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Cellosaurus BICR 78 (CVCL_2315)

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Cell line name BICR 78
Synonyms BICR-78; BICR78; Beatson Institute for Cancer Research 78
Accession CVCL_2315
Resource Identification Initiative To cite this cell line use: BICR 78 (RRID:CVCL_2315)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Caucasian.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; CRISPR screening.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Oral cavity, alveolar ridge; UBERON=UBERON_0004103.
Sequence variations
  • Mutation; HGNC; HGNC:16051; PARD3; Unexplicit; Ex3-7del; Zygosity=Homozygous (PubMed=20215515).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gln38Ter (c.112C>T); Zygosity=Heterozygous (Cosmic-CLP=1240122; DepMap=ACH-001332).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Cys176Phe (c.527G>T); ClinVar=VCV000376569; Zygosity=Heterozygous (PubMed=9150362; Cosmic-CLP=1240122; DepMap=ACH-001332).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro177Leu (c.530C>T); ClinVar=VCV000406583; Zygosity=Heterozygous (Cosmic-CLP=1240122; DepMap=ACH-001332).
HLA typing Source: PubMed=26589293
Class I
HLA-AA*02:01,29:02
HLA-BB*44:03,44:03
HLA-CC*05:01,16:01
Genome ancestry Source: PubMed=30894373

Origin% genome
African3.26
Native American1.14
East Asian, North2.29
East Asian, South0
South Asian0.91
European, North63.51
European, South28.89
Disease Alveolar ridge squamous cell carcinoma (NCIt: C170774)
Squamous cell carcinoma of the oral cavity (ORDO: Orphanet_502363)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=1240122; DepMap=ACH-001332; PubMed=25877200

Markers:
AmelogeninX
CSF1PO12
D3S135818
D5S81811
D7S82010,11
D8S117914
D13S31712
D16S53911,12
D18S5113,19
D21S1133.2
FGA19
Penta D10
Penta E11,13
TH016,9.3
TPOX9,10
vWA15,16

Run an STR similarity search on this cell line
Publications

PubMed=7646764; DOI=10.1002/mc.2940130408
Kirsten Gilian Edington, Oonagh P. Loughran, Isabella J. Berry, Eric Kenneth Parkinson;
Cellular immortality: a late event in the progression of human squamous cell carcinoma of the head and neck associated with p53 alteration and a high frequency of allele loss.
Mol. Carcinog. 13:254-265(1995)

PubMed=9150362; DOI=10.1038/sj.onc.1201028
Oonagh P. Loughran, Louise J. Clark, Jacquelyn Bond, Angela Baker, Isabella J. Berry, Kirsten Gilian Edington, I.-S. Ly, R. Simmons, Robin Haw, Donald M. Black, Robert F. Newbold, Eric Kenneth Parkinson;
Evidence for the inactivation of multiple replicative lifespan genes in immortal human squamous cell carcinoma keratinocytes.
Oncogene 14:1955-1964(1997)

PubMed=10523844; DOI=10.1038/sj.onc.1202957
Mahima Agochiya, Valerie G. Brunton, Dewi W. Owens, Eric Kenneth Parkinson, Christos Paraskeva, W. Nicol Keith, Margaret Catherine Frame;
Increased dosage and amplification of the focal adhesion kinase gene in human cancer cells.
Oncogene 18:5646-5653(1999)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=25485619; DOI=10.1038/nbt.3080
Christiaan Klijn, Steffen Durinck, Eric W. Stawiski, Peter M. Haverty, Zhao-Shi Jiang, Han-Bin Liu, Jeremiah Degenhardt, Oleg Mayba, Florian Gnad, Jin-Feng Liu, Gregoire Pau ...Show all 30 authors... , Jens Reeder, Yi Cao, Kiran Mukhyala, Suresh K. Selvaraj, Ma-Mie Yu, Gregory J. Zynda, Matthew J. Brauer, Thomas D. Wu, Robert Clifford Gentleman, Gerard Manning, Robert L. Yauch, Richard Bourgon, David Stokoe, Zora Modrusan, Richard M. Neve, Frederic J. de Sauvage, Jeffrey Settleman, Somasekar Seshagiri, Ze-Min Zhang; Show fewer authors
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Jelle Scholtalbers, Sebastian Boegel, Thomas Bukur, Marius Byl, Sebastian Goerges, Patrick Sorn, Martin Loewer, Ugur Sahin, John C. Castle;
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=30971826; DOI=10.1038/s41586-019-1103-9
Fiona M. Behan, Francesco Iorio, Gabriele Picco, Emanuel Goncalves, Charlotte M. Beaver, Giorgia Migliardi, Rita Santos, Yanhua Rao, Francesco Sassi, Marika Pinnelli, Rizwan Ansari ...Show all 25 authors... , Sarah Harper, David Adam Jackson, Rebecca McRae, Rachel Pooley, Piers Wilkinson, Dieudonne J. van der Meer, David Dow, Carolyn A. Buser-Doepner, Andrea Bertotti, Livio Trusolino, Euan Alexander Stronach, Julio Saez-Rodriguez, Kosuke Yusa, Mathew J. Garnett; Show fewer authors
Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.
Nature 568:511-516(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) CancerTools; 152849
ECACC; 04072111 - Discontinued
Ximbio; 152849
Cell line databases/resources CLO; CLO_0009944
cancercelllines; CVCL_2315
Cell_Model_Passport; SIDM00501
Cosmic-CLP; 1240122
DepMap; ACH-001332
LINCS_LDP; LCL-1205
Biological sample resources BioSample; SAMN03473146
CRISP screens repositories BioGRID_ORCS_Cell_line; 837
Chemistry resources GDSC; 1240122
PharmacoDB; BICR78_100_2019
Encyclopedic resources Wikidata; Q54796540
Experimental variables resources EFO; EFO_0006543
Gene expression databases ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-3610
GEO; GSM827457
GEO; GSM1669624
Polymorphism and mutation databases Cosmic; 848755
Cosmic; 1995346
Progenetix; CVCL_2315
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000610
EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number41