., Sonkin D., Vural S., Connelly J., Varma S., Meltzer P.S., Kunkel M.W., Rapisarda A., Evans D., Pommier Y., Teicher B.A.
Epigenome-wide DNA methylation analysis of small cell lung cancer cell lines suggests potential chemotherapy targets.
Clin. Epigenetics 12:93.1-93.28(2020)

Cross-references
Cell line collections (Providers) ECACC; 92031915
Cell line databases/resources CLO; CLO_0002592
CLDB; cl882
cancercelllines; CVCL_2415
Cell_Model_Passport; SIDM01482
DepMap; ACH-000695
SKY/M-FISH/CGH; 1627
Biological sample resources BioSample; SAMN03473037
BioSample; SAMN10987980
CRISP screens repositories BioGRID_ORCS_Cell_line; 602
Chemistry resources ChEMBL-Cells; CHEMBL4523537
ChEMBL-Targets; CHEMBL4523568
PharmacoDB; CORL47_249_2019
PubChem_Cell_line; CVCL_2415
Encyclopedic resources Wikidata; Q54814290
Experimental variables resources EFO; EFO_0006556
Gene expression databases ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-2770
GEO; GSM886959
GEO; GSM888028
GEO; GSM1887954
GEO; GSM1888031
Polymorphism and mutation databases Cosmic; 753544
IARC_TP53; 28263
LiGeA; CCLE_621
Progenetix; CVCL_2415
Sequence databases EGA; EGAS00001000610
EGA; EGAS00001002554
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number36