Cellosaurus cell line COR-L321 (CVCL

Cellosaurus COR-L321 (CVCL_2414)

[Text version]

Cell line name

COR-L321

Synonyms

CORL321

Accession

CVCL_2414

Resource Identification Initiative

To cite this cell line use: COR-L321 (RRID:CVCL_2414)

Comments

Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Caucasian.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.

Sequence variations

Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu171Ter (c.511G>T); ClinVar=VCV000634771; Zygosity=Heterozygous (DepMap=ACH-001490).
Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (DepMap=ACH-001490).

Genome ancestry

Source: PubMed=30894373

Origin	% genome
African	0
Native American	0
East Asian, North	0.7
East Asian, South	0
South Asian	0
European, North	67.03
European, South	32.26

Disease

Lung carcinoma (NCIt: C4878)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Sex of cell

Female

Age at sampling

58Y

Category

Cancer cell line

STR profile

Source(s): Cosmic-CLP=1322213; DepMap=ACH-001490

Markers:

Amelogenin	X
CSF1PO	12
D3S1358	16
D5S818	12
D7S820	10,11
D8S1179	10,13
D13S317	12,13
D16S539	11,12
D18S51	14,15
D21S11	30
FGA	22
Penta D	12
Penta E	7
TH01	7,9.3
TPOX	8,9
vWA	14,17

Publications

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references

Cell line collections (Providers)

ECACC; 96020756

Cell line databases/resources

cancercelllines; CVCL_2414
Cell_Model_Passport; SIDM00507
Cosmic-CLP; 1322213
DepMap; ACH-001490

Chemistry resources

GDSC; 1322213
PharmacoDB; CORL321_248_2019

Encyclopedic resources

Wikidata; Q54814287

Gene expression databases

ArrayExpress; E-MTAB-3610
GEO; GSM1669702

Proteomic databases

PRIDE; PXD030304

Sequence databases

EGA; EGAS00001000978

Entry history

Entry creation

04-Apr-2012

Last entry update

10-Apr-2025

Version number